PMID- 35778316
OWN - NLM
STAT- MEDLINE
DCOM- 20220803
LR  - 20220808
IS  - 1499-3872 (Print)
VI  - 21
IP  - 4
DP  - 2022 Aug
TI  - High nuclear ABCG1 expression is a poor predictor for hepatocellular carcinoma 
      patient survival.
PG  - 370-377
LID - S1499-3872(22)00141-2 [pii]
LID - 10.1016/j.hbpd.2022.06.009 [doi]
AB  - BACKGROUND: ATP-binding cassette transporter G1 (ABCG1) regulates cellular 
      cholesterol homeostasis and plays a significant role in tumor immunity. But, for 
      hepatocellular carcinoma (HCC), the role of ABCG1 has not been investigated. 
      Thus, the aim of this study was to evaluate the prognostic value and 
      clinicopathological significance of ABCG1 in HCC. METHODS: One hundred and four 
      adult patients with HCC were enrolled, and ABCG1 expression in paired HCC 
      specimens was determined by immunohistochemistry. All these patients were 
      stratified by ABCG1 expression, Kaplan-Meier analysis was used to compare the 
      overall survival (OS) and recurrence-free survival (RFS), and Cox regression 
      analysis was used to determine independent predictors of tumor recurrence. 
      RESULTS: Upregulation of ABCG1 was observed in HCC samples compared to matched 
      tumor-adjacent tissues. Patients with high nuclear ABCG1 expression had lower OS 
      and RFS (P = 0.012 and P = 0.020, respectively). High nuclear ABCG1 expression 
      was related to larger tumor size (P = 0.004) and tumor recurrence (P = 0.027). 
      Although ABCG1 was expressed in the cytoplasm, cytosolic expression could not 
      predict the outcome in patients with HCC. A new stratification pattern was 
      established based on the heterogenous ABCG1 expression pattern: high risk 
      (High(nucleus)/Low(cytosol)), moderate risk (High(nucleus)/High(cytosol) or 
      Low(nucleus)/Low(cytosol)), and low risk (Low(nucleus)/High(cytosol)). This 
      ABCG1-based risk stratification could distinguish the different OS and RFS in 
      patients with HCC. Multivariate Cox regression analysis indicated that ABCG1 high 
      risk was an independent predictor of poor RFS (P = 0.015). CONCLUSIONS: High 
      nuclear ABCG1 expression indicates poor prognosis in patients with HCC. 
      Asymmetric distribution of ABCG1 in the nucleus and cytoplasm may have an 
      important role in tumor recurrence.
CI  - Copyright (c) 2022 First Affiliated Hospital, Zhejiang University School of 
      Medicine in China. Published by Elsevier B.V. All rights reserved.
FAU - Xi, Bin
AU  - Xi B
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China.
FAU - Luo, Fang-Zhou
AU  - Luo FZ
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China.
FAU - He, Bin
AU  - He B
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Radiotherapy, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou 310003, China.
FAU - Li, Ze-Kuan
AU  - Li ZK
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China.
FAU - Lai, Ming-Chun
AU  - Lai MC
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China.
FAU - Zheng, Shu-Sen
AU  - Zheng SS
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The 
      First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 
      310003, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry 
      of Public Health, Zhejiang University, Hangzhou 310003, China. Electronic 
      address: shusenzheng@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220623
PL  - Singapore
TA  - Hepatobiliary Pancreat Dis Int
JT  - Hepatobiliary & pancreatic diseases international : HBPD INT
JID - 101151457
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - Adult
MH  - Biomarkers, Tumor/analysis
MH  - *Carcinoma, Hepatocellular/pathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Liver Neoplasms/pathology
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
OTO - NOTNLM
OT  - ATP-binding cassette transporter G1
OT  - Hepatocellular carcinoma
OT  - Overall survival
OT  - Prognostic factor
OT  - Progression-free survival
EDAT- 2022/07/02 06:00
MHDA- 2022/08/04 06:00
CRDT- 2022/07/01 22:14
PHST- 2021/12/06 00:00 [received]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/08/04 06:00 [medline]
PHST- 2022/07/01 22:14 [entrez]
AID - S1499-3872(22)00141-2 [pii]
AID - 10.1016/j.hbpd.2022.06.009 [doi]
PST - ppublish
SO  - Hepatobiliary Pancreat Dis Int. 2022 Aug;21(4):370-377. doi: 
      10.1016/j.hbpd.2022.06.009. Epub 2022 Jun 23.