PMID- 35768671
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221103
IS  - 1612-9067 (Electronic)
IS  - 1612-9059 (Print)
IS  - 1612-9059 (Linking)
VI  - 19
IP  - 4
DP  - 2022 Oct
TI  - Clinical use of mean nocturnal baseline impedance and post-reflux swallow-induced 
      peristaltic wave index for the diagnosis of gastro-esophageal reflux disease.
PG  - 525-534
LID - 10.1007/s10388-022-00933-6 [doi]
AB  - The clinical diagnosis of gastro-esophageal reflux disease (GERD) is based on the 
      presence of typical esophageal troublesome symptoms. In clinical practice, 
      heartburn relief following a proton pump inhibitor (PPI) trial or endoscopy can 
      confirm a diagnosis of GERD. In cases of diagnostic uncertainty or before 
      anti-reflux interventions, combined impedance-pH monitoring (MII-pH) provides a 
      comprehensive assessment of both physical and chemical properties of the 
      refluxate, allowing to achieve a conclusive diagnosis of GERD. Recently, the Lyon 
      Consensus proposed the use of mean nocturnal baseline impedance (MNBI) and 
      post-reflux swallow-induced peristaltic wave index (PSPW-I) as novel MII-pH 
      metrics to support the diagnosis of GERD. The calculation of MNBI and PSPW-I 
      currently needs to be performed manually, but artificial intelligence systems for 
      the automated analysis of MII-pH tracings are being developed. Several studies 
      demonstrated the increased diagnostic yield MNBI and PSPW-I for the 
      categorization of patients with GERD at both on- and off-PPI MII-pH monitoring. 
      Accordingly, we performed a narrative review on the clinical use and diagnostic 
      yield of MNBI and PSPW-I when the diagnosis of GERD is uncertain. Based on 
      currently available evidence, we strongly support the evaluation of PSPW-I and 
      MNBI as part of the standard assessment of MII-pH tracings for the evaluation of 
      GERD, especially in patients with endoscopy-negative heartburn.
CI  - (c) 2022. The Author(s).
FAU - Visaggi, Pierfrancesco
AU  - Visaggi P
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Mariani, Lucia
AU  - Mariani L
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Svizzero, Federica Baiano
AU  - Svizzero FB
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Tarducci, Luca
AU  - Tarducci L
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Sostilio, Andrea
AU  - Sostilio A
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Frazzoni, Marzio
AU  - Frazzoni M
AD  - Digestive Pathophysiology Unit, Baggiovara Hospital, Modena, Italy.
FAU - Tolone, Salvatore
AU  - Tolone S
AD  - General and Bariatric Surgery Unit, Department of Surgery, University of Caserta 
      Luigi Vanvitelli, Caserta, Italy.
FAU - Penagini, Roberto
AU  - Penagini R
AD  - Department of Pathophysiology and Transplantation, University of Milan, Milan, 
      Italy.
AD  - Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale 
      Maggiore Policlinico, Milan, Italy.
FAU - Frazzoni, Leonardo
AU  - Frazzoni L
AD  - Gastroenterology Unit, Department of Medical and Surgical Sciences, Sant'Orsola 
      Hospital, University of Bologna, Bologna, Italy.
FAU - Ceccarelli, Linda
AU  - Ceccarelli L
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Savarino, Vincenzo
AU  - Savarino V
AD  - Gastroenterology Unit, Department of Internal Medicine "DiMI", University of 
      Genoa, Genoa, Italy.
FAU - Bellini, Massimo
AU  - Bellini M
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy.
FAU - Gyawali, Prakash C
AU  - Gyawali PC
AD  - Division of Gastroenterology, Washington University School of Medicine, St. 
      Louis, USA.
FAU - Savarino, Edoardo V
AU  - Savarino EV
AD  - Division of Gastroenterology, Department of Surgical, Oncological and 
      Gastroenterological Sciences, University of Padua, Padua, Italy.
FAU - de Bortoli, Nicola
AU  - de Bortoli N
AUID- ORCID: 0000-0003-1995-1060
AD  - Division of Gastroenterology, Department of Translational Research and New 
      Technologies in Medicine and Surgery, School of Medicine, University of Pisa, 
      Pisa, Italy. nicola.debortoli@unipi.it.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220629
PL  - Japan
TA  - Esophagus
JT  - Esophagus : official journal of the Japan Esophageal Society
JID - 101206627
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Artificial Intelligence
MH  - Electric Impedance
MH  - Endoscopy, Gastrointestinal
MH  - Esophageal pH Monitoring
MH  - *Gastroesophageal Reflux/diagnosis
MH  - *Heartburn/diagnosis
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Proton Pump Inhibitors
PMC - PMC9436885
OTO - NOTNLM
OT  - Diagnosis
OT  - GERD
OT  - MNBI
OT  - PSPW index
OT  - Reflux disease
COIS- Pierfrancesco Visaggi: None; Lucia Mariani: None; Federica Baiano Svizzero: None; 
      Luca Tarducci: None; Andrea Sostilio: None; Marzio Frazzoni: None; Salvatore 
      Tolone: None; Roberto Penagini: received Lecture Fee: Alfasigma, Reckitt 
      Benckiser, Sofar, Leonardo Frazzoni: None, Linda Ceccarelli: None; Vincenzo 
      Savarino: received lecture fees from Reckitt Benkiser, Takeda, Grunenthal, 
      Teofarma, Alfasigma; Massimo Bellini: None, Prakash C Gyawali: None, Edoardo V. 
      Savarino: received lecture fees from Abbvie, Alfasigma, Amgen, Aurora Pharma, 
      Bristol-Myers Squibb, EG Stada Group, Fresenius Kabi, Grifols, Janssen, 
      Johnson&Johnson, Innovamedica, Malesci, Medtronic, Merck & Co, Reckitt Benckiser, 
      Sandoz, Shire, SILA, Sofar, Takeda, Unifarco, Nicola de Bortoli: received lecture 
      fees from Malesci and Reckitt Benckiser.
EDAT- 2022/06/30 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/06/29
CRDT- 2022/06/29 23:33
PHST- 2022/03/23 00:00 [received]
PHST- 2022/06/07 00:00 [accepted]
PHST- 2022/06/30 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/06/29 23:33 [entrez]
PHST- 2022/06/29 00:00 [pmc-release]
AID - 10.1007/s10388-022-00933-6 [pii]
AID - 933 [pii]
AID - 10.1007/s10388-022-00933-6 [doi]
PST - ppublish
SO  - Esophagus. 2022 Oct;19(4):525-534. doi: 10.1007/s10388-022-00933-6. Epub 2022 Jun 
      29.