PMID- 35777582
OWN - NLM
STAT- MEDLINE
DCOM- 20220726
LR  - 20220728
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 305
DP  - 2022 Sep 15
TI  - Urine protein in patients with type I hypersensitivity is indicative of 
      reversible renal tube injury.
PG  - 120735
LID - S0024-3205(22)00435-0 [pii]
LID - 10.1016/j.lfs.2022.120735 [doi]
AB  - AIMS: In our clinical work, some patients with type I hypersensitivity could be 
      detected protein in their urine. This study focused on the early renal injury in 
      patients with type I hypersensitivity. MAIN METHODS: From 43 type I 
      hypersensitivity patients with proteinuria, 10 patients were randomly selected 
      for mass spectrometry analysis of 24-h urine together with 5 healthy volunteers. 
      Mice were vaccinated with Dermatophagoides farina (Der f) and ovalbumin (OVA) 
      were used as antigen to establish the type I hypersensitivity animal models. KEY 
      FINDINGS: The urine protein of hypersensitivity patients was significantly 
      increased in the alpha-1-microglobulin/ bikunin precursor (Protein AMBP) 
      (t = 3.140, P = 0.008), retinol binding protein 4 (RBP4) (t = 2.426, P = 0.031), 
      kininogen-1 (t = 2.501, P = 0.027), and transferrin appeared only in patients' 
      urine. After immunizing mice with antigens, significant increases of the total 
      serum immunoglobulin E (IgE) were observed in both Der f (86.92 +/- 36.01 U/mL, 
      t = 5.231, P = 0.0004) and OVA group (34.65 +/- 24.72 U/mL, t = 2.891, P = 0.0161) 
      compared with the negative control group (2.68 +/- 0.47 U/mL). Meanwhile, definite 
      eosinophil infiltration around the impaired renal tubules as well as the bronchus 
      in Der f mice were observed, and urine protein appeared. After stopping the 
      allergen stimulation, proteinuria disappeared. Instead, when the mice were 
      treated with the antigen again, proteinuria reappeared. SIGNIFICANCE: Our 
      findings suggest that renal tubular damage in patients with type I 
      hypersensitivity is reversible, and proteinuria disappears with allergy symptoms 
      remission.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Cao, Yong
AU  - Cao Y
AD  - School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Shao, Li
AU  - Shao L
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Xin, Mei
AU  - Xin M
AD  - Department of Nuclear Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Zhang, Yilun
AU  - Zhang Y
AD  - School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Xu, Yanhua
AU  - Xu Y
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Song, Yang
AU  - Song Y
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Lu, Hui
AU  - Lu H
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Wang, Yiwei
AU  - Wang Y
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Xia, Ying
AU  - Xia Y
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Zhang, Meixing
AU  - Zhang M
AD  - School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Guo, Yinshi
AU  - Guo Y
AD  - Department of Allergy, Renji Hospital Affiliated to Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Wang, Lianyun
AU  - Wang L
AD  - School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 
      Shanghai, China; Department of Allergy, Renji Hospital Affiliated to Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Qiao, Zhongdong
AU  - Qiao Z
AD  - School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 
      Shanghai, China. Electronic address: zdqiao@sjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220628
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Allergens)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Humans
MH  - *Hypersensitivity/complications
MH  - Hypersensitivity, Immediate
MH  - Immunoglobulin E
MH  - *Kidney
MH  - Mice
MH  - Ovalbumin
MH  - *Proteinuria
MH  - Retinol-Binding Proteins, Plasma
OTO - NOTNLM
OT  - Proteinuria
OT  - Renal damage
OT  - Type I hypersensitivity
EDAT- 2022/07/02 06:00
MHDA- 2022/07/27 06:00
CRDT- 2022/07/01 19:25
PHST- 2021/12/05 00:00 [received]
PHST- 2022/04/07 00:00 [revised]
PHST- 2022/06/23 00:00 [accepted]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/07/27 06:00 [medline]
PHST- 2022/07/01 19:25 [entrez]
AID - S0024-3205(22)00435-0 [pii]
AID - 10.1016/j.lfs.2022.120735 [doi]
PST - ppublish
SO  - Life Sci. 2022 Sep 15;305:120735. doi: 10.1016/j.lfs.2022.120735. Epub 2022 Jun 
      28.