PMID- 35768559
OWN - NLM
STAT- MEDLINE
DCOM- 20220701
LR  - 20220906
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jun 29
TI  - Concurrent presence of high serum uric acid and inflammation is associated with 
      increased incidence of type 2 diabetes mellitus in Korean adult population.
PG  - 11000
LID - 10.1038/s41598-022-15176-9 [doi]
LID - 11000
AB  - Although serum uric acid level and systemic inflammation have been highlighted as 
      risk factors for type 2 diabetes mellitus (T2DM), little is known about these 
      associations in the Korean population. Thus, we examined the individual and 
      combined associations of serum uric acid and systemic inflammation (evaluated 
      using high-sensitivity C-reactive protein [hs-CRP] measurement) with the future 
      risk of T2DM. A total of 4152 Korean adults aged 45-76 years without T2DM, 
      cancer, or gout at baseline in 2007-2008 from the Korean Genome and Epidemiology 
      Study were followed up until 2016. Cox proportional hazard models were used to 
      estimate the multivariable-adjusted hazard ratios (HRs) and 95% confidence 
      intervals (CIs) of T2DM according to sex-specific tertiles of serum uric acid and 
      hs-CRP levels after adjustment for confounders. During the mean follow-up of 
      7.3 years, 548 participants developed T2DM. High serum uric acid and hs-CRP 
      levels were independently associated with an increased incidence of T2DM. The 
      multivariable-adjusted HRs (95% CIs) for the incidence of T2DM in the highest 
      tertiles of serum uric acid and hs-CRP were 1.54 (1.24-1.93) and 1.90 
      (1.48-2.43), respectively. High levels of serum uric acid and hs-CRP in 
      combination were associated with an increased incidence of T2DM (HR: 4.69; 95% 
      CI: 2.81-7.84) compared to low levels of serum uric acid and hs-CRP. These 
      findings suggest that the combination of high serum uric acid and hs-CRP levels 
      was significantly associated with an elevated incidence of T2DM; however, their 
      synergistic effects were not observed in middle-aged and elderly Korean adults.
CI  - (c) 2022. The Author(s).
FAU - Lee, Kyung Won
AU  - Lee KW
AD  - Department of Home Economics Education, Korea National University of Education, 
      Cheongju, 28173, Republic of Korea.
FAU - Shin, Dayeon
AU  - Shin D
AD  - Department of Food and Nutrition, Inha University, 100 Inha-ro, Michuhol-gu, 
      Incheon, 22212, Republic of Korea. dyshin@inha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220629
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - C-Reactive Protein/metabolism
MH  - *Diabetes Mellitus, Type 2/blood/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - *Uric Acid/blood
PMC - PMC9243007
COIS- The authors declare no competing interests.
EDAT- 2022/06/30 06:00
MHDA- 2022/07/02 06:00
PMCR- 2022/06/29
CRDT- 2022/06/29 23:26
PHST- 2021/12/14 00:00 [received]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/06/29 23:26 [entrez]
PHST- 2022/06/30 06:00 [pubmed]
PHST- 2022/07/02 06:00 [medline]
PHST- 2022/06/29 00:00 [pmc-release]
AID - 10.1038/s41598-022-15176-9 [pii]
AID - 15176 [pii]
AID - 10.1038/s41598-022-15176-9 [doi]
PST - epublish
SO  - Sci Rep. 2022 Jun 29;12(1):11000. doi: 10.1038/s41598-022-15176-9.