PMID- 35767272
OWN - NLM
STAT- MEDLINE
DCOM- 20230210
LR  - 20230513
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 76
IP  - 3
DP  - 2023 Feb 8
TI  - Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human 
      Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory 
      Syndrome.
PG  - 531-534
LID - 10.1093/cid/ciac514 [doi]
AB  - In the combination antiretroviral era, there are limited data regarding the 
      pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) 
      in people with human immunodeficiency virus (HIV). We immunologically 
      characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis 
      IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant 
      polyfunctional cytokine response to histoplasma antigen.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Manion, Maura
AU  - Manion M
AUID- ORCID: 0000-0003-0991-0011
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Boulougoura, Afroditi
AU  - Boulougoura A
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Naqvi, Nuha
AU  - Naqvi N
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Lage, Silvia Lucena
AU  - Lage SL
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Richards, Elizabeth
AU  - Richards E
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Grivas, Christopher
AU  - Grivas C
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Laidlaw, Elizabeth
AU  - Laidlaw E
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Kuriakose, Safia
AU  - Kuriakose S
AD  - Clinical Research Directorate, Frederick National Laboratory for Cancer Research, 
      Bethesda, Maryland, USA.
FAU - Ortega-Villa, Ana M
AU  - Ortega-Villa AM
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Tadros, Saber
AU  - Tadros S
AD  - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 
      USA.
FAU - Roby, Gregg
AU  - Roby G
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Rupert, Adam
AU  - Rupert A
AD  - Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer 
      Research, Frederick, Maryland, USA.
FAU - Galindo, France
AU  - Galindo F
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Anderson, Megan
AU  - Anderson M
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Pau, Alice
AU  - Pau A
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Deepe, George
AU  - Deepe G
AD  - Division of Infectious Diseases, University of Cincinnati College of Medicine, 
      Cincinnati, Ohio, USA.
FAU - Sheikh, Virginia
AU  - Sheikh V
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
FAU - Sereti, Irini
AU  - Sereti I
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
SB  - IM
MH  - Humans
MH  - CD4-Positive T-Lymphocytes
MH  - *Acquired Immunodeficiency Syndrome/complications
MH  - HIV
MH  - *Histoplasmosis
MH  - *Immune Reconstitution Inflammatory Syndrome
MH  - *HIV Infections/complications/drug therapy
PMC - PMC10169433
OTO - NOTNLM
OT  - HIV/AIDS
OT  - IRIS
OT  - histoplasmosis
COIS- Potential conflicts of interest. G. S. D. reports NIH funded grants NIH R01 AI 
      106269, NIH R01 AI 133797, and NIH R21 AI 160722. All other authors report no 
      potential conflicts. erest. All authors have submitted the ICMJE Form for 
      Disclosure of Potential Conflicts of Interest, Conflicts that the editors 
      consider relevant to the content of the manuscript have been disclosed.
EDAT- 2022/06/30 06:00
MHDA- 2023/02/11 06:00
PMCR- 2022/06/29
CRDT- 2022/06/29 11:33
PHST- 2022/02/16 00:00 [received]
PHST- 2022/06/30 06:00 [pubmed]
PHST- 2023/02/11 06:00 [medline]
PHST- 2022/06/29 11:33 [entrez]
PHST- 2022/06/29 00:00 [pmc-release]
AID - 6619620 [pii]
AID - ciac514 [pii]
AID - 10.1093/cid/ciac514 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2023 Feb 8;76(3):531-534. doi: 10.1093/cid/ciac514.