PMID- 35793317
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220722
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 7
DP  - 2022
TI  - Daily physical activity is negatively associated with thyroid hormone levels, 
      inflammation, and immune system markers among men and women in the NHANES 
      dataset.
PG  - e0270221
LID - 10.1371/journal.pone.0270221 [doi]
LID - e0270221
AB  - The acute effects of exercise on metabolic energy expenditure and inflammation 
      are well studied, but the long-term effects of regular daily physical activity on 
      metabolic and endocrine effects are less clear. Further, prior studies 
      investigating the impact of daily physical activity in large cohorts have 
      generally relied on self-reported activity. Here, we used the U.S. National 
      Health and Nutrition Examination Survey (NHANES) to investigate the relationship 
      between daily physical activity and both thyroid and immune activity. Daily 
      physical activity was assessed through accelerometry or accelerometry-validated 
      survey responses. Thyroid activity was assessed from circulating levels of 
      thyroid stimulating hormone (TSH) and thyroxine (T4). Immune function was 
      assessed from circulating cytokines (C-reactive protein [CRP], immunoglobulin E 
      [IgE], fibrinogen) and blood cell counts. In general linear models including body 
      mass index, age, gender, activity and TSH as factors, active adults had a lower 
      levels of T4 and reduced slope of the TSH:T4 relationship. Similarly, greater 
      physical activity was associated with lower CRP and fibrinogen levels (but not 
      IgE) and lower white blood cell, basophil, monocyte, neutrophil, and eosinophil 
      (but not lymphocyte) counts. Daily physical activity was also associated with 
      lower prevalence of clinically elevated CRP, WBC, and lymphocytes in a 
      dose-response manner. These results underscore the long-term impact of daily 
      physical activity on both systemic metabolic activity (thyroid) and on specific 
      physiological tasks (immune). The regulatory effects of physical activity on 
      other bodily systems are clinically relevant and should be incorporated into 
      public health strategies promoting exercise.
FAU - Klasson, Christopher L
AU  - Klasson CL
AUID- ORCID: 0000-0003-1250-150X
AD  - Trinity College, Duke University, Durham, North Carolina, United States of 
      America.
FAU - Sadhir, Srishti
AU  - Sadhir S
AUID- ORCID: 0000-0002-3689-5892
AD  - Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, 
      United States of America.
FAU - Pontzer, Herman
AU  - Pontzer H
AD  - Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, 
      United States of America.
AD  - Duke Global Health Institute, Duke University, Durham, North Carolina, United 
      States of America.
LA  - eng
PT  - Journal Article
DEP - 20220706
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Thyroid Hormones)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - C-Reactive Protein
MH  - Exercise
MH  - Female
MH  - Fibrinogen
MH  - Humans
MH  - Inflammation
MH  - Leukocytes
MH  - Male
MH  - Nutrition Surveys
MH  - *Thyroid Gland
MH  - *Thyroid Hormones
MH  - Thyrotropin
PMC - PMC9258892
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/07/07 06:00
MHDA- 2022/07/09 06:00
PMCR- 2022/07/06
CRDT- 2022/07/06 13:34
PHST- 2022/02/08 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/07/06 13:34 [entrez]
PHST- 2022/07/07 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2022/07/06 00:00 [pmc-release]
AID - PONE-D-22-03932 [pii]
AID - 10.1371/journal.pone.0270221 [doi]
PST - epublish
SO  - PLoS One. 2022 Jul 6;17(7):e0270221. doi: 10.1371/journal.pone.0270221. 
      eCollection 2022.