PMID- 35793044 OWN - NLM STAT- MEDLINE DCOM- 20230321 LR - 20230321 IS - 1559-0720 (Electronic) IS - 0163-4984 (Linking) VI - 201 IP - 5 DP - 2023 May TI - Sex-Specific Associations of Urinary Metals with Renal Function: a Cross-sectional Study in China. PG - 2240-2249 LID - 10.1007/s12011-022-03349-6 [doi] AB - BACKGROUND: Extensive studies have revealed the link between heavy metals and CKD. Compared to single meta-elements, mixture of metals reflect real-life metals exposure scenarios and are of interest. However, the mechanism of action of metal mixture on renal function is unclear. METHODS: This study aimed to explore the potential relationship between urinary arsenic (As), cadmium (Cd), lead (Pb), manganese (Mn), and chromium (Cr) contents with estimated glomerular filtration rate (eGFR) levels in 2775 participants. The levels of metals in urine were determined by inductively coupled plasma-mass spectrometry. We used linear regression models and the Bayesian kernel machine regression (BKMR) to evaluate the association between metals and eGFR levels. RESULTS: In linear regression analysis, urinary As (beta = 2.723, 95%CI: 0.29, 5.157) and Pb (beta = 3.081, 95%CI: 1.725, 4.438) were positively associated with eGFR in the total population. In the BKMR model, a mixture of the five metals had a positive joint effect on eGFR levels, while Pb (PIP = 0.996) contributed the most to eGFR levels. Pb was positively associated with eGFR levels in the total participants and women. As was positively correlated with eGFR levels in women. Pb and eGFR levels were positively correlated when the other metals were set at 25th, 50th, and 75th percentiles. CONCLUSIONS: To the best of our knowledge, all five metals mixed exposure was positively associated with eGFR. Pb showed more important effects than the other four metals in the mixture, especially in women. CI - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Lin, Yinxia AU - Lin Y AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Cai, Jiansheng AU - Cai J AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. AD - Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. FAU - Liu, Qiumei AU - Liu Q AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Mo, Xiaoting AU - Mo X AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Xu, Min AU - Xu M AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Zhang, Junling AU - Zhang J AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Liu, Shuzhen AU - Liu S AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Wei, Chunmei AU - Wei C AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Wei, Yanfei AU - Wei Y AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Huang, Shenxiang AU - Huang S AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Mai, Tingyu AU - Mai T AD - School of Public Health, Guilin Medical University, 20 Lequn Road, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. FAU - Tan, Dechan AU - Tan D AD - School of Public Health, Guilin Medical University, 20 Lequn Road, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. FAU - Lu, Huaxiang AU - Lu H AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. FAU - Luo, Tingyu AU - Luo T AD - School of Public Health, Guilin Medical University, 20 Lequn Road, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. FAU - Gou, Ruoyu AU - Gou R AD - School of Public Health, Guilin Medical University, 20 Lequn Road, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. FAU - Zhang, Zhiyong AU - Zhang Z AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. rpazz@163.com. AD - School of Public Health, Guilin Medical University, 20 Lequn Road, Guangxi Zhuang Autonomous Region, Guilin, 541004, China. rpazz@163.com. AD - Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin, China. rpazz@163.com. FAU - Qin, Jian AU - Qin J AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China. qinjian@gxmu.edu.cn. LA - eng GR - No. 81760577/National Natural Science Foundation of China/ GR - No. AD17129003/Scientific Research and Technology Development Program of Guangxi/ GR - No. GKAA22399/Major Science and Technology Projects in Guangxi/ GR - No. 2019GXNSFGA245002/Guangxi Natural Science Foundation for Innovation Research Team/ PT - Journal Article DEP - 20220706 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 2P299V784P (Lead) RN - 0 (Metals, Heavy) SB - IM MH - Male MH - Humans MH - Female MH - Cross-Sectional Studies MH - Bayes Theorem MH - *Lead MH - *Metals, Heavy/urine MH - Kidney/physiology MH - China OTO - NOTNLM OT - Bayesian regression model OT - Estimated glomerular filtration rate OT - Urinary metal EDAT- 2022/07/07 06:00 MHDA- 2023/03/22 06:00 CRDT- 2022/07/06 11:18 PHST- 2022/05/05 00:00 [received] PHST- 2022/06/28 00:00 [accepted] PHST- 2022/07/07 06:00 [pubmed] PHST- 2023/03/22 06:00 [medline] PHST- 2022/07/06 11:18 [entrez] AID - 10.1007/s12011-022-03349-6 [pii] AID - 10.1007/s12011-022-03349-6 [doi] PST - ppublish SO - Biol Trace Elem Res. 2023 May;201(5):2240-2249. doi: 10.1007/s12011-022-03349-6. Epub 2022 Jul 6.