PMID- 35791517
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
DP  - 2022 Jul 6
TI  - Association between hyperhomocysteinaemia and the risk of all-cause and 
      cause-specific mortality among adults in the USA.
PG  - 1-12
LID - 10.1017/S0007114522002082 [doi]
AB  - Hyperhomocysteinaemia (HHcy) is associated with all-cause mortality in some 
      disease states. However, the correlation between HHcy and the risk of mortality 
      in the general population has rarely been researched. We aimed to evaluate the 
      association between HHcy and all-cause and cause-specific mortality among adults 
      in the USA. This study analysed data from the National Health and Nutrition 
      Examination Survey database (1999-2002 survey cycle). A multivariable Cox 
      regression model was built to evaluate the correlation between HHcy and all-cause 
      and cause-specific mortality. Smooth curve fitting was used to analyse their 
      dose-dependent relationship. A total of 8442 adults aged 18-70 years were 
      included in this study. After a median follow-up period of 14.7 years, 1007 (11.9 
      %) deaths occurred including 197 CVD-related deaths, 255 cancer-related deaths 
      and fifty-eight respiratory disease deaths. The participants with HHcy had a 93 % 
      increased risk of all-cause mortality (hazard ratio (HR) 1.93; 95 % CI (1.48, 
      2.51)), 160 % increased risk of CVD mortality (HR 2.60; 95 % CI (1.52, 4.45)) and 
      82 % increased risk of cancer mortality (HR 1.82; 95 % CI (1.03, 3.21)) compared 
      with those without HHcy. For unmeasured confounding, E-value analysis proved to 
      be robust. In conclusion, HHcy was associated with high risk of all-cause and 
      cause-specific (CVD, cancer) mortality among adults aged below 70 years.
FAU - Zhao, Wenyan
AU  - Zhao W
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Lin, Yan
AU  - Lin Y
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - He, Huibo
AU  - He H
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Ma, Honglei
AU  - Ma H
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Yang, Wei
AU  - Yang W
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Hu, Qian
AU  - Hu Q
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Chen, Xi
AU  - Chen X
AD  - Center for General Practice Medicine, Department of General Practice Medicine, 
      Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou 
      Medical College), Hangzhou, Zhejiang, People's Republic of China.
FAU - Gao, Faliang
AU  - Gao F
AUID- ORCID: 0000-0002-8170-2156
AD  - Center for Rehabilitation Medicine, Department of Neurosurgery, Zhejiang 
      Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical 
      College), Hangzhou, Zhejiang, People's Republic of China.
AD  - Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220706
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
SB  - IM
OTO - NOTNLM
OT  - Adults
OT  - Hyperhomocysteinaemia
OT  - Mortality
OT  - National Health and Nutrition Examination Survey
EDAT- 2022/07/07 06:00
MHDA- 2022/07/07 06:00
CRDT- 2022/07/06 02:52
PHST- 2022/07/07 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/07/06 02:52 [entrez]
AID - S0007114522002082 [pii]
AID - 10.1017/S0007114522002082 [doi]
PST - aheadofprint
SO  - Br J Nutr. 2022 Jul 6:1-12. doi: 10.1017/S0007114522002082.