PMID- 35791959
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230412
IS  - 1939-165X (Electronic)
IS  - 0275-6382 (Print)
IS  - 0275-6382 (Linking)
VI  - 51
IP  - 4
DP  - 2022 Dec
TI  - Establishment of a reference interval for urinary albumin-to-creatinine ratio in 
      dogs.
PG  - 585-590
LID - 10.1111/vcp.13149 [doi]
AB  - BACKGROUND: Albuminuria is an important marker of renal damage and can precede 
      proteinuria; thus, it can be a useful analyte in the early diagnosis of kidney 
      diseases. Albuminuria has also been found in dogs with hypertension, 
      inflammatory, infectious, and neoplastic diseases. OBJECTIVES: The aim of this 
      study was to establish a reference interval (RI) for albuminuria in dogs. 
      METHODS: One hundred sixty-four clinically healthy dogs were enrolled in the 
      study. Urinary albumin was determined by the immunoturbidimetric method, and 
      albumin excretion was expressed as the urinary albumin-to-creatinine (UAC) ratio. 
      The RI for UAC was established. RESULTS: After exclusions, 124 dogs from 32 
      breeds remained. The median UAC of the study population was 3.0 mg/g (range: 
      0-48). The RI was defined as 0-19 mg/g (with a 90% CI for the upper limit of 
      13-28 mg/g). No significant difference was found between male and female dogs or 
      between different age and body weight groups. The results of Sighthounds (n = 30) 
      and Beagle dogs (n = 23) did not differ from the other breeds. CONCLUSION: The 
      canine RI of UAC is similar but somewhat narrower than the human RI.
CI  - (c) 2022 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals 
      LLC on behalf of American Society for Veterinary Clinical Pathology.
FAU - Falus, Fruzsina Anna
AU  - Falus FA
AUID- ORCID: 0000-0003-3101-6622
AD  - Department of Internal Medicine, University of Veterinary Medicine, Budapest, 
      Hungary.
FAU - Vizi, Zsuzsanna
AU  - Vizi Z
AUID- ORCID: 0000-0001-9109-7482
AD  - Department of Internal Medicine, University of Veterinary Medicine, Budapest, 
      Hungary.
FAU - Szabo, Korinna Eva
AU  - Szabo KE
AD  - Department of Internal Medicine, University of Veterinary Medicine, Budapest, 
      Hungary.
FAU - Muller, Linda
AU  - Muller L
AD  - Department of Obstetrics and Food Animal Medicine Clinic, University of 
      Veterinary Medicine, Budapest, Hungary.
FAU - Reiczigel, Jeno
AU  - Reiczigel J
AD  - Department of Biomathematics and Informatics, University of Veterinary Medicine, 
      Budapest, Hungary.
FAU - Balogh, Nandor
AU  - Balogh N
AD  - Praxislab Kft, Budapest, Hungary.
FAU - Manczur, Ferenc
AU  - Manczur F
AD  - Department of Internal Medicine, University of Veterinary Medicine, Budapest, 
      Hungary.
LA  - eng
GR  - 11475-4/2016/FEKUT/Hungarian Ministry of Human Resources/
PT  - Journal Article
DEP - 20220706
PL  - United States
TA  - Vet Clin Pathol
JT  - Veterinary clinical pathology
JID - 9880575
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Albumins)
SB  - IM
MH  - Dogs
MH  - Animals
MH  - Humans
MH  - Male
MH  - Female
MH  - *Albuminuria/diagnosis/veterinary/epidemiology
MH  - Creatinine/urine
MH  - Urinalysis/veterinary
MH  - Proteinuria/veterinary
MH  - Albumins
MH  - *Dog Diseases/diagnosis/urine
PMC - PMC10084387
OTO - NOTNLM
OT  - albuminuria
OT  - canine
OT  - normal value
OT  - proteinuria
EDAT- 2022/07/07 06:00
MHDA- 2022/12/03 06:00
PMCR- 2023/04/10
CRDT- 2022/07/06 06:13
PHST- 2022/03/21 00:00 [revised]
PHST- 2021/11/10 00:00 [received]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/07/07 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/07/06 06:13 [entrez]
PHST- 2023/04/10 00:00 [pmc-release]
AID - VCP13149 [pii]
AID - 10.1111/vcp.13149 [doi]
PST - ppublish
SO  - Vet Clin Pathol. 2022 Dec;51(4):585-590. doi: 10.1111/vcp.13149. Epub 2022 Jul 6.