PMID- 35771293
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230314
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 43
IP  - 3
DP  - 2023 Apr
TI  - Oxygen-Glucose Deprivation Decreases the Motility and Length of Axonal 
      Mitochondria in Cultured Dorsal Root Ganglion Cells of Rats.
PG  - 1267-1280
LID - 10.1007/s10571-022-01247-y [doi]
AB  - Controlling axonal mitochondria is important for maintaining normal function of 
      the neural network. Oxygen-glucose deprivation (OGD), a model used for mimicking 
      ischemia, eventually induces neuronal cell death similar to axonal degeneration. 
      Axonal mitochondria are disrupted during OGD-induced neural degeneration; 
      however, the mechanism underlying mitochondrial dysfunction has not been 
      completely understood. We focused on the dynamics of mitochondria in axons 
      exposed to OGD; we observed that the number of motile mitochondria significantly 
      reduced in 1 h following OGD exposure. In our observation, the decreased length 
      of stationary mitochondria was affected by the following factors: first, the halt 
      of motile mitochondria; second, the fission of longer stationary mitochondria; 
      and third, a transformation from tubular to spherical shape in OGD-exposed axons. 
      Motile mitochondria reduction preceded stationary mitochondria fragmentation in 
      OGD exposure; these conditions induced the decrease of stationary mitochondria in 
      three different ways. Our results suggest that mitochondrial morphological 
      changes precede the axonal degeneration while ischemia-induced neurodegeneration.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Kikuchi, Shin
AU  - Kikuchi S
AUID- ORCID: 0000-0002-0401-195X
AD  - Department of Anatomy 1, Sapporo Medical University School of Medicine, West 17, 
      South 1, Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan. ksin@sapmed.ac.jp.
FAU - Kohno, Takayuki
AU  - Kohno T
AUID- ORCID: 0000-0002-1782-3578
AD  - Department of Cell Sciences, Research Institute for Frontier Medicine, Sapporo 
      Medical University School of Medicine, West 17, South 1, Chuo-ku, Sapporo, 
      Hokkaido, 060-8556, Japan.
FAU - Kojima, Takashi
AU  - Kojima T
AD  - Department of Cell Sciences, Research Institute for Frontier Medicine, Sapporo 
      Medical University School of Medicine, West 17, South 1, Chuo-ku, Sapporo, 
      Hokkaido, 060-8556, Japan.
FAU - Tatsumi, Haruyuki
AU  - Tatsumi H
AD  - Department of Anatomy 1, Sapporo Medical University School of Medicine, West 17, 
      South 1, Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
FAU - Ohsaki, Yuki
AU  - Ohsaki Y
AUID- ORCID: 0000-0002-8472-6962
AD  - Department of Anatomy 1, Sapporo Medical University School of Medicine, West 17, 
      South 1, Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
FAU - Ninomiya, Takafumi
AU  - Ninomiya T
AD  - Department of Anatomy 1, Sapporo Medical University School of Medicine, West 17, 
      South 1, Chuo-ku, Sapporo, Hokkaido, 060-8556, Japan.
LA  - eng
GR  - 15K01419/Japan Society for the Promotion of Science/
GR  - 19K05736/Japan Society for the Promotion of Science/
GR  - 19K07464/Japan Society for the Promotion of Science/
GR  - 21K06733/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20220630
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - S88TT14065 (Oxygen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
EIN - Cell Mol Neurobiol. 2022 Jul 14;:. PMID: 35834045
MH  - Rats
MH  - Animals
MH  - *Oxygen/metabolism
MH  - *Glucose/metabolism
MH  - Ganglia, Spinal/metabolism
MH  - Rats, Sprague-Dawley
MH  - Axons/metabolism
MH  - Cells, Cultured
MH  - Mitochondria/metabolism
OTO - NOTNLM
OT  - Axon
OT  - Fission
OT  - Mitochondria
OT  - Oxygen-glucose deprivation (OGD)
EDAT- 2022/07/01 06:00
MHDA- 2023/03/15 06:00
CRDT- 2022/06/30 11:15
PHST- 2022/04/08 00:00 [received]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/07/01 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2022/06/30 11:15 [entrez]
AID - 10.1007/s10571-022-01247-y [pii]
AID - 10.1007/s10571-022-01247-y [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2023 Apr;43(3):1267-1280. doi: 10.1007/s10571-022-01247-y. 
      Epub 2022 Jun 30.