PMID- 35783657
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Diagnostic Value of Spectral-Domain Optical Coherence Tomography for Polypoidal 
      Choroidal Vasculopathy: A Systematic Review and Meta-Analysis.
PG  - 878946
LID - 10.3389/fmed.2022.878946 [doi]
LID - 878946
AB  - PURPOSE: To evaluate the diagnostic value of spectral-domain optical coherence 
      tomography (SD-OCT) for polypoidal choroidal vasculopathy (PCV). METHODS: A 
      search of electronic databases was conducted from 2010 to 2021 to review the 
      relevant literature on SD-OCT to identify PCV and other lesions causing serious 
      or serosanguinous retinal pigment epithelial detachment (PED), specifically 
      neovascular age-related macular degeneration (nvAMD). The QUADAS-2 scale was used 
      to evaluate the quality of the literature. We performed a meta-analysis, 
      including heterogeneity tests, analyze and synthesize the study data, 
      meta-regression analysis, subgroup analysis, Fagan's plot, sensitivity analysis 
      and publication bias tests. RESULTS: A total of 12 related studies involving 
      1,348 eyes were included in this study, and the random-effects model was used for 
      meta-analysis. The results showed that the pooled sensitivity of SD-OCT in the 
      diagnosis of PCV was 0.87 (95% CI: 0.84-0.89), the pooled specificity was 0.83 
      (95% CI: 0.80-0.86), and the pooled positive/negative likelihood ratios were 5.38 
      (95% CI: 3.28-8.80) and 0.16 (95% CI: 0.10-0.25), respectively. The diagnostic 
      odds ratio (DOR) was 36.07 (95% CI: 15.98-81.40), and the area under the sROC 
      curve (AUC) was 0.9429. When the pre-test probability was set at 20%, the 
      post-test positive and negative probabilities were 58% and 4%, respectively. 
      Meta-regression indicated that race was the primary source of heterogeneity (P 
      <0.05). The Deeks' funnel plot showed no significant publication bias in this 
      study (P>0.05). CONCLUSION: SD-OCT has high sensitivity and specificity for the 
      diagnosis of PCV, as well as significant clinical applicability. Since color 
      fundus photography (CFP) is more clinically available and can improve the 
      diagnostic efficacy, we recommend SD-OCT combined with CFP to diagnose PCV, 
      especially without indocyanine green angiography (ICGA). SYSTEMATIC REVIEW 
      REGISTRATION: https://inplasy.com/inplasy-2021-12-0048/, identifier: 
      INPLASY2021120048.
CI  - Copyright (c) 2022 Jiang and Qi.
FAU - Jiang, Yang
AU  - Jiang Y
AD  - Department of Ophthalmology, Tianjin Baodi Hospital, Tianjin, China.
AD  - Baodi Clinical College, Tianjin Medical University, Tianjin, China.
FAU - Qi, Shixin
AU  - Qi S
AD  - Department of Ophthalmology, Tianjin Baodi Hospital, Tianjin, China.
AD  - Baodi Clinical College, Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Systematic Review
DEP - 20220615
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9242399
OTO - NOTNLM
OT  - diagnostic value
OT  - meta-analysis
OT  - polypoidal choroidal vasculopathy
OT  - sensitivity
OT  - specificity
OT  - spectral-domain optical coherence tomography
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/06 06:01
PMCR- 2022/06/15
CRDT- 2022/07/05 10:13
PHST- 2022/02/18 00:00 [received]
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/07/05 10:13 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/06 06:01 [medline]
PHST- 2022/06/15 00:00 [pmc-release]
AID - 10.3389/fmed.2022.878946 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Jun 15;9:878946. doi: 10.3389/fmed.2022.878946. 
      eCollection 2022.