PMID- 35784566 OWN - NLM STAT- MEDLINE DCOM- 20220706 LR - 20220729 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - The Burden of Diabetes-Related Chronic Kidney Disease in China From 1990 to 2019. PG - 892860 LID - 10.3389/fendo.2022.892860 [doi] LID - 892860 AB - OBJECTIVE: To analyze the trends in disease burden of diabetes-related chronic kidney disease (CKD) by year, age, gender and types of diabetes in China from 1990 to 2019. METHODS: Data on prevalence, deaths and disability-adjusted life years (DALYs) for diabetes-related CKD were extracted from the Global Burden of Disease (GBD) 2019 study. Analyses were performed by year, age, gender and types of diabetes. RESULTS: In China, the numbers of deaths and DALYs of diabetes-related CKD continuously increased but the age-standardized rates (per 100,000 population) decreased over 30 years, in which the numbers of deaths and DALYs attributable to type 1 diabetes mellitus (T1DM)-related CKD barely changed and the age-standardized rates decreased over the years; and the number of deaths and DALYs attributable to type 2 diabetes mellitus (T2DM)-related CKD continuously increased, but the age-standardized rates also decreased. In 2019, 76.03 (58.24-95.61) thousand deaths and 2.13 (1.65-2.67) million DALYs were attributable to diabetes-related CKD, of which, T2DM accounted for 83.32% and 77.0% respectively, and T1DM accounted for the rest. Increasing gender disparity was seen, with males being more heavily impacted. The burden of diabetes-related CKD varied among different age groups, with the numbers of deaths and DALYs attributable to T1DM-related CKD peaking between 45 and 54 years of age and T2DM-related CKD peaking between 75 and 79 years of age; and the crude rates of deaths and DALYs attributable to T1DM-related CKD peaking between 70 and 79 years of age and 40 to 54 years of age, respectively, and T2DM-related CKD peaking over 90 years of age. Among neighboring and G20 countries, the burden of diabetes-related CKD in China was relatively controlled reflected by the ranking of adjusted death and DALYs rates. CONCLUSIONS: The burden of diabetes-related CKD in China worsens and shows gender disparities and different age distribution. Greater efforts are needed to improve the health outcomes of these patients, especially among males. CI - Copyright (c) 2022 Pan, Lin, Huang, Xu, Ye, Zhang, Hu, Jiang, Ren and Shan. FAU - Pan, Xiaowen AU - Pan X AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Lin, Xiling AU - Lin X AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Huang, Xin AU - Huang X AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Xu, Jingya AU - Xu J AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Ye, Lingxia AU - Ye L AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Zhang, Tianyue AU - Zhang T AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Hu, Shaoning AU - Hu S AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Jiang, Hongwei AU - Jiang H AD - Endocrine and Metabolic Disease Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology; Medical Key Laboratory of Hereditary Rare Diseases of Henan; Luoyang Sub-Center of National Clinical Research Center for Metabolic Diseases, Luoyang, China. FAU - Ren, Yuezhong AU - Ren Y AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. FAU - Shan, Peng-Fei AU - Shan PF AD - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. AD - Binjiang Institute of Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220615 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Adult MH - Aged, 80 and over MH - China/epidemiology MH - *Diabetes Mellitus, Type 1/complications/epidemiology MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Humans MH - Infant MH - Male MH - Quality-Adjusted Life Years MH - *Renal Insufficiency, Chronic/epidemiology/etiology PMC - PMC9240757 OTO - NOTNLM OT - China OT - chronic kidney disease OT - death OT - diabetes OT - disability-adjusted life years COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/07/06 06:00 MHDA- 2022/07/07 06:00 PMCR- 2022/01/01 CRDT- 2022/07/05 10:26 PHST- 2022/03/09 00:00 [received] PHST- 2022/04/20 00:00 [accepted] PHST- 2022/07/05 10:26 [entrez] PHST- 2022/07/06 06:00 [pubmed] PHST- 2022/07/07 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.892860 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2022 Jun 15;13:892860. doi: 10.3389/fendo.2022.892860. eCollection 2022.