PMID- 35773172
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220927
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 36
IP  - 8
DP  - 2022 Aug
TI  - The predictive value of Thromboelastography (TEG) parameters in vascular 
      complications in patients with type 2 diabetes mellitus.
PG  - 108236
LID - S1056-8727(22)00142-8 [pii]
LID - 10.1016/j.jdiacomp.2022.108236 [doi]
AB  - AIMS: The purpose of this research was to explore the association of TEG 
      parameters (Reaction time, R; Clot kinetics, K; Alpha angle, alpha-angle; Maximum 
      amplitude, MA) with vascular complications of type 2 diabetes mellitus (T2DM), 
      and assess whether TEG parameters could predict T2DM patients with vascular 
      complications. METHODS: A total of 68 healthy controls (HC), 57 T2DM patients 
      without vascular complications (NC), 18 T2DM patients with only microvascular 
      complications (MIC), 196 T2DM patients with only macrovascular complications 
      (MAC), and 94 T2DM patients with both microvascular and macrovascular 
      complications (MIC+MAC) were recruited in this study. Participants' clinical 
      information and TEG parameters were recorded. TEG parameters were analyzed by the 
      Jonckheere-Terpstra trend test, assuming the vascular complication was 
      progressing from HC --> NC --> MIC --> MIC+MAC or HC --> NC --> MAC --> MIC+MAC. Receiver 
      operating characteristic (ROC) was performed to explore the diagnostic accuracy 
      of TEG parameters in T2DM with vascular complications. RESULTS: Shorter TEGK, 
      higher TEG-alpha-angle, and higher TEG-MA were found in T2DM patients with both 
      microvascular and macrovascular complications (MIC+MAC) group compared with 
      healthy controls (HC) group and T2DM patients without vascular complications (NC) 
      group (P < 0.05). Trend analysis showed that TEG-R/K decreased, but 
      TEG-alpha-angle/MA increased gradually as the vascular complication progressed 
      (P < 0.001). With stratification of urine microalbumin/creatinine ratio (UACR), 
      diabetic nephropathy with macroalbuminuria (grade A3) behaves shorter TEGK, 
      higher TEG-alpha-angle/MA compared with normal to mildly increased albuminuria (grade 
      A1) and microalbuminuria (grade A2) (P < 0.05). ROC curves implied that TEGK, 
      TEG-alpha-angle, and TEG-MA have moderate diagnostic values in T2DM without vascular 
      complications (K-AUC: 0.780, alpha-angle-AUC: 0.773, and MA-AUC: 0.740) as well as 
      T2DM with both microvascular and macrovascular complications (K-AUC: 0.778, 
      alpha-angle-AUC: 0.757, and MA-AUC: 0.800). CONCLUSION: TEG parameters are associated 
      with the progression of vascular complications in T2DM, and it could be a 
      diagnostic indicator for T2DM without vascular complications or with advanced 
      vascular complications.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Hu, Bin
AU  - Hu B
AD  - Department of Clinical Laboratory, Ningbo Medical Treatment Center Lihuili 
      Hospital, Ningbo, Zhejiang, People's Republic of China.
FAU - Zhang, Long
AU  - Zhang L
AD  - Department of Endocrinology and Metabolism, Ningbo Medical Treatment Center 
      Lihuili Hospital, Ningbo, Zhejiang, People's Republic of China.
FAU - Zhao, Zhang-Sheng
AU  - Zhao ZS
AD  - Department of Blood Transfusion, Ningbo Medical Treatment Center Lihuili 
      Hospital, Ningbo, Zhejiang, People's Republic of China. Electronic address: 
      zszhaonb@163.com.
FAU - Qi, Yang-Cong
AU  - Qi YC
AD  - Department of Blood Transfusion, Ningbo Medical Treatment Center Lihuili 
      Hospital, Ningbo, Zhejiang, People's Republic of China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Blood Transfusion, Ningbo Medical Treatment Center Lihuili 
      Hospital, Ningbo, Zhejiang, People's Republic of China.
FAU - Ma, You-Li
AU  - Ma YL
AD  - Department of Blood Transfusion, Ningbo Medical Treatment Center Lihuili 
      Hospital, Ningbo, Zhejiang, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220624
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - *Cardiovascular Diseases
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Humans
MH  - ROC Curve
MH  - Thrombelastography
OTO - NOTNLM
OT  - Coagulation
OT  - Thromboelastography
OT  - Type 2 diabetes
OT  - Vascular complication
EDAT- 2022/07/01 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/06/30 22:08
PHST- 2022/01/18 00:00 [received]
PHST- 2022/05/14 00:00 [revised]
PHST- 2022/06/19 00:00 [accepted]
PHST- 2022/07/01 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/06/30 22:08 [entrez]
AID - S1056-8727(22)00142-8 [pii]
AID - 10.1016/j.jdiacomp.2022.108236 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2022 Aug;36(8):108236. doi: 
      10.1016/j.jdiacomp.2022.108236. Epub 2022 Jun 24.