PMID- 35774110
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230725
IS  - 2516-1571 (Electronic)
IS  - 2096-5303 (Print)
IS  - 2516-1571 (Linking)
VI  - 5
IP  - 2
DP  - 2022 Jun
TI  - Health consequences of early-onset compared with late-onset type 2 diabetes 
      mellitus.
PG  - pbac015
LID - 10.1093/pcmedi/pbac015 [doi]
LID - pbac015
AB  - BACKGROUND: Although cumulating evidence has suggested that early-onset type 2 
      diabetes mellitus (T2DM) conferred on patients a broader tendency for 
      complications beyond vascular ones, a comprehensive analysis of patterns of 
      complications across all relevant systems is currently lacking. METHOD: We 
      prospectively studied 1 777 early-onset (age at diagnosis </= 45 years) and 35 889 
      late-onset (>45 years) T2DM patients with matched unexposed individuals from the 
      UK Biobank. Diabetes-specific and -related complications were examined using 
      phenome-wide association analysis, with patterns identified by comorbidity 
      network analysis. We also evaluated the effect of lifestyle modifications and 
      glycemic control on complication development. RESULTS: The median follow-up times 
      for early-onset and late-onset T2DM patients were 17.83 and 9.39 years, 
      respectively. Compared to late-onset T2DM patients, patients with early-onset 
      T2DM faced a significantly higher relative risk of developing subsequent 
      complications that primarily affected sense organs [hazard ratio (HR) 3.46 vs. 
      1.72], the endocrine/metabolic system (HR 3.08 vs. 2.01), and the neurological 
      system (HR 2.70 vs. 1.81). Despite large similarities in comorbidity patterns, a 
      more complex and well-connected network was observed for early-onset T2DM. 
      Furthermore, while patients with early-onset T2DM got fewer benefits (12.67% 
      reduction in pooled HR for all studied complications) through fair glycemic 
      control (median HbA(1c) </= 53 mmol/mol) compared to late-onset T2DM patients 
      (18.01% reduction), they seemed to benefit more from favorable lifestyles, 
      including weight control, healthy diet, and adequate physical activity. 
      CONCLUSIONS: Our analyses reveal that early-onset T2DM is an aggressive disease 
      resulting in more complex complication networks than late-onset T2DM. Aggressive 
      glucose-lowering intervention, complemented by lifestyle modifications, are 
      feasible strategies for controlling early-onset T2DM-related complications.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the West 
      China School of Medicine & West China Hospital of Sichuan University.
FAU - Hou, Can
AU  - Hou C
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Yang, Huazhen
AU  - Yang H
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Qu, Yuanyuan
AU  - Qu Y
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Chen, Wenwen
AU  - Chen W
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Zeng, Yu
AU  - Zeng Y
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Hu, Yao
AU  - Hu Y
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Narayan, K M Venkat
AU  - Narayan KMV
AD  - Emory Global Diabetes Research Center (EGDRC), Rollins School of Public Health, 
      Emory University, Atlanta, GA 30322, USA.
FAU - Song, Huan
AU  - Song H
AD  - West China Biomedical Big Data Center, West China Hospital, Sichuan University, 
      Chengdu 610041, China.
FAU - Li, Dong
AU  - Li D
AD  - Emory Global Diabetes Research Center (EGDRC), Rollins School of Public Health, 
      Emory University, Atlanta, GA 30322, USA.
LA  - eng
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
GR  - P30 DK111024/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20220606
PL  - England
TA  - Precis Clin Med
JT  - Precision clinical medicine
JID - 101739592
PMC - PMC9239845
OTO - NOTNLM
OT  - comorbidity network analysis
OT  - early-onset type 2 diabetes mellitus
OT  - late-onset type 2 diabetes mellitus
OT  - phenome-wide association analysis
EDAT- 2022/07/02 06:00
MHDA- 2022/07/02 06:01
PMCR- 2022/06/06
CRDT- 2022/07/01 02:27
PHST- 2022/01/28 00:00 [received]
PHST- 2022/05/03 00:00 [revised]
PHST- 2022/06/01 00:00 [accepted]
PHST- 2022/07/01 02:27 [entrez]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/07/02 06:01 [medline]
PHST- 2022/06/06 00:00 [pmc-release]
AID - pbac015 [pii]
AID - 10.1093/pcmedi/pbac015 [doi]
PST - epublish
SO  - Precis Clin Med. 2022 Jun 6;5(2):pbac015. doi: 10.1093/pcmedi/pbac015. 
      eCollection 2022 Jun.