PMID- 35778430
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20220908
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jul 1
TI  - Clinical characteristics of idiopathic interstitial pneumonias with 
      anti-Ro52/tripartite motif-containing 21 antibodies.
PG  - 11122
LID - 10.1038/s41598-022-15321-4 [doi]
LID - 11122
AB  - Antibodies to Ro52/tripartite motif-containing 21 (TRIM21), referred to as 
      anti-Ro52, are found in patients diagnosed with diverse systemic autoimmune 
      rheumatic disease and associated with interstitial lung diseases. However, little 
      is known about the clinical characteristics of anti-Ro52 in patients with 
      idiopathic interstitial pneumonias (IIPs). We aimed to analyze the prevalence, 
      co-existent autoantibodies, and clinical characteristics of anti-Ro52 in patients 
      with IIP. The study enrolled 288 patients diagnosed with IIP. Clinical, 
      laboratory and radiographic findings of IIP patients were compared between 
      anti-Ro52 positives and negatives. Anti-Ro52 (20/288; 6.9%), anti-ARS (18/288; 
      6.3%), and anti-Ro60/SS-A (16/288; 5.6%) were the most common autoantibodies 
      detected in IIP patients. Among 20 IIP patients who had anti-Ro52, anti-ARS was 
      present in 8 (40%) patients. The criteria for interstitial pneumonia with 
      autoimmune features (IPAF) were significantly better fulfilled by patients with 
      anti-Ro52 than those without (P = 0.001). Meeting serological domain (P < 0.001) 
      and Raynaud's phenomenon (P = 0.009) were significantly more common in the 
      anti-Ro52-positive patients. Anti-Ro52-positive IIP patients have clinical 
      features consistent with IPAF. Anti-Ro52 may have an important role in detecting 
      the autoimmune phenotype in IIP patients.
CI  - (c) 2022. The Author(s).
FAU - Tahara, Masahiro
AU  - Tahara M
AD  - Department of Respiratory Medicine, University of Occupational and Environmental 
      Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, 
      Japan.
FAU - Sakamoto, Noriho
AU  - Sakamoto N
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Satoh, Minoru
AU  - Satoh M
AD  - Department of Clinical Nursing, School of Health Sciences, University of 
      Occupational and Environmental Health, Japan, Kitakyushu, Japan.
FAU - Ishimoto, Hiroshi
AU  - Ishimoto H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Yura, Hirokazu
AU  - Yura H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Yamasaki, Kei
AU  - Yamasaki K
AD  - Department of Respiratory Medicine, University of Occupational and Environmental 
      Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, 
      Japan.
FAU - Kido, Takashi
AU  - Kido T
AD  - Department of Respiratory Medicine, University of Occupational and Environmental 
      Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, 
      Japan.
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
FAU - Fujino, Yoshihisa
AU  - Fujino Y
AD  - Department of Environmental Epidemiology, Institute of Industrial Ecological 
      Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, 
      Japan.
FAU - Hasegawa, Tomoko
AU  - Hasegawa T
AD  - Department of Clinical Nursing, School of Health Sciences, University of 
      Occupational and Environmental Health, Japan, Kitakyushu, Japan.
FAU - Tanaka, Shin
AU  - Tanaka S
AD  - Department of Human, Information and Life Sciences, School of Health Sciences, 
      University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
FAU - Yatera, Kazuhiro
AU  - Yatera K
AD  - Department of Respiratory Medicine, University of Occupational and Environmental 
      Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, 
      Japan. yatera@med.uoeh-u.ac.jp.
FAU - Mukae, Hiroshi
AU  - Mukae H
AD  - Department of Respiratory Medicine, Nagasaki University Graduate School of 
      Biomedical Sciences, Nagasaki, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220701
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies
MH  - *Clinical Laboratory Services
MH  - Humans
MH  - *Idiopathic Interstitial Pneumonias
MH  - Laboratories, Clinical
MH  - Protein Domains
PMC - PMC9249750
COIS- The authors declare no competing interests.
EDAT- 2022/07/02 06:00
MHDA- 2022/07/08 06:00
PMCR- 2022/07/01
CRDT- 2022/07/01 23:18
PHST- 2021/11/22 00:00 [received]
PHST- 2022/06/22 00:00 [accepted]
PHST- 2022/07/01 23:18 [entrez]
PHST- 2022/07/02 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - 10.1038/s41598-022-15321-4 [pii]
AID - 15321 [pii]
AID - 10.1038/s41598-022-15321-4 [doi]
PST - epublish
SO  - Sci Rep. 2022 Jul 1;12(1):11122. doi: 10.1038/s41598-022-15321-4.