PMID- 35779890
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20221005
IS  - 1988-561X (Electronic)
IS  - 1699-8855 (Linking)
VI  - 55
IP  - 3
DP  - 2022 Jul-Sep
TI  - [Histological, immunohistochemical and molecular study of a paratesticular 
      dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like 
      features].
PG  - 212-217
LID - S1699-8855(21)00068-4 [pii]
LID - 10.1016/j.patol.2021.07.002 [doi]
AB  - We report the histological, immunohistochemical, and molecular findings of a 
      dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like 
      features occurring in the paratesticular region. Histologically, the 
      dedifferentiated component closely resembled an inflammatory myofibroblastic 
      tumor. The neoplastic cells were positive for smooth muscle actin with focal 
      CD56, CD99, Bcl2 and EMA expression. WT1, calretinin, myogenin, CK(AE1/AE3), 
      desmin, H-caldesmon, CD34, ALK, CKIT, DOG1, MUC4 and STAT6 were negative. MDM2 
      showed diffuse and strong nuclear positivity in neoplastic cells and fluorescence 
      in situ hybridization (FISH) revealed amplified MDM2 (high level) but no SYT 
      rearrangement. Although a lipomatous component was evident macroscopically, 
      well-differentiated liposarcomatous components were not evident in the section 
      examined. Dedifferentiated liposarcoma can have prominent inflammatory 
      myofibroblastic tumor-like features. Pathologists should be aware of this 
      histological variant in order to avoid misdiagnosing dedifferentiated liposarcoma 
      as inflammatory myofibroblastic tumor or other spindle cell tumors which have 
      different behavioral patterns and treatment requirements.
CI  - Copyright (c) 2021 Sociedad Espanola de Anatomia Patologica. Publicado por Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Machado, Isidro
AU  - Machado I
AD  - Departamento de Patologia, Instituto Valenciano de Oncologia, Valencia, Espana; 
      Departamento de Patologia, Patologika Laboratorio, Hospital Quiron-Salud, 
      Valencia, Espana. Electronic address: isidro.machado@uv.es.
FAU - Marti Ibor, Encarnacion
AU  - Marti Ibor E
AD  - Departamento de Patologia, Patologika Laboratorio, Hospital Quiron-Salud, 
      Valencia, Espana; Departamento de Patologia, Hospital Peset Alexandre, Valencia, 
      Espana.
FAU - Berbegall, Ana P
AU  - Berbegall AP
AD  - Departamento de Patologia, Patologika Laboratorio, Hospital Quiron-Salud, 
      Valencia, Espana.
FAU - Alcacer Fernandez-Coronado, Javier
AU  - Alcacer Fernandez-Coronado J
AD  - Departamento de Patologia, Patologika Laboratorio, Hospital Quiron-Salud, 
      Valencia, Espana.
FAU - Claramunt, Reyes
AU  - Claramunt R
AD  - Departamento de Biologia Molecular, Instituto Valenciano de Oncologia, Valencia, 
      Espana.
FAU - Duarte Novo, Jose Enrique
AU  - Duarte Novo JE
AD  - Servicio de Urologia, Hospital San Rafael, A Coruna, Espana.
FAU - Mosquera Reboredo, Juan
AU  - Mosquera Reboredo J
AD  - Departamento de Patologia, Hospital San Rafael, A Coruna, Espana.
FAU - Concha Lopez, Angel
AU  - Concha Lopez A
AD  - Departamento de Patologia, Hospital San Rafael, A Coruna, Espana.
FAU - Alcacer Garcia, Javier
AU  - Alcacer Garcia J
AD  - Departamento de Patologia, Patologika Laboratorio, Hospital Quiron-Salud, 
      Valencia, Espana.
LA  - spa
PT  - Case Reports
TT  - Liposarcoma desdiferenciado paratesticular simulando un tumor miofibroblastico 
      inflamatorio. Estudio histologico, inmunohistoquimico y molecular.
DEP - 20211007
PL  - Spain
TA  - Rev Esp Patol
JT  - Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de 
      Anatomia Patologica y de la Sociedad Espanola de Citologia
JID - 100885154
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Antigens, CD34
MH  - Chromosome Aberrations
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Lipoma
MH  - *Liposarcoma
OTO - NOTNLM
OT  - Amplificacion MDM2
OT  - Dedifferentiated liposarcoma
OT  - FISH
OT  - Histology
OT  - Histologia
OT  - Immunohistochemistry
OT  - Inmunohistoquimica
OT  - Liposarcoma desdiferenciado
OT  - MDM2 amplification
EDAT- 2022/07/03 06:00
MHDA- 2022/07/08 06:00
CRDT- 2022/07/02 21:03
PHST- 2021/04/18 00:00 [received]
PHST- 2021/06/26 00:00 [revised]
PHST- 2021/07/04 00:00 [accepted]
PHST- 2022/07/02 21:03 [entrez]
PHST- 2022/07/03 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
AID - S1699-8855(21)00068-4 [pii]
AID - 10.1016/j.patol.2021.07.002 [doi]
PST - ppublish
SO  - Rev Esp Patol. 2022 Jul-Sep;55(3):212-217. doi: 10.1016/j.patol.2021.07.002. Epub 
      2021 Oct 7.