PMID- 35795932
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220718
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 32
IP  - 7
DP  - 2022 Jul
TI  - TNF-alpha (G308A) Polymorphism and Vascular Parkinson Complicated with Pulmonary 
      Infection.
PG  - 860-863
LID - 10.29271/jcpsp.2022.07.860 [doi]
AB  - OBJECTIVE: To analyse relationship between tumour necrosis factor-alpha (TNF-alpha) 
      (G308A) polymorphism and Vascular Parkinson (VP) complicated with pulmonary 
      infection. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Zhuji 
      people's Hospital, China, from February 2017 to April 2021. METHODOLOGY: Eighty 
      five patients with VP complicated with pulmonary infection were included in the 
      observation group. Eighty five patients with VP were included in the comparison 
      group. Genotypic analysis of TNF-alpha (G308A) and serum TNF-alpha were detected. 
      RESULTS: TNF-alpha (G308A) polymorphism in both the observation group and control 
      group conformed to the genetic balance rule by the Hardy-Weinberg test. The 
      frequency of each gene satisfied the genetic balance (p=0.175, and p=0.184, 
      respectively). Genotype distribution and alleles of TNF-alpha (G308A) between the 
      observation group and the control group were different (both p <0.001). Compared 
      with control group, serum TNF-alpha level in the observation group was higher (p 
      <0.001). In the observation group, serum TNF-alpha level in cases with GA+AA genotype 
      (carrying A allele) was higher than that in cases with GG genotype (non A allele) 
      (p <0.001). CONCLUSION: TNF-alpha (G308A) polymorphism is associated with VP 
      complicated with pulmonary infection. VP Patients with TNF-alpha (G308A) AA genotype 
      and an allele may have a high risk of pulmonary infection. KEY WORDS: Tumor 
      necrosis factor-alpha (TNF-alpha), Polymorphism, Vascular Parkinson (VP), Pulmonary 
      infection.
FAU - Sun, Xiaoyun
AU  - Sun X
AD  - Department of Neurology, Zhuji People's Hospital, Zhejiang Province, China.
FAU - He, Yuping
AU  - He Y
AD  - Department of Neurology, Zhuji People's Hospital, Zhejiang Province, China.
FAU - Shen, Zhuoping
AU  - Shen Z
AD  - Department of General Practice, the Fourth People's Hospital of Zhuji City, 
      Zhejiang Province, China.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Neurology, Zhuji Hospital of Traditional Chinese Medicine, Zhejiang 
      Province, China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - *Parkinson Disease/complications/genetics
MH  - Polymorphism, Genetic
MH  - *Tumor Necrosis Factor-alpha/genetics
EDAT- 2022/07/08 06:00
MHDA- 2022/07/09 06:00
CRDT- 2022/07/07 02:53
PHST- 2021/09/08 00:00 [received]
PHST- 2021/11/24 00:00 [accepted]
PHST- 2022/07/07 02:53 [entrez]
PHST- 2022/07/08 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
AID - 040579197 [pii]
AID - 10.29271/jcpsp.2022.07.860 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2022 Jul;32(7):860-863. doi: 
      10.29271/jcpsp.2022.07.860.