PMID- 35784528
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20221207
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Association Between High-Sensitivity C-Reactive Protein and Diabetic Kidney 
      Disease in Patients With Type 2 Diabetes Mellitus.
PG  - 885516
LID - 10.3389/fendo.2022.885516 [doi]
LID - 885516
AB  - OBJECTIVE: High-sensitivity C-reactive protein (hs-CRP) is an inflammatory 
      marker. This study aimed to identify the correlation between hs-CRP levels and 
      diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). 
      MATERIALS/METHODS: This cross-sectional and observational study included 927 
      patients with T2DM. We collected the data of patients based on their medical 
      data, including sociodemographic characteristics, concomitant diseases, 
      laboratory results, and medical therapy. Multivariate logistic regression 
      analysis was conducted to assess the relationship between hs-CRP levels and DKD. 
      A restricted cubic spline (RCS) was used to assess the correlation of hs-CRP 
      levels on a continuous scale with the DKD. RESULTS: In total, 927 patients were 
      recruited in our study. The median age of the recruited patients was 55 years, 
      and there were 346 female patients and 581 male patients. The hs-CRP levels were 
      evidently higher in patients with DKD than those without DKD. After adjusting for 
      age, sex, diastolic blood pressure, systolic blood pressure, body mass index, 
      neck circumference, waist circumference, hypertension, duration of diabetes, 
      common carotid artery plaque, fasting plasma glucose, glycated hemoglobin, 
      hemoglobin, erythrocyte, leukocyte, gamma-glutamyl transferase, albumin, urea 
      nitrogen, uric acid and triglyceride, a significant increase in the odds ratios 
      (ORs) for DKD in the fourth hs-CRP quartile compared with the first quartile was 
      observed (P value for trend= 0.003), and the ORs (95% confidence intervals) in 
      the fourth quartile of hs-CRP were 1.968 (1.244-3.114) for DKD compared to the 
      first quartile.. Moreover, the RCS curves presented a positive association 
      between hs-CRP and DKD in total subjects, male subjects and female subjects, 
      respectively. CONCLUSIONS: The results of our study indicated that hs-CRP levels 
      were significantly and positively correlated with the presence of DKD, which may 
      provide predictive and diagnostic values in clinical practice.
CI  - Copyright (c) 2022 Tang, Cao, Wei, Zhen, Liu, Wang, Fan and Peng.
FAU - Tang, Min
AU  - Tang M
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Cao, Han
AU  - Cao H
AD  - Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
AD  - Department of Endocrinology, Songjiang District Central Hospital, Shanghai, 
      China.
FAU - Wei, Xiao-Hui
AU  - Wei XH
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhen, Qin
AU  - Zhen Q
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Liu, Fang
AU  - Liu F
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Wang, Yu-Fan
AU  - Wang YF
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Fan, Neng-Guang
AU  - Fan NG
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
FAU - Peng, Yong-De
AU  - Peng YD
AD  - Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220616
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (CRP protein, human)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Receptors, Immunologic)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - *C-Reactive Protein/analysis
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Nephropathies/etiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Receptors, Immunologic
PMC - PMC9245013
OTO - NOTNLM
OT  - diabetic kidney disease
OT  - high-sensitivity C-reactive protein
OT  - inflammation
OT  - microvascular complications
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/07 06:00
PMCR- 2022/01/01
CRDT- 2022/07/05 10:26
PHST- 2022/02/28 00:00 [received]
PHST- 2022/05/09 00:00 [accepted]
PHST- 2022/07/05 10:26 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.885516 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jun 16;13:885516. doi: 
      10.3389/fendo.2022.885516. eCollection 2022.