PMID- 35787931
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220927
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 74
DP  - 2022 Oct
TI  - A case of successful desensitization using therapeutic plasma exchange in 
      high-risk HLA incompatible kidney transplantation.
PG  - 101656
LID - S0966-3274(22)00130-7 [pii]
LID - 10.1016/j.trim.2022.101656 [doi]
AB  - Advances in immune suppression therapies and desensitization have made possible 
      kidney transplantation regardless of HLA incompatibility. Single antigen bead 
      assay (SAB) is a semi-quantitative estimation of the amount of human leukocyte 
      antigen (HLA) antibodies present in the recipient plasma, and mean fluorescence 
      intensity (MFI) generated gives this rough estimation of the antibodies present 
      in the recipient. Here we present a case of successful kidney transplantation in 
      a patient who expressed DSA with high MFI. A 33-yr-old male, diagnosed with 
      chronic kidney disease (CKD) on regular maintenance hemodialysis, opted for 
      second kidney transplant with his sibling as prospective donor and was referred 
      to the department of Transplant Immunology for histocompatibility testing. 
      Patient had HLA incompatibility with multiple DSA identified by SAB. Patient 
      undergone 20 sessions of plasma exchange till discharge and finally till 6 months 
      graft was functioning well. The authors thus conclude that the option of a 
      high-risk HLA incompatible kidney transplant can be offered to recipients with 
      high MFI DSA, who wish to undergo transplantation for end stage renal disease.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Pandey, Prashant
AU  - Pandey P
AD  - Transfusion Medicine & Blood Centre, Jaypee Hospital, Noida, Delhi NCR, India. 
      Electronic address: pkpandey2007@gmail.com.
FAU - Kumari, Supriya
AU  - Kumari S
AD  - Transfusion Medicine & Blood Centre, Jaypee Hospital, Noida, Delhi NCR, India.
FAU - Mandal, Saikat
AU  - Mandal S
AD  - Transfusion Medicine & Blood Centre, Jaypee Hospital, Noida, Delhi NCR, India.
FAU - Sinha, Vijay Kumar
AU  - Sinha VK
AD  - Nephrology & Renal Transplant, Jaypee Hospital, Noida, Delhi NCR, India. 
      Electronic address: vijay.sinha@jalindia.co.in.
FAU - Devra, Amit Kumar
AU  - Devra AK
AD  - Urology & Renal Transplant, Jaypee Hospital, Noida, Delhi NCR, India. Electronic 
      address: Amit.devra@jalindia.com.
FAU - Singh, Ravi Kumar
AU  - Singh RK
AD  - Nephrology & Renal Transplant, Jaypee Hospital, Noida, Delhi NCR, India.
FAU - Kumar, Praveen
AU  - Kumar P
AD  - Transfusion Medicine & Blood Centre, Jaypee Hospital, Noida, Delhi NCR, India. 
      Electronic address: praveen1.kumar@jalindia.co.in.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220702
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Graft Rejection/therapy
MH  - Graft Survival
MH  - HLA Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Plasma Exchange
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Desensitization transplant
OT  - HLA incompatible kidney transplant
OT  - Kidney transplant
EDAT- 2022/07/06 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/07/05 17:55
PHST- 2022/04/05 00:00 [received]
PHST- 2022/06/03 00:00 [revised]
PHST- 2022/06/22 00:00 [accepted]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/07/05 17:55 [entrez]
AID - S0966-3274(22)00130-7 [pii]
AID - 10.1016/j.trim.2022.101656 [doi]
PST - ppublish
SO  - Transpl Immunol. 2022 Oct;74:101656. doi: 10.1016/j.trim.2022.101656. Epub 2022 
      Jul 2.