PMID- 35783134 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 1663-4365 (Print) IS - 1663-4365 (Electronic) IS - 1663-4365 (Linking) VI - 14 DP - 2022 TI - Increased Levels of Serum IL-15 and TNF-beta Indicate the Progression of Human Intracranial Aneurysm. PG - 903619 LID - 10.3389/fnagi.2022.903619 [doi] LID - 903619 AB - OBJECTIVE: Existing evidence suggests that chronic inflammation promotes the progression of human intracranial aneurysm (IA) and many cytokines have been detected to participate in the process of inflammation. However, rare cytokines in plasma have been used as proxies for progression of IA. This study aimed to identify novel cytokines as biomarkers to predict the development of IA. METHODS: Patients with unruptured intracranial aneurysms (UIAs) undergoing microsurgical clipping were prospectively recruited from January 2017 to June 2020 and were separated into two groups based on their ELAPSS score (low risk group < 10, intermediate-high risk group >/= 10). Propensity score matching (PSM) was used to reduce imbalances in the baseline characteristics between groups. All blood samples were collected before surgery. A human serum 48-cytokines examination was performed to analyze the concentrations of serological cytokines. Clinical data and cytokines were compared between groups. RESULTS: A total of 184 patients were enrolled in this study. The low risk group contained 77 patients and 107 patients were included in the intermediate-high risk group. Finally, there were 69 patients in each group after PSM with a matching rate of 1:1. The concentrations of 3 serum cytokines were significantly increased in intermediate-high risk patients, namely, interleukin-15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor-beta (TNF-beta) (P < 0.05, |log(2) fold change| > 2). The result of receiver operator characteristic (ROC)curve revealed that TNF-beta had the highest predictive accuracy, with an area under the curve (AUC) value of 0.725 [95% confidence interval (CI) 0.639-0.811, P < 0.001] followed by IL-15 (AUC = 0.691, 95% CI 0.602-0.781, P < 0.001) and MCP-1 (AUC = 0.661, 95% CI 0.569-0.753, P = 0.001). Multivariate logistic analysis demonstrated high IL-15 [odds ratio (OR), 3.23; 95% CI, 1.47-7.12; P = 0.004] and high TNF-beta (OR, 8.30; 95% CI, 3.25-21.25; P < 0.001) as the risk factors that correlated with intermediate-high risk of IA progression. CONCLUSION: UIA patients with intermediate-high growth risk exhibited increased serum levels of IL-15, MCP-1, and TNF-beta. Serum IL-15, and TNF-beta could serve as biomarkers to predict the progression of UIAs. CI - Copyright (c) 2022 Yang, Liu, Yang, Wu and Wang. FAU - Yang, Shuzhe AU - Yang S AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. FAU - Liu, Qingyuan AU - Liu Q AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. FAU - Yang, Junhua AU - Yang J AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. FAU - Wu, Jun AU - Wu J AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. FAU - Wang, Shuo AU - Wang S AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - China National Clinical Research Center for Neurological Diseases, Beijing, China. AD - Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. AD - Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China. LA - eng PT - Journal Article DEP - 20220617 PL - Switzerland TA - Front Aging Neurosci JT - Frontiers in aging neuroscience JID - 101525824 PMC - PMC9247574 OTO - NOTNLM OT - IL-15 OT - TNF-beta OT - aneurysm progression OT - serum cytokines OT - unruptured intracranial aneurysm COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer YW declared a shared parent affiliation with the authors to the handling editor at the time of review. EDAT- 2022/07/06 06:00 MHDA- 2022/07/06 06:01 PMCR- 2022/01/01 CRDT- 2022/07/05 10:03 PHST- 2022/03/24 00:00 [received] PHST- 2022/05/31 00:00 [accepted] PHST- 2022/07/05 10:03 [entrez] PHST- 2022/07/06 06:00 [pubmed] PHST- 2022/07/06 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fnagi.2022.903619 [doi] PST - epublish SO - Front Aging Neurosci. 2022 Jun 17;14:903619. doi: 10.3389/fnagi.2022.903619. eCollection 2022.