PMID- 35777342
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220719
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 241
DP  - 2022 Aug
TI  - Associations between prenatal exposure to perfluoroalkyl substances and 
      neurobehavioral development in early childhood: A prospective cohort study.
PG  - 113818
LID - S0147-6513(22)00658-3 [pii]
LID - 10.1016/j.ecoenv.2022.113818 [doi]
AB  - Findings from epidemiological studies on the associations between prenatal 
      perfluoroalkyl substances (PFASs) exposure and children's neurodevelopment were 
      inconclusive, and most studies did not account for the co-exposure to multiple 
      PFASs with strong inter-correlations. The present study aimed to assess the 
      effects of prenatal multiple PFAS exposure on children's neurobehavioral 
      development based on 614 mother-infant pairs in the Shanghai-Minhang Birth Cohort 
      Study. Eight PFAS concentrations were measured in maternal plasma at 12-16 weeks 
      of gestation. Children's neurobehavioral development at 2 and 4 years of age was 
      assessed by the Child Behavior Checklist for Ages 1.5-5. In Bayesian kernel 
      machine regression (BKMR) analyses that could address the inter-correlations 
      between multiple PFASs, PFAS mixture appeared to be associated with fewer Somatic 
      Complaints and more Externalizing Problems in boys, but more Somatic Complaints 
      and Sleep Problems in girls. There were suggestive associations of PFNA and PFOS 
      with decreased risk of Somatic Complaints and of PFUdA and PFTrDA with increased 
      risk of Externalizing Problems in boys; trends of increased risk in girls were 
      observed between PFUdA and Somatic Complaints and between PFTrDA and Sleep 
      Problems. Overall, we found no clear evidence that prenatal exposure to PFASs had 
      negative effects on neurobehavioral development in children. However, the modest 
      associations still suggested the potential developmental neurotoxicity of 
      prenatal PFAS exposure.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Xie, Zhenzhen
AU  - Xie Z
AD  - NHC Key Lab. of Reproduction Regulation (Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies), School of Public Health, Fudan University, Shanghai 
      200237, China.
FAU - Tan, Jing
AU  - Tan J
AD  - Shanghai First Maternity and Infant Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Fang, Guanghong
AU  - Fang G
AD  - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, Shanghai 200237, China.
FAU - Ji, Honglei
AU  - Ji H
AD  - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, Shanghai 200237, China.
FAU - Miao, Maohua
AU  - Miao M
AD  - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, Shanghai 200237, China.
FAU - Tian, Yuan
AU  - Tian Y
AD  - Department of Health Management, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University, Shanghai 200062, China.
FAU - Hu, Hui
AU  - Hu H
AD  - Harvard Medical School, Brigham and Women's Hospital, Channing Division of 
      Network Medicine, USA.
FAU - Cao, Wencheng
AU  - Cao W
AD  - Hubei Provincial Key Laboratory of Applied Toxicology, National Reference 
      Laboratory of Dioxin, Hubei Provincial Center for Disease Control and Prevention, 
      Wuhan, Hubei 430079, China.
FAU - Liang, Hong
AU  - Liang H
AD  - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, Shanghai 200237, China. Electronic address: 
      lianghong@sibpt.com.
FAU - Yuan, Wei
AU  - Yuan W
AD  - NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and 
      Pharmaceutical Technologies, Shanghai 200237, China.
LA  - eng
PT  - Journal Article
DEP - 20220628
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids
MH  - Bayes Theorem
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Cohort Studies
MH  - *Environmental Pollutants/toxicity
MH  - Female
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Infant
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Prospective Studies
MH  - *Sleep Wake Disorders
OTO - NOTNLM
OT  - Children
OT  - Cohort study
OT  - Neurobehavior
OT  - Perfluoroalkyl substances
OT  - Prenatal exposure
EDAT- 2022/07/02 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/07/01 18:32
PHST- 2022/03/21 00:00 [received]
PHST- 2022/06/20 00:00 [revised]
PHST- 2022/06/25 00:00 [accepted]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/07/01 18:32 [entrez]
AID - S0147-6513(22)00658-3 [pii]
AID - 10.1016/j.ecoenv.2022.113818 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2022 Aug;241:113818. doi: 10.1016/j.ecoenv.2022.113818. 
      Epub 2022 Jun 28.