PMID- 35785361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Diffusion-Weighted Lesions After Intracerebral Hemorrhage: Associated MRI 
      Findings.
PG  - 882070
LID - 10.3389/fneur.2022.882070 [doi]
LID - 882070
AB  - The current study aimed to investigate whether diffusion-weighted 
      imaging-positive (DWI+) lesions after acute intracerebral hemorrhage (ICH) are 
      associated with underlying small vessel disease (SVD) or linked to the acute ICH. 
      We included patients >/=18 years with spontaneous ICH confirmed on neuroimaging and 
      performed 3T MRIs after a median of 11 days (interquartile range [IQR] 6-43). 
      DWI+ lesions were assessed in relation to the hematoma (perihematomal vs. distant 
      and ipsilateral vs. contralateral). Differences in clinical characteristics, ICH 
      characteristics, and MRI markers of SVD between participants with or without DWI+ 
      lesions were investigated using non-parametric tests. We observed 54 DWI+ lesions 
      in 30 (22%) of the 138 patients (median age [IQR] 65 [55-73] years; 71% men, 59 
      lobar ICH) with available DWI images. We found DWI+ lesions ipsilateral (54%) and 
      contralateral (46%) to the ICH, and 5 (9%) DWI+ lesions were located in the 
      immediate perihematomal region. DWI+ lesion presence was associated with probable 
      CAA diagnosis (38 vs. 15%, p = 0.01) and larger ICH volumes (37 [8-47] vs. 12 
      [6-24] ml, p = 0.01), but not with imaging features of SVD. Our findings suggest 
      that DWI+ lesions after ICH are a feature of both the underlying SVD and 
      ICH-related mechanisms.
CI  - Copyright (c) 2022 Wiegertjes, Voigt, Jolink, Koemans, Schreuder, van Walderveen, 
      Wermer, Meijer, Duering, de Leeuw and Klijn.
FAU - Wiegertjes, Kim
AU  - Wiegertjes K
AD  - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, 
      Radboud University Medical Center, Nijmegen, Netherlands.
FAU - Voigt, Sabine
AU  - Voigt S
AD  - Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.
FAU - Jolink, Wilmar M T
AU  - Jolink WMT
AD  - Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
FAU - Koemans, Emma A
AU  - Koemans EA
AD  - Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.
FAU - Schreuder, Floris H B M
AU  - Schreuder FHBM
AD  - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, 
      Radboud University Medical Center, Nijmegen, Netherlands.
FAU - van Walderveen, Marianne A A
AU  - van Walderveen MAA
AD  - Department of Radiology, Leiden University Medical Center, Leiden, Netherlands.
FAU - Wermer, Marieke J H
AU  - Wermer MJH
AD  - Department of Neurology and Neurosurgery, University Medical Center Utrecht, 
      Brain Center, Utrecht University, Utrecht, Netherlands.
FAU - Meijer, Frederick J A
AU  - Meijer FJA
AD  - Department of Medical Imaging, Radboud University Medical Center, Nijmegen, 
      Netherlands.
FAU - Duering, Marco
AU  - Duering M
AD  - Department of Biomedical Engineering, Medical Image Analysis Center (MIAC AG) and 
      qbig, University of Basel, Basel, Switzerland.
FAU - de Leeuw, Frank-Erik
AU  - de Leeuw FE
AD  - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, 
      Radboud University Medical Center, Nijmegen, Netherlands.
FAU - Klijn, Catharina J M
AU  - Klijn CJM
AD  - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, 
      Radboud University Medical Center, Nijmegen, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20220615
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9240258
OTO - NOTNLM
OT  - cerebral amyloid angiopathy
OT  - diffusion-weighted imaging
OT  - intracerebral hemorrhage
OT  - magnetic resonance imaging
OT  - small vessel disease
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/06 06:01
PMCR- 2022/06/15
CRDT- 2022/07/05 10:37
PHST- 2022/02/23 00:00 [received]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/07/05 10:37 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/06 06:01 [medline]
PHST- 2022/06/15 00:00 [pmc-release]
AID - 10.3389/fneur.2022.882070 [doi]
PST - epublish
SO  - Front Neurol. 2022 Jun 15;13:882070. doi: 10.3389/fneur.2022.882070. eCollection 
      2022.