PMID- 35795369
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Predictive Value of Non-high-Density Lipoprotein Cholesterol and 
      Neutrophil-Lymphocyte Ratio for Coronary Artery Vulnerable Plaques in Type 2 
      Diabetes Mellitus.
PG  - 927768
LID - 10.3389/fcvm.2022.927768 [doi]
LID - 927768
AB  - BACKGROUND: Patients with diabetes have an increased risk of developing 
      vulnerable plaques (VPs), in which dyslipidemia and chronic inflammation play 
      important roles. Non-high-density lipoprotein cholesterol (non-HDL-C) and 
      neutrophil-lymphocyte ratio (NLR) have emerged as potential markers of both 
      coronary artery VPs and cardiovascular prognosis. This study aimed to investigate 
      the predictive value of non-HDL-C and NLR for coronary artery VPs in patients 
      with type 2 diabetes mellitus (T2DM). METHODS: We retrospectively enrolled 204 
      patients with T2DM who underwent coronary computed tomography angiography between 
      January 2018 and June 2020. Clinical data including age, sex, hypertension, 
      smoking, total cholesterol, low-density lipoprotein cholesterol, HDL-C, 
      triglyceride, non-HDL-C, glycated hemoglobin, neutrophil count, lymphocyte count, 
      NLR, and platelet count were analyzed. Multivariate logistic regression was used 
      to estimate the association between non-HDL-C, NLR, and coronary artery VPs. 
      Receiver operating curve analysis was performed to evaluate the value of 
      non-HDL-C, NLR, and their combination in predicting coronary artery VPs. RESULTS: 
      In our study, 67 patients (32.84%) were diagnosed with VPs, 75 (36.77%) with 
      non-VP, and 62 (30.39%) with no plaque. Non-HDL-C and NLR were independent risk 
      factors for coronary artery VPs in patients with T2DM. The areas under the ROC 
      curve of non-HDL-C, NLR, and their combination were 0.748 [95% confidence 
      interval (CI): 0.676-0.818], 0.729 (95% CI: 0.650-0.800), and 0.825 (95% CI: 
      0.757-0.887), respectively. CONCLUSION: Either non-HDL-C or NLR could be used as 
      a predictor of coronary artery VPs in patients with T2DM, but the predictive 
      efficiency and sensitivity of their combination would be better.
CI  - Copyright (c) 2022 Huang, Yang, Zhao, Chen, Pan, Lai, Ouyang, Deng, Du, Li, Hu, Guo 
      and Liu.
FAU - Huang, Xiyi
AU  - Huang X
AD  - Department of Clinical Laboratory, The Affiliated Shunde Hospital of Guangzhou 
      Medical University, Foshan, China.
FAU - Yang, Shaomin
AU  - Yang S
AD  - Department of Radiology, The Affiliated Shunde Hospital of Guangzhou Medical 
      University, Foshan, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AD  - Department of Cardiovascular Medicine, The Affiliated Shunde Hospital of 
      Guangzhou Medical University, Foshan, China.
FAU - Chen, Xinjie
AU  - Chen X
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Pan, Jialing
AU  - Pan J
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Lai, Shaofen
AU  - Lai S
AD  - Department of Clinical Laboratory, The Affiliated Shunde Hospital of Guangzhou 
      Medical University, Foshan, China.
FAU - Ouyang, Fusheng
AU  - Ouyang F
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Deng, Lingda
AU  - Deng L
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Du, Yongxing
AU  - Du Y
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Li, Xiaohong
AU  - Li X
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Hu, Qiugen
AU  - Hu Q
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Guo, Baoliang
AU  - Guo B
AD  - Department of Radiology, Shunde Hospital, Southern Medical University (The First 
      People's Hospital of Shunde, Foshan), Foshan, China.
FAU - Liu, Jiemei
AU  - Liu J
AD  - Department of Rehabilitation Medicine, Shunde Hospital, Southern Medical 
      University (The First People's Hospital of Shunde, Foshan), Foshan, China.
LA  - eng
PT  - Journal Article
DEP - 20220620
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9251121
OTO - NOTNLM
OT  - coronary computed tomography angiography
OT  - coronary heart disease
OT  - neutrophil-lymphocyte ratio
OT  - non-high-density lipoprotein cholesterol
OT  - type 2 diabetes mellitus
OT  - vulnerable plaque
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/08 06:00
MHDA- 2022/07/08 06:01
PMCR- 2022/06/20
CRDT- 2022/07/07 02:27
PHST- 2022/04/25 00:00 [received]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/07/07 02:27 [entrez]
PHST- 2022/07/08 06:00 [pubmed]
PHST- 2022/07/08 06:01 [medline]
PHST- 2022/06/20 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.927768 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Jun 20;9:927768. doi: 10.3389/fcvm.2022.927768. 
      eCollection 2022.