PMID- 35781797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220921
IS  - 1309-0399 (Print)
IS  - 1309-0380 (Electronic)
IS  - 1309-0380 (Linking)
VI  - 23
IP  - 3
DP  - 2022 Sep 5
TI  - Effects of stem cells and amniotic fluid on uterus and ovaries in a rat model of 
      abdominal adhesions: a controlled study.
PG  - 154-166
LID - 10.4274/jtgga.galenos.2022.2022-1-14 [doi]
AB  - OBJECTIVE: This study aimed to compare the effects of human umbilical cord 
      mesenchymal stem cells (hUCMSCs), amniotic fluid (AF), and a combination of both 
      on the uterus and ovaries in a rat model of abdominal adhesions. MATERIAL AND 
      METHODS: This study was designed as a controlled study. Four groups, each 
      consisting of six rats, were randomly formed. One group was designated as the 
      control (CNT). hUCMSCs - applied (hUCSC), AF-applied (AMN), and a combination of 
      both (hUCSC + AMN) were the experimental groups. All rats were given 
      intraperitoneal talc powder to create adhesions. After 21 days, animals in 
      experimental groups were further treated with hUCMSC, AF or a combination of 
      these. RESULTS: There was a statistically significant difference in primordial 
      follicle count, endometrial gland number, and endometrial blood vessel count 
      (p<0.05). AMN provided the best results in the endometrial vessel and primordial 
      follicle count. The average endometrial gland count in AMN and hUCSC + AMN was 
      similarly higher than CNT and hUCSC alone. CONCLUSION: There were significantly 
      higher for counts for endometrial glands, endometrial blood vessels, and 
      primordial follicles in the hUCSC, AMN and hUCSC + AMN groups compared to 
      controls. Animals in the AMN group had the best result for endometrial vessel and 
      highest primordial follicle count.
FAU - Ganime Aygun, Elif
AU  - Ganime Aygun E
AUID- ORCID: 0000-0003-3737-7250
AD  - Clinic of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, 
      Atakent Hospital, Istanbul, Turkey
FAU - Tumentemur, Gamze
AU  - Tumentemur G
AUID- ORCID: 0000-0002-3114-634X
AD  - Department of Anatomy, Acibadem Mehmet Ali Aydinlar University Vocational School 
      of Health Services, Istanbul, Turkey
LA  - eng
PT  - Journal Article
DEP - 20220705
PL  - Turkey
TA  - J Turk Ger Gynecol Assoc
JT  - Journal of the Turkish German Gynecological Association
JID - 101272522
PMC - PMC9450920
OTO - NOTNLM
OT  - Amniotic fluid
OT  - case-control studies
OT  - infertility
OT  - ovaries
OT  - rats
OT  - stem cells
OT  - uterus
OT  - surgical adhesions
COIS- Conflict of Interest: No conflict of interest is declared by the authors.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/06 06:01
PMCR- 2022/09/05
CRDT- 2022/07/05 09:32
PHST- 2022/07/05 09:32 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/06 06:01 [medline]
PHST- 2022/09/05 00:00 [pmc-release]
AID - 52387 [pii]
AID - 10.4274/jtgga.galenos.2022.2022-1-14 [doi]
PST - ppublish
SO  - J Turk Ger Gynecol Assoc. 2022 Sep 5;23(3):154-166. doi: 
      10.4274/jtgga.galenos.2022.2022-1-14. Epub 2022 Jul 5.