PMID- 35789592
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220716
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2022
DP  - 2022
TI  - Long-Term Metabolic Outcomes after Gestational Diabetes Mellitus (GDM): Results 
      from the Odense GDM Follow-Up Study (OGFUS).
PG  - 4900209
LID - 10.1155/2022/4900209 [doi]
LID - 4900209
AB  - AIMS: To compare metabolic profiles and the long-term risk of metabolic 
      dysfunction between women with previous gestational diabetes mellitus (pGDM) and 
      women without pGDM (non-GDM) matched on age, prepregnancy body mass index (BMI), 
      and parity. METHODS: In total, 128 women with pGDM (median follow-up: 7.8 years) 
      and 70 non-GDM controls (median follow-up: 10.0 years) completed a 2 h oral 
      glucose tolerance test (OGTT) with assessment of glucose, C-peptide, insulin, and 
      other metabolic measures. Additionally, anthropometrics, fat mass, and blood 
      pressure were assessed and indices of insulin sensitivity and beta cell function 
      were calculated. RESULTS: The prevalence of type 2 diabetes mellitus (T2DM) was 
      significantly higher in the pGDM group compared to the non-GDM group (26% vs. 
      0%). For women with pGDM, the prevalence of prediabetes (38%) and the metabolic 
      syndrome (MetS) (59%) were approximately 3-fold higher than in non-GDM women (p's 
      < 0.001). Both insulin sensitivity and beta cell function were significantly 
      reduced in pGDM women compared to non-GDM women. CONCLUSION: Despite similar BMI, 
      women with pGDM had a substantially higher risk of developing T2DM, prediabetes, 
      and the MetS compared to controls. Both beta cell dysfunction and reduced insulin 
      sensitivity seem to contribute to this increased risk.
CI  - Copyright (c) 2022 Kristine Hovde Jacobsen et al.
FAU - Jacobsen, Kristine Hovde
AU  - Jacobsen KH
AUID- ORCID: 0000-0002-3808-011X
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
FAU - Aalders, Jori
AU  - Aalders J
AUID- ORCID: 0000-0002-7207-8304
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
AD  - Department of Psychology, University of Southern Denmark, Odense, Denmark.
FAU - Solling, Katrine
AU  - Solling K
AUID- ORCID: 0000-0002-3695-7344
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
FAU - Andersen, Marianne Skovsager
AU  - Andersen MS
AUID- ORCID: 0000-0002-4603-9504
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
FAU - Snogdal, Lena Sonder
AU  - Snogdal LS
AUID- ORCID: 0000-0001-8999-4651
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
FAU - Christensen, Maria Hornstrup
AU  - Christensen MH
AUID- ORCID: 0000-0002-4985-4491
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
AD  - Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
AD  - Department of Gynecology and Obstetrics, Odense University Hospital, Odense, 
      Denmark.
FAU - Vinter, Christina Anne
AU  - Vinter CA
AUID- ORCID: 0000-0001-5084-6053
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
AD  - Department of Gynecology and Obstetrics, Odense University Hospital, Odense, 
      Denmark.
FAU - Hojlund, Kurt
AU  - Hojlund K
AUID- ORCID: 0000-0002-0891-4224
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
FAU - Jensen, Dorte Moller
AU  - Jensen DM
AUID- ORCID: 0000-0002-3298-9824
AD  - Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
AD  - Department of Endocrinology, Odense University Hospital, Odense, Denmark.
AD  - Department of Gynecology and Obstetrics, Odense University Hospital, Odense, 
      Denmark.
LA  - eng
PT  - Journal Article
DEP - 20220625
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Insulin)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Diabetes, Gestational
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin/therapeutic use
MH  - *Insulin Resistance
MH  - *Metabolic Syndrome/epidemiology
MH  - *Prediabetic State/epidemiology
MH  - Pregnancy
PMC - PMC9250439
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/07 06:00
PMCR- 2022/06/25
CRDT- 2022/07/05 19:47
PHST- 2021/12/23 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/07/05 19:47 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/06/25 00:00 [pmc-release]
AID - 10.1155/2022/4900209 [doi]
PST - epublish
SO  - J Diabetes Res. 2022 Jun 25;2022:4900209. doi: 10.1155/2022/4900209. eCollection 
      2022.