PMID- 35770783
OWN - NLM
STAT- MEDLINE
DCOM- 20220725
LR  - 20230802
IS  - 1521-1878 (Electronic)
IS  - 0265-9247 (Print)
IS  - 0265-9247 (Linking)
VI  - 44
IP  - 8
DP  - 2022 Aug
TI  - Bro1 family proteins harmonize cargo sorting with vesicle formation.
PG  - e2100276
LID - 10.1002/bies.202100276 [doi]
AB  - The Endosomal Sorting Complexes Required for Transport (ESCRTs) drive membrane 
      remodeling in a variety of cellular processes that include the formation of 
      endosomal intralumenal vesicles (ILVs) during multivesicular body (MVB) 
      biogenesis. During MVB sorting, ESCRTs recognize ubiquitin (Ub) attached to 
      membrane protein cargo and execute ILV formation by controlling the activities of 
      ESCRT-III polymers regulated by the AAA-ATPase Vps4. Exactly how these events are 
      coordinated to ensure proper cargo loading into ILVs remains unclear. Here we 
      discuss recent work documenting the ability of Bro1, an ESCRT-associated 
      Ub-binding protein, to coordinate ESCRT-III and Vps4-dependent ILV biogenesis 
      with upstream events such as cargo recognition.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Tseng, Chun-Che
AU  - Tseng CC
AUID- ORCID: 0000-0001-9637-4127
AD  - Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 
      Minnesota, USA.
AD  - Biochemistry and Molecular Biology Graduate Program, Mayo Clinic Graduate School 
      of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Piper, Robert C
AU  - Piper RC
AUID- ORCID: 0000-0001-9995-5699
AD  - Department of Molecular Physiology and Biophysics, Carver College of Medicine, 
      University of Iowa, Iowa City, Iowa, USA.
FAU - Katzmann, David J
AU  - Katzmann DJ
AUID- ORCID: 0000-0001-8622-343X
AD  - Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, 
      Minnesota, USA.
AD  - Biochemistry and Molecular Biology Graduate Program, Mayo Clinic Graduate School 
      of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
LA  - eng
GR  - R01 GM058202/GM/NIGMS NIH HHS/United States
GR  - R01 GM116826/GM/NIGMS NIH HHS/United States
GR  - R01 GM58202/NH/NIH HHS/United States
GR  - R01 GM116826/NH/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220630
PL  - United States
TA  - Bioessays
JT  - BioEssays : news and reviews in molecular, cellular and developmental biology
JID - 8510851
RN  - 0 (Endosomal Sorting Complexes Required for Transport)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Ubiquitin)
SB  - IM
MH  - Endosomal Sorting Complexes Required for Transport/chemistry
MH  - Endosomes/metabolism
MH  - *Multivesicular Bodies/metabolism
MH  - Protein Transport
MH  - *Saccharomyces cerevisiae Proteins/metabolism
MH  - Ubiquitin/metabolism
PMC - PMC9575758
MID - NIHMS1821654
EDAT- 2022/07/01 06:00
MHDA- 2022/07/26 06:00
PMCR- 2023/08/01
CRDT- 2022/06/30 06:22
PHST- 2022/05/31 00:00 [revised]
PHST- 2021/11/29 00:00 [received]
PHST- 2022/06/08 00:00 [accepted]
PHST- 2022/07/01 06:00 [pubmed]
PHST- 2022/07/26 06:00 [medline]
PHST- 2022/06/30 06:22 [entrez]
PHST- 2023/08/01 00:00 [pmc-release]
AID - 10.1002/bies.202100276 [doi]
PST - ppublish
SO  - Bioessays. 2022 Aug;44(8):e2100276. doi: 10.1002/bies.202100276. Epub 2022 Jun 
      30.