PMID- 35785528
OWN - NLM
STAT- MEDLINE
DCOM- 20220707
LR  - 20220725
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 10
IP  - 13
DP  - 2022 Jul
TI  - Influence of an energy deficient and low carbohydrate acute dietary manipulation 
      on iron regulation in young females.
PG  - e15351
LID - 10.14814/phy2.15351 [doi]
LID - e15351
AB  - Hepcidin is a liver-derived hormone that regulates iron metabolism. Recent 
      studies suggest that an energy-deficient diet or low carbohydrate (CHO) 
      availability may increase hepcidin in the absence of inflammation. The purpose of 
      the present study was to examine the impact of either an energy-deficient diet or 
      an ED diet with low CHO intake during three consecutive days on hepcidin 
      responses, hematological variables, and energy metabolism in young Japanese 
      women. Twenty-two young females were divided into two different groups, either an 
      energy-deficient with low CHO intake group (ED + LCHO; 2.0 +/- 0.3 g/kg/day CHO, 
      39%CHO, 1123 kcal/day) or an energy deficient with moderate CHO intake group (ED; 
      3.4 +/- 0.3 g/kg/day CHO, 63%CHO, 1162 kcal/day). During the three consecutive days 
      of the dietary intervention program, participants consumed only the prescribed 
      diet and maintained their habitual physical activity levels. Body composition, 
      substrate oxidation, iron metabolism, and inflammation were evaluated pre- and 
      post-intervention. Serum iron and ferritin levels were significantly elevated 
      following the intervention (p < 0.001, p = 0.003, respectively). Plasma 
      interleukin-6 (IL-6) levels did not change following the intervention. Serum 
      hepcidin levels significantly increased after the intervention (p = 0.002). 
      Relative change in hepcidin levels was significantly higher in the ED + LCHO 
      (264.3 +/- 87.2%) than in the ED group (68.9 +/- 22.1%, p = 0.048). Three consecutive 
      days of an energy-deficient diet increased fasting hepcidin levels. Moreover, 
      elevated hepcidin levels were further augmented when an energy-deficient diet was 
      combined with a lower CHO intake.
CI  - (c) 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Hayashi, Nanako
AU  - Hayashi N
AUID- ORCID: 0000-0002-1990-6123
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, 
      Shiga, Japan.
FAU - Ishibashi, Aya
AU  - Ishibashi A
AUID- ORCID: 0000-0001-5145-2638
AD  - Department of Life Science, The University of Tokyo, Meguro, Tokyo, Japan.
FAU - Iwata, Ayame
AU  - Iwata A
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, 
      Shiga, Japan.
FAU - Yatsutani, Haruka
AU  - Yatsutani H
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, 
      Shiga, Japan.
FAU - Badenhorst, Claire
AU  - Badenhorst C
AUID- ORCID: 0000-0002-8434-9730
AD  - School of Sports, Exercise and Nutrition, Massey University, Auckland, New 
      Zealand.
FAU - Goto, Kazushige
AU  - Goto K
AUID- ORCID: 0000-0002-9911-3229
AD  - Graduate School of Sport and Health Science, Ritsumeikan University, Kusatsu, 
      Shiga, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Hepcidins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Diet
MH  - Dietary Carbohydrates
MH  - Female
MH  - *Hepcidins
MH  - Humans
MH  - Inflammation
MH  - *Iron/metabolism
PMC - PMC9251860
OTO - NOTNLM
OT  - hepcidin
OT  - iron status
OT  - low carbohydrate availability
OT  - low energy availability
COIS- The authors declare there are no competing interests.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/08 06:00
PMCR- 2022/07/03
CRDT- 2022/07/05 10:53
PHST- 2022/05/10 00:00 [revised]
PHST- 2021/12/15 00:00 [received]
PHST- 2022/05/21 00:00 [accepted]
PHST- 2022/07/05 10:53 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/08 06:00 [medline]
PHST- 2022/07/03 00:00 [pmc-release]
AID - PHY215351 [pii]
AID - 10.14814/phy2.15351 [doi]
PST - ppublish
SO  - Physiol Rep. 2022 Jul;10(13):e15351. doi: 10.14814/phy2.15351.