PMID- 35790366
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20220706
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 76
IP  - 3
DP  - 2022 Jun
TI  - Rhabdomyolysis with Multiple Electrolyte Imbalances under Proton Pump Inhibitor 
      Treatment after Total Thyroidectomy.
PG  - 339-342
LID - 10.18926/AMO/63745 [doi]
AB  - A 90-year-old man presented with muscle weakness, difficulty concentrating, and 
      dysphagia. About eighteen months prior to presentation, lansoprazole had been 
      initiated to prevent stress ulcers; he also had a history of total thyroidectomy 
      due to papillary thyroid cancer ten years prior. Laboratory findings were as 
      follows: K 2.4 mEq/L, Ca 3.7 mg/dL, Mg 1.3 mg/dL, CK 5386 U/L, and intact PTH 
      (iPTH) 14 pg/mL. Rhabdomyolysis with multiple electrolyte imbalances under proton 
      pump inhibitor (PPI) treatment was diagnosed. We initiated intravenous hydration 
      and electrolyte supplementation with discontinuation of PPI. After discontinuing 
      PPI, the patient's serum magnesium, potassium, and calcium levels normalised with 
      oral vitamin D and calcium supplementation. PPIs can cause hypocalcaemia and 
      hypokalaemia via hypomagnesemia; hypocalcaemia is also a common postoperative 
      complication of thyroidectomy. Careful monitoring of electrolyte levels is 
      required in patients with long-term PPI treatment, especially in 
      post-thyroidectomy cases.
FAU - Yano, Akihiko
AU  - Yano A
AD  - Department of General Medicine, Kochi Health Sciences Center.
FAU - Sada, Ken-Ei
AU  - Sada KE
AD  - Department of General Medicine, Kochi Health Sciences Center.
AD  - Department of Clinical Epidemiology, Kochi Medical School, Kochi University.
AD  - Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama 
      University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
FAU - Sawada, Tsutomu
AU  - Sawada T
AD  - Department of General Medicine, Kochi Health Sciences Center.
FAU - Ito, Hideki
AU  - Ito H
AD  - Department of General Medicine, Kochi Health Sciences Center.
FAU - Yano, Hiroko
AU  - Yano H
AD  - Department of General Medicine, Kochi Health Sciences Center.
FAU - Ikeda, Tatsuya
AU  - Ikeda T
AD  - Department of General Medicine, Kochi Health Sciences Center.
LA  - eng
PT  - Case Reports
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (Proton Pump Inhibitors)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged, 80 and over
MH  - Calcium
MH  - Humans
MH  - *Hypocalcemia/drug therapy/etiology
MH  - Male
MH  - Proton Pump Inhibitors/therapeutic use
MH  - *Rhabdomyolysis
MH  - *Thyroid Neoplasms
MH  - Thyroidectomy/adverse effects
OTO - NOTNLM
OT  - hypocalcaemia
OT  - hypomagnesemia
OT  - proton pump inhibitors
OT  - rhabdomyolysis
OT  - thyroidectomy
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2022/07/06 06:00
MHDA- 2022/07/07 06:00
CRDT- 2022/07/05 21:18
PHST- 2022/07/05 21:18 [entrez]
PHST- 2022/07/06 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
AID - 10.18926/AMO/63745 [doi]
PST - ppublish
SO  - Acta Med Okayama. 2022 Jun;76(3):339-342. doi: 10.18926/AMO/63745.