PMID- 35786288
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20221207
IS  - 1751-2441 (Electronic)
IS  - 1751-2433 (Linking)
VI  - 15
IP  - 5
DP  - 2022 May
TI  - The effect of inhaled corticosteroids on the outcomes of patients with COVID-19: 
      A systematic review and meta-analysis of randomized controlled trials.
PG  - 593-600
LID - 10.1080/17512433.2022.2094769 [doi]
AB  - BACKGROUND: The effect of inhaled corticosteroids (ICS) on the clinical outcomes 
      of patients with coronavirus disease 2019 (COVID-19) was not known. RESEARCH 
      DESIGN AND METHODS: Only phase 2 and 3 randomized clinical trials (RCTs) from 
      electronic databases that investigated ICS in the treatment of COVID-19 patients 
      were included. The outcomes of interest were the resolution of symptoms, risk of 
      hospitalization or urgent medical visit, mortality, and the incidence of adverse 
      events (AEs). RESULTS: Five RCTs involving 1243 patients who received ICS and 
      1526 patients with placebo or usual care were included. The ICS group had a 
      higher rate of symptom resolution than the control group at day 14 (risk ratio 
      [RR], 1.21; 95% confidence interval [CI], 1.12-1.30, p < 0.00001) and day 28 (RR, 
      1.12; 95% CI, 1.06-1.18, p < 0.0001). Additionally, the ICS group had a 
      significantly lower risk of needing urgent medical care or hospitalization than 
      the control group (RR, 0.15; 95% CI, 0.05-0.50; I2 = 0, p = 0.002). However, no 
      significant difference in the 28-day mortality rate. CONCLUSIONS: In patients 
      with mild-to-moderate COVID-19, ICS therapy improved symptom resolution, and 
      decreased the risk of needing urgent medical care or hospitalization.
FAU - Chen, Chao-Hsien
AU  - Chen CH
AUID- ORCID: 0000-0002-2176-3504
AD  - Division of Pulmonary, Department of Internal Medicine, MacKay Memorial Hospital, 
      Taipei, Taiwan.
AD  - Department of Medicine, MacKey Medical College, New Taipei, Taiwan.
FAU - Wang, Cheng-Yi
AU  - Wang CY
AUID- ORCID: 0000-0001-7426-0743
AD  - Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, 
      College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.
FAU - Wang, Ya-Hui
AU  - Wang YH
AUID- ORCID: 0000-0001-8118-3547
AD  - Medical Research Center, Cardinal Tien Hospital and School of Medicine, College 
      of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.
FAU - Chen, Ching-Yi
AU  - Chen CY
AUID- ORCID: 0000-0002-3320-1680
AD  - Division of Pulmonary Medicine, Department of Internal Medicine, E-Da Hospital, 
      I-Shou University, Kaohsiung, Taiwan.
FAU - Chen, Kuang-Hung
AU  - Chen KH
AD  - Department of Internal Medicine, National Taiwan University Hospital and College 
      of Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Lai, Chih-Cheng
AU  - Lai CC
AUID- ORCID: 0000-0002-6334-2388
AD  - Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical 
      Center, Tainan, Taiwan.
FAU - Wei, Yu-Feng
AU  - Wei YF
AUID- ORCID: 0000-0002-6380-3527
AD  - Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung, Taiwan.
AD  - School of Medicine for International Students, College of Medicine, and Institute 
      of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan.
FAU - Fu, Pin-Kuei
AU  - Fu PK
AUID- ORCID: 0000-0002-9416-4094
AD  - Department of Critical Care Medicine, Taichung Veterans General Hospital, 
      Taichung, Taiwan.
AD  - College of Human Science and Social Innovation, Hungkuang University, Taichung, 
      Taiwan.
AD  - Program in Translational Medicine, National Chung Hsing University, Taichung, 
      Taiwan.
AD  - Division of Clinical Research, Department of Medical Research, Taichung Veterans 
      General Hospital.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20220710
PL  - England
TA  - Expert Rev Clin Pharmacol
JT  - Expert review of clinical pharmacology
JID - 101278296
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Asthmatic Agents)
SB  - IM
MH  - Administration, Inhalation
MH  - Adrenal Cortex Hormones
MH  - *Anti-Asthmatic Agents/therapeutic use
MH  - *Asthma/drug therapy
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - *COVID-19 Drug Treatment
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - inhaled corticosteroids
EDAT- 2022/07/06 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/05 13:16
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/05 13:16 [entrez]
AID - 10.1080/17512433.2022.2094769 [doi]
PST - ppublish
SO  - Expert Rev Clin Pharmacol. 2022 May;15(5):593-600. doi: 
      10.1080/17512433.2022.2094769. Epub 2022 Jul 10.