PMID- 35767152 OWN - NLM STAT- MEDLINE DCOM- 20221108 LR - 20221108 IS - 1720-8319 (Electronic) IS - 1594-0667 (Linking) VI - 34 IP - 10 DP - 2022 Oct TI - Association between human herpesvirus 6 (HHV-6) and cognitive function in the elderly population in Shenzhen, China. PG - 2407-2415 LID - 10.1007/s40520-022-02170-4 [doi] AB - AIM: Human herpesvirus 6 (HHV-6) is neurophilic, and its relationship with Alzheimer's disease (AD) remains controversial. This study aimed to examine the relationships between HHV-6 and cognitive abilities in elderly people aged 60 years or above from communities in Shenzhen. METHODS: We recruited participants from 10 community health service centers in Shenzhen. Participants were divided into case and control groups according to Mini-Mental State Examination (MMSE) scale standards and were included in this study with 1:1 matching based on sex and age (+/- 3 years). The HHV-6 gene was detected by real-time fluorescent quantitative PCR, and the HHV-6 copy number was quantified. RESULTS: A total of 580 participants (cases, n = 290; controls, n = 290), matched for gender and age was included in this study. A positive HHV-6 test was not associated with a significant difference in global cognitive performance (OR(adjusted) = 1.651, 95% CI = 0.671-4.062). After adjusting for gender, age, education, Pittsburgh Sleep Quality Index (PSQI) score, homocysteine (Hcy) and glycosylated hemoglobin (HbA1c), the results of multiple linear regression showed that there was a statistically negative correlation between HHV-6 copy number and orientation (beta(adjusted) = -0.974, p = 0.013), attention and calculation (beta(adjusted) = -1.840, p < 0.001), and language (beta(adjusted) = -2.267, p < 0.001). The restricted cubic spline (RCS) model results showed that there was a nonlinear dose-response relationship between HHV-6 log10-transformed copies and orientation (p(overall) = 0.003, p(nonliner) = 0.045), attention and calculation (p(overall) < 0.001, p(nonliner) < 0.001), and language (p(overall) < 0.001, p(nonliner) = 0.016). CONCLUSIONS: HHV-6 infection significantly associated with orientation, attention and calculation, and language in elderly individuals. CI - (c) 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Huang, Chao AU - Huang C AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. AD - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, People's Republic of China. FAU - Liu, Wei AU - Liu W AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Ren, Xiaohu AU - Ren X AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Lv, Yuan AU - Lv Y AD - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, People's Republic of China. FAU - Wang, Lu AU - Wang L AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Huang, Jia AU - Huang J AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. AD - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, People's Republic of China. FAU - Zhu, Feiqi AU - Zhu F AD - Cognitive Impairment Ward of Neurology Department, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, Guangdong, People's Republic of China. FAU - Wu, Desheng AU - Wu D AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Zhou, Li AU - Zhou L AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Huang, Xinfeng AU - Huang X AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. FAU - Liu, Jianjun AU - Liu J AD - Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, People's Republic of China. junii8@126.com. AD - Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, People's Republic of China. junii8@126.com. LA - eng GR - JCYJ20200109143431341/Shenzhen Basic Research Key Project/ GR - SZXK069/Shenzhen Key Medical Discipline Construction Fund/ GR - SZSM201611090/Sanming Project of Medicine in Shenzhen/ PT - Journal Article DEP - 20220629 PL - Germany TA - Aging Clin Exp Res JT - Aging clinical and experimental research JID - 101132995 SB - IM MH - Aged MH - Humans MH - *Herpesvirus 6, Human/genetics MH - *Roseolovirus Infections/complications MH - *Alzheimer Disease/complications MH - China MH - Cognition OTO - NOTNLM OT - Case-control study OT - Cognitive ability OT - Dose-response relationship OT - Human herpesvirus 6 OT - MMSE EDAT- 2022/06/30 06:00 MHDA- 2022/11/09 06:00 CRDT- 2022/06/29 11:19 PHST- 2022/05/18 00:00 [received] PHST- 2022/06/05 00:00 [accepted] PHST- 2022/06/30 06:00 [pubmed] PHST- 2022/11/09 06:00 [medline] PHST- 2022/06/29 11:19 [entrez] AID - 10.1007/s40520-022-02170-4 [pii] AID - 10.1007/s40520-022-02170-4 [doi] PST - ppublish SO - Aging Clin Exp Res. 2022 Oct;34(10):2407-2415. doi: 10.1007/s40520-022-02170-4. Epub 2022 Jun 29.