PMID- 35787667
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220725
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jul 5
TI  - Sarcopenic obesity is associated with impaired physical function and mortality in 
      older patients with heart failure: insight from FRAGILE-HF.
PG  - 556
LID - 10.1186/s12877-022-03168-3 [doi]
LID - 556
AB  - BACKGROUND: The purpose of this study was to clarify the prevalence, association 
      with frailty and exercise capacity, and prognostic implication of sarcopenic 
      obesity in patients with heart failure. METHODS: The present study included 779 
      older adults hospitalized with heart failure (median age: 81 years; 57.4% men). 
      Sarcopenia was diagnosed based on the guidelines by the Asian Working Group for 
      Sarcopenia. Obesity was defined as the percentage of body fat mass (FM) obtained 
      by bioelectrical impedance analysis. The FM cut-off points for obesity were 38% 
      for women and 27% for men. The primary endpoint was 1-year all-cause death. We 
      assessed the associations of sarcopenic obesity occurrence with the short 
      physical performance battery (SPPB) score and 6-minute walk distance (6MWD). 
      RESULTS: The rates of sarcopenia and obesity were 19.3 and 26.2%, respectively. 
      The patients were classified into the following groups: 
      non-sarcopenia/non-obesity (58.5%), non-sarcopenia/obesity (22.2%), 
      sarcopenia/non-obesity (15.3%), and sarcopenia/obesity (4.0%). The 
      sarcopenia/obesity group had a lower SPPB score and shorter 6MWD, which was 
      independent of age and sex (coefficient, - 0.120; t-value, - 3.74; P < 0.001 and 
      coefficient, - 77.42; t-value, - 3.61; P < 0.001; respectively). Ninety-six 
      patients died during the 1-year follow-up period. In a Cox proportional hazard 
      analysis, sarcopenia and obesity together were an independent prognostic factor 
      even after adjusting for a coexisting prognostic factor 
      (non-sarcopenia/non-obesity vs. sarcopenia/obesity: hazard ratio, 2.48; 95% 
      confidence interval, 1.22-5.04; P = 0.012). CONCLUSION: Sarcopenic obesity is a 
      risk factor for all-cause death and low physical function in older adults with 
      heart failure. TRIAL REGISTRATION: University Hospital Information Network 
      (UMIN-CTR: UMIN000023929 ).
CI  - (c) 2022. The Author(s).
FAU - Saito, Hiroshi
AU  - Saito H
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
AD  - Department of Rehabilitation, Kameda Medical Center, Chiba, Japan.
FAU - Matsue, Yuya
AU  - Matsue Y
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. 
      yuya8950@gmail.com.
AD  - Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan. yuya8950@gmail.com.
FAU - Kamiya, Kentaro
AU  - Kamiya K
AD  - Department of Rehabilitation, School of Allied Health Sciences, Kitasato 
      University, Kanagawa, Japan.
FAU - Kagiyama, Nobuyuki
AU  - Kagiyama N
AD  - Department of Cardiology, The Sakakibara Heart Institute of Okayama, Okayama, 
      Japan.
AD  - Department of Digital Health and Telemedicine R&D, Juntendo University, Tokyo, 
      Japan.
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Faculty of 
      Medicine, Tokyo, Japan.
FAU - Maeda, Daichi
AU  - Maeda D
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
AD  - Department of Cardiology, Osaka Medical and Pharmaceutical University, Osaka, 
      Japan.
FAU - Endo, Yoshiko
AU  - Endo Y
AD  - Department of Rehabilitation, Kameda Medical Center, Chiba, Japan.
FAU - Ueno, Hidenao
AU  - Ueno H
AD  - Department of Rehabilitation, Kameda Medical Center, Chiba, Japan.
FAU - Yoshioka, Kenji
AU  - Yoshioka K
AD  - Department of Cardiology, Kameda Medical Center, Chiba, Japan.
FAU - Mizukami, Akira
AU  - Mizukami A
AD  - Department of Cardiology, Kameda Medical Center, Chiba, Japan.
FAU - Saito, Kazuya
AU  - Saito K
AD  - Department of Rehabilitation, The Sakakibara Heart Institute of Okayama, Okayama, 
      Japan.
FAU - Ogasahara, Yuki
AU  - Ogasahara Y
AD  - Department of Nursing, The Sakakibara Heart Institute of Okayama, Okayama, Japan.
