PMID- 35796184
OWN - NLM
STAT- MEDLINE
DCOM- 20221115
LR  - 20231202
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Print)
IS  - 0926-9959 (Linking)
VI  - 36
IP  - 12
DP  - 2022 Dec
TI  - Genome-wide association study of dermatophytosis in the UK Biobank cohort.
PG  - 2482-2487
LID - 10.1111/jdv.18413 [doi]
AB  - BACKGROUND: Analyses of the hereditary propensity to dermatophytosis have 
      revealed several proven genetic relationships. They include CARD9 deficiency, 
      HLA-DR4 and HLA-DR8 type and genes encoding interleukin-22, defensin 2 and 4, and 
      genetic defects in dectin-1, which increased the prevalence of dermatophytosis in 
      families and were involved in the inheritance of susceptibility in their members. 
      METHODS: To further investigate the genetic basis of dermatophytosis, we 
      performed a genome-wide association study (GWAS) of the UK Biobank cohort. To 
      identify cases of dermatophytosis, we used ICD10 code B35, which covers Tinea 
      barbae, Tinea capitis, Tinea unguium, Tinea manuum, Tinea pedis, Tinea corporis, 
      Tinea imbricata, Tinea cruris, other dermatophytoses and dermatophytosis, 
      unspecified. Data processing was performed on Minerva, a Linux mainframe with 
      Centos 7.6, at the Icahn School of Medicine at Mount Sinai. We used PLINK, a 
      whole-genome association analysis toolset, to analyse the UKB chromosome files 
      and the UK Biobank Data Parser (ukbb parser), a python-based package that allows 
      easy interfacing with the large UK Biobank dataset. We used LocusZoom for the 
      Manhattan and q-q plots. Other statistical analyses were done with R and SPSS 25. 
      RESULTS: Genome-wide association study (GWAS) and meta-analysis association 
      statistics highlighted one susceptibility locus, Tubulointerstitial Nephritis 
      Antigen (TINAG), with genome-wide significance for dermatophytosis. The top SNP 
      was rs16885197, a missense variant within TINAG, position chr6:54308557, alleles 
      A > G, minor allele frequency (MAF) 0.014. Multivariate logistic regression 
      indicated that the minor G allele increased odds ratio of dermatophytosis by 7.8. 
      Carrying two G alleles raised dermatophytosis odds ratio by a factor of 14. 
      CONCLUSION: More research into genetic and other predisposing factors for 
      dermatophytosis is critical because of the implications for prophylaxis and 
      therapy. It might be possible to prevent infection and recurrence by identifying 
      people who are vulnerable to chronic dermatophytosis. Identifying high-risk 
      families would enable their members to be educated about the dangers of fungal 
      diseases. New therapeutic techniques to target altered hormonal and immune 
      response pathways might be created. TINAG is a prospective target that should be 
      investigated, based on the findings of this article.
CI  - (c) 2022 European Academy of Dermatology and Venereology.
FAU - Lