PMID- 35785598
OWN - NLM
STAT- MEDLINE
DCOM- 20221025
LR  - 20221025
IS  - 1898-4002 (Electronic)
IS  - 1896-1126 (Linking)
VI  - 67
IP  - 2
DP  - 2022 Sep
TI  - Sphingomyelin profiling in patients with diabetes could be potentially useful as 
      differential diagnostics biomarker: A pilot study.
PG  - 250-256
LID - S1896-1126(22)00022-0 [pii]
LID - 10.1016/j.advms.2022.06.001 [doi]
AB  - PURPOSE: Autoimmune diabetes (AD) in adults includes both the classical form of 
      type 1 diabetes mellitus (T1DM) and latent autoimmune diabetes in adults (LADA). 
      LADA shares clinical and metabolic features with type 1 and type 2 diabetes 
      mellitus (T2DM). Ceramide (Cer) levels negatively correlate with insulin 
      sensitivity in humans and animal models. However, only a few studies have focused 
      on other sphingolipids, including sphingomyelin (SM). Therefore, we determined 
      sphingolipids in patients with newly diagnosed diabetes as possible diagnostic 
      biomarkers. MATERIALS AND METHODS: We evaluated sphingolipids in a cohort of 59 
      adults with newly diagnosed diabetes without prior hypoglycemic pharmacotherapy 
      to distinguish diabetes mellitus types and for precise LADA definition. All 
      patients with newly diagnosed diabetes were tested for the concentrations of 
      individual Cer and SM species by gas-liquid chromatography. The study included 
      healthy controls and patients with T1DM, T2DM and LADA. RESULTS: SM species were 
      significantly altered in patients with newly diagnosed diabetes compared to 
      healthy controls. SM-C16:0, C16:1, -C18:0, -C18:1, -C18:2, -C18:3, -C20:4, and 
      -C22:6 species were found to be significantly elevated in LADA patients. In 
      contrast, significant differences were observed for Cer species with saturated 
      acyl chains, especially Cer-C14:0, -C16:0, -C18:0 (AD and T2DM), -C22:0, and 
      -C24:0 (T1DM). Following ROC analysis, SM-C16:0, and particularly -C18:1, and 
      -C20:4 may be supportive diagnostic markers for LADA. CONCLUSION: SM profiling in 
      patients with newly diagnosed diabetes could be potentially helpful for 
      differential diagnosis of LADA, T1DM, and T2DM in more challenging cases.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Sokolowska, Emilia
AU  - Sokolowska E
AD  - Department of Experimental Pharmacology, Medical University of Bialystok, 
      Bialystok, Poland. Electronic address: emilia.sokolowska@umb.edu.pl.
FAU - Car, Halina
AU  - Car H
AD  - Department of Experimental Pharmacology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Fiedorowicz, Anna
AU  - Fiedorowicz A
AD  - Department of Experimental Pharmacology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Szelachowska, Malgorzata
AU  - Szelachowska M
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Milewska, Anna
AU  - Milewska A
AD  - Department of Statistics and Medical Informatics, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Wawrusiewicz-Kurylonek, Natalia
AU  - Wawrusiewicz-Kurylonek N
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Szumowski, Piotr
AU  - Szumowski P
AD  - Department of Nuclear Medicine, Medical University of Bialystok, Bialystok, 
      Poland.
FAU - Krzyzanowska-Grycel, Edyta
AU  - Krzyzanowska-Grycel E
AD  - Department of Experimental Pharmacology, Medical University of Bialystok, 
      Bialystok, Poland.
FAU - Poplawska-Kita, Anna
AU  - Poplawska-Kita A
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Zendzian-Piotrowska, Malgorzata
AU  - Zendzian-Piotrowska M
AD  - Department of Hygiene, Epidemiology and Ergonomics, Medical University of 
      Bialystok, Bialystok, Poland.
FAU - Chabowski, Adrian
AU  - Chabowski A
AD  - Department of Physiology, Medical University of Bialystok, Bialystok, Poland.
FAU - Kretowski, Adam
AU  - Kretowski A
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Siewko, Katarzyna
AU  - Siewko K
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland. Electronic address: 
      katarzynasiewko@o2.pl.
LA  - eng
PT  - Journal Article
DEP - 20220701
PL  - Netherlands
TA  - Adv Med Sci
JT  - Advances in medical sciences
JID - 101276222
RN  - 0 (Sphingomyelins)
RN  - 0 (Ceramides)
RN  - 0 (Sphingolipids)
RN  - 0 (Biomarkers)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Humans
MH  - Sphingomyelins
MH  - *Diabetes Mellitus, Type 1/diagnosis
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Pilot Projects
MH  - *Latent Autoimmune Diabetes in Adults
MH  - Ceramides/metabolism
MH  - Sphingolipids
MH  - Biomarkers
MH  - Hypoglycemic Agents
MH  - Autoantibodies
OTO - NOTNLM
OT  - Ceramide
OT  - LADA
OT  - Sphingomyelin
OT  - Type 1 diabetes
OT  - Type 2 diabetes
COIS- Declaration of competing interest The authors declare no conflicts of interest to 
      disclose for this study.
EDAT- 2022/07/06 06:00
MHDA- 2022/10/26 06:00
CRDT- 2022/07/05 10:59
PHST- 2021/10/12 00:00 [received]
PHST- 2022/02/21 00:00 [revised]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/10/26 06:00 [medline]
PHST- 2022/07/05 10:59 [entrez]
AID - S1896-1126(22)00022-0 [pii]
AID - 10.1016/j.advms.2022.06.001 [doi]
PST - ppublish
SO  - Adv Med Sci. 2022 Sep;67(2):250-256. doi: 10.1016/j.advms.2022.06.001. Epub 2022 
      Jul 1.