FAU - Maekawa, Emi
AU  - Maekawa E
AD  - Department of Cardiovascular Medicine, Kitasato University School of Medicine, 
      Kanagawa, Japan.
FAU - Konishi, Masaaki
AU  - Konishi M
AD  - Division of Cardiology, Yokohama City University Medical Center, Kanagawa, Japan.
FAU - Kitai, Takeshi
AU  - Kitai T
AD  - Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, 
      Hyogo, Japan.
FAU - Iwata, Kentaro
AU  - Iwata K
AD  - Department of Rehabilitation, Kobe City Medical Center General Hospital, Hyogo, 
      Japan.
FAU - Jujo, Kentaro
AU  - Jujo K
AD  - Department of Cardiology, Nishiarai Heart Center Hospital, Tokyo, Japan.
FAU - Wada, Hiroshi
AU  - Wada H
AD  - Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical 
      University, Saitama, Japan.
FAU - Hiki, Masaru
AU  - Hiki M
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Dotare, Taishi
AU  - Dotare T
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Sunayama, Tsutomu
AU  - Sunayama T
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
FAU - Kasai, Takatoshi
AU  - Kasai T
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
AD  - Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Nagamatsu, Hirofumi
AU  - Nagamatsu H
AD  - Department of Cardiology, Tokai University School of Medicine, Tokyo, Japan.
FAU - Ozawa, Tetsuya
AU  - Ozawa T
AD  - Department of Rehabilitation, Odawara Municipal Hospital, Kanagawa, Japan.
FAU - Izawa, Katsuya
AU  - Izawa K
AD  - Department of Rehabilitation, Kasukabe Chuo General Hospital, Saitama, Japan.
FAU - Yamamoto, Shuhei
AU  - Yamamoto S
AD  - Department of Rehabilitation, Shinshu University Hospital, Nagano, Japan.
FAU - Aizawa, Naoki
AU  - Aizawa N
AD  - Department of Cardiovascular Medicine, Nephrology and Neurology, University of 
      Ryukyus, Okinawa, Japan.
FAU - Wakaume, Kazuki
AU  - Wakaume K
AD  - Department of Rehabilitation, Kitasato University Medical Center, Saitama, Japan.
FAU - Oka, Kazuhiro
AU  - Oka K
AD  - Department of Rehabilitation, Saitama Citizens Medical Center, Saitama, Japan.
FAU - Momomura, Shin-Ichi
AU  - Momomura SI
AD  - Saitama Citizens Medical Center, Saitama, Japan.
FAU - Minamino, Tohru
AU  - Minamino T
AD  - Department of Cardiovascular Biology and Medicine, Juntendo University Graduate 
      School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
AD  - Japan Agency for Medical Research and Development-Core Research for Evolutionary 
      Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research 
      and Development, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220705
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Heart Failure/complications/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Obesity/complications/diagnosis/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - *Sarcopenia/diagnosis/epidemiology
PMC - PMC9254413
OTO - NOTNLM
OT  - Heart failure
OT  - Mortality
OT  - Older adults
OT  - Physical function
OT  - Sarcopenic obesity
COIS- YM and TK are affiliated with a department endowed by Philips Respironics, 
      ResMed, Teijin Home Healthcare, and Fukuda Denshi. YM received an honorarium from 
      Otsuka Pharmaceutical Co. and Novartis Japan. NK reports grants from Philips, 
      grants from Asahi KASEI Corporation, Toho Holdings Co. Ltd., and Inter Reha Co. 
      Ltd. outside the submitted work. KK received research funding from Eiken Chemical 
      Co., Ltd. Other authors have nothing to declare.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/07 06:00
PMCR- 2022/07/05
CRDT- 2022/07/05 17:43
PHST- 2021/07/03 00:00 [received]
PHST- 2022/05/16 00:00 [accepted]
PHST- 2022/07/05 17:43 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/07/05 00:00 [pmc-release]
AID - 10.1186/s12877-022-03168-3 [pii]
AID - 3168 [pii]
AID - 10.1186/s12877-022-03168-3 [doi]
PST - epublish
SO  - BMC Geriatr. 2022 Jul 5;22(1):556. doi: 10.1186/s12877-022-03168-3.