PMID- 35770226
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Plasma Homocysteine Level Is Independently Associated With Conventional 
      Atherogenic Lipid Profile and Remnant Cholesterol in Adults.
PG  - 898305
LID - 10.3389/fcvm.2022.898305 [doi]
LID - 898305
AB  - BACKGROUND: Homocysteine (Hcy) is an independent risk factor for cardiovascular 
      disease, while mechanisms are unclear. Despite inconsistent and limited, 
      epidemiological and experimental studies indicated that hyperhomocysteinemia 
      (HHcy) affected lipid metabolism. This study aims to investigate the association 
      of plasma Hcy with traditional lipid profiles and remnant cholesterol (RC) in 
      Chinese adults. METHODS: In total, 7,898 subjects aged 20-79 years who underwent 
      a physical examination at Beijing Chao-Yang Hospital in Beijing were included in 
      this study. Fasting plasma total cholesterol (TC), triglyceride (TG), 
      high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol 
      (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein (a) 
      [Lp(a)], Hcy, and other metabolic risk factors were measured by routine automated 
      laboratory methods. RC was calculated as TC minus HDL-C and LDL-C. The linear 
      regression model and logistic regression model were used to assess the 
      relationship between Hcy and lipids after adjusting potential confounders. 
      RESULTS: Of the subjects, the median level of plasma Hcy was 13.0 mumol/L and 
      32.3% had HHcy. Plasma Hcy was negatively associated with HDL-C, ApoA1, and Lp(a) 
      and positively associated with TG levels after adjusting age, sex, body mass 
      index, blood pressure, alanine transaminase, aspartate transaminase, creatinine, 
      uric acid, and glucose. HHcy significantly increased the risk of low HDL-C [odds 
      ratio (OR) 1.26; 95%CI (1.11-1.44); p < 0.001]. The net mediation effects of 
      ApoA1 on the relationship between Hcy and HDL-C before and after adjusting 
      confounders were 46.9 and 30.6%, respectively. More interestingly, the RC level 
      was significantly elevated in subjects with HHcy after adjusting other 
      influencing factors (p = 0.025). Hcy presented a positive correlation with RC 
      levels after adjusting the above confounding factors (beta = 0.073, p = 0.004), and 
      the correlation was still significant even after controlling other lipids, 
      including TG, LDL-C, HDL-C, ApoA1, ApoB, and Lp(a). CONCLUSION: Our study showed 
      that plasma Hcy was not only significantly associated with conventional 
      atherogenic lipids but also independently correlated with RC levels beyond other 
      lipids after controlling potential confounders. This finding proposes that 
      identifying Hcy-related dyslipidemia risk, both traditional lipids and RC 
      residual risk, is clinically relevant as we usher in a new era of targeting 
      Hcy-lowering therapies to fight against dyslipidemia or even cardiovascular 
      disease.
CI  - Copyright (c) 2022 Zhou, Liu, An, Wang and Wang.
FAU - Zhou, Liyuan
AU  - Zhou L
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Liu, Jia
AU  - Liu J
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, China.
FAU - An, Yu
AU  - An Y
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Medical Examination Center, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Guang
AU  - Wang G
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220613
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9234129
OTO - NOTNLM
OT  - Chinese adults
OT  - apolipoprotein A1
OT  - high-density lipoprotein cholesterol
OT  - homocysteine
OT  - remnant cholesterol
OT  - triglyceride
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/01 06:00
MHDA- 2022/07/01 06:01
PMCR- 2022/01/01
CRDT- 2022/06/30 02:53
PHST- 2022/03/17 00:00 [received]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/06/30 02:53 [entrez]
PHST- 2022/07/01 06:00 [pubmed]
PHST- 2022/07/01 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.898305 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Jun 13;9:898305. doi: 10.3389/fcvm.2022.898305. 
      eCollection 2022.