PMID- 35769408
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2671-8790 (Print)
IS  - 2671-8804 (Electronic)
IS  - 2671-8790 (Linking)
VI  - 33
IP  - 3
DP  - 2019 Sep 30
TI  - Clinical significance of donor-specific anti-HLA-DR51/52/53 antibodies for 
      antibody-mediated rejection in kidney transplant recipients.
PG  - 47-54
LID - 10.4285/jkstn.2019.33.3.47 [doi]
AB  - BACKGROUND: The presence of donor-specific antibodies (DSAs) to human leukocyte 
      antigen (HLA) increases the risk of antibody-mediated rejection (ABMR) after 
      kidney transplantation (KT). However, the clinical relevance of 
      anti-HLA-DR51/52/53 antibodies remains unclear because of their weak antigen 
      expression. This study evaluated the association between anti-HLA-DR51/52/53 DSAs 
      and ABMR. METHODS: We retrospectively reviewed the single-antigen-bead panel 
      reactive antibody (single PRA) results of 130 patients tested between August 1, 
      2009 and March 6, 2015, based on clinical necessity after allograft KT. Single 
      PRA analysis was performed using Luminex assay kits (Lifecodes LSA class I and 
      II). We reviewed the clinical course and biopsy results of patients with 
      anti-HLA-DR51/52/53 DSAs. RESULTS: Post-KT DSAs were identified in 89 of the 130 
      patients (68.5%), with 26 of 32 class I DSAs and 63 of 66 class II DSAs being 
      immunodominant DSAs. Thirteen patients had anti-HLA-DR51/52/53 DSAs. Three 
      patients with anti-HLA-DR51/52/53 immunodominant DSAs alone were diagnosed with 
      biopsy-proven ABMR. One patient who developed anti-HLA-DR DSA 13 days after KT 
      showed a rapid increase in anti-HLA-DR51 DSA and had biopsy-proven ABMR. 
      CONCLUSIONS: Although the expression of the HLA-DR51/52/53 antigen was weak, 
      anti-HLA-DR51/52/53 DSAs might be correlated with biopsy-proven ABMR. Therefore, 
      anti-HLA-DR51/52/53 DSAs must be evaluated as a cause of ABMR after 
      transplantation.
CI  - Copyright: (c) 2020 The Korean Society for Transplantation.
FAU - Park, Borae Geum
AU  - Park BG
AUID- ORCID: 0000-0001-9710-9253
AD  - Department of Laboratory Medicine, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Korea.
AD  - Department of Laboratory Medicine, Korea University Guro Hospital, Seoul, Korea.
FAU - Park, Younhee
AU  - Park Y
AUID- ORCID: 0000-0001-8458-1495
AD  - Department of Laboratory Medicine, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Korea.
FAU - Joo, Dong Jin
AU  - Joo DJ
AUID- ORCID: 0000-0001-8405-1531
AD  - Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Huh, Kyu Ha
AU  - Huh KH
AUID- ORCID: 0000-0003-1364-6989
AD  - Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Myoung Soo
AU  - Kim MS
AUID- ORCID: 0000-0002-8975-8381
AD  - Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Soon Il
AU  - Kim SI
AUID- ORCID: 0000-0002-0783-7538
AD  - Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Yu Seun
AU  - Kim YS
AUID- ORCID: 0000-0002-5105-1567
AD  - Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Hyon-Suk
AU  - Kim HS
AUID- ORCID: 0000-0001-5662-7740
AD  - Department of Laboratory Medicine, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Korean J Transplant
JT  - Korean journal of transplantation
JID - 101775609
PMC - PMC9188942
OTO - NOTNLM
OT  - Antibody mediated rejection
OT  - Donor specific antibody
OT  - Human leukocyte antigen
EDAT- 2019/09/30 00:00
MHDA- 2019/09/30 00:01
PMCR- 2019/09/30
CRDT- 2022/06/30 02:34
PHST- 2019/03/14 00:00 [received]
PHST- 2019/08/12 00:00 [revised]
PHST- 2019/08/13 00:00 [accepted]
PHST- 2022/06/30 02:34 [entrez]
PHST- 2019/09/30 00:00 [pubmed]
PHST- 2019/09/30 00:01 [medline]
PHST- 2019/09/30 00:00 [pmc-release]
AID - KJT-33-3-047 [pii]
AID - 10.4285/jkstn.2019.33.3.47 [doi]
PST - ppublish
SO  - Korean J Transplant. 2019 Sep 30;33(3):47-54. doi: 10.4285/jkstn.2019.33.3.47.