PMID- 35774637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2590-1575 (Electronic)
IS  - 2590-1575 (Linking)
VI  - 14
DP  - 2022 Jun 30
TI  - Metabolomics and biochemical insights on the regulation of aging-related diabetes 
      by a low-molecular-weight polysaccharide from green microalga Chlorella 
      pyrenoidosa.
PG  - 100316
LID - 10.1016/j.fochx.2022.100316 [doi]
LID - 100316
AB  - Globally, aging and diabetes are considered prevalent threats to human health. 
      Chlorella pyrenoidosa polysaccharide (CPP) is a natural active ingredient with 
      multiple health benefits including antioxidant and hypolipidemic activities. In 
      this study, the aging-related diabetic (AD) mice model was established to 
      investigate the underlying hypoglycemic and antioxidant mechanisms of CPP. It 
      improved superoxide dismutase, catalase (CAT), glutathione peroxidase (GSH-px), 
      and malondialdehyde activities in liver and insulin secretion. CAT and GSH-px 
      activity in the brain increased after CPP administration. In addition, through 
      histopathological examinations, it was evident that injuries in the liver, brain, 
      jejunum, and pancreas were restored by CPP. This restoration was likely mediated 
      via the activation of glucagon-like peptide-1 receptor/FOXO-1 (forkhead box O1) 
      pathway concurrent with the inhibition of interleukin-6 receptor/FOXO-1 pathway. 
      Furthermore, metabolomics and correlation analysis revealed that CPP possibly 
      relived AD through changes in insulin levels and declined oxidative stress as 
      regulated by phenylpyruvic acid. These findings suggested that CPP exerted 
      antioxidant and hypoglycemic roles in an AD mice model, thereby providing a sound 
      scientific foundation for further development and utilization of CPP.
CI  - (c) 2022 The Author(s).
FAU - Qiu, Yinghui
AU  - Qiu Y
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Gao, Xiaoxiang
AU  - Gao X
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Chen, Ruoxin
AU  - Chen R
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Lu, Suyue
AU  - Lu S
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Wan, Xuzhi
AU  - Wan X
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Farag, Mohamed A
AU  - Farag MA
AD  - Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, 
      Egypt.
FAU - Zhao, Chao
AU  - Zhao C
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
AD  - Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and 
      Nutrition, Ministry of Education, Fuzhou 350002, China.
AD  - Key Laboratory of Marine Biotechnology of Fujian Province, Institute of 
      Oceanology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
LA  - eng
PT  - Journal Article
DEP - 20220423
PL  - Netherlands
TA  - Food Chem X
JT  - Food chemistry: X
JID - 101751436
PMC - PMC9237631
OTO - NOTNLM
OT  - Antioxidant
OT  - Chlorella pyrenoidosa polysaccharide
OT  - Metabolomics
OT  - Phenylpyruvic acid
OT  - Type 2 diabetes
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/07/02 06:00
MHDA- 2022/07/02 06:01
PMCR- 2022/04/23
CRDT- 2022/07/01 02:40
PHST- 2022/01/09 00:00 [received]
PHST- 2022/04/14 00:00 [revised]
PHST- 2022/04/20 00:00 [accepted]
PHST- 2022/07/01 02:40 [entrez]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/07/02 06:01 [medline]
PHST- 2022/04/23 00:00 [pmc-release]
AID - S2590-1575(22)00114-6 [pii]
AID - 100316 [pii]
AID - 10.1016/j.fochx.2022.100316 [doi]
PST - epublish
SO  - Food Chem X. 2022 Apr 23;14:100316. doi: 10.1016/j.fochx.2022.100316. eCollection 
      2022 Jun 30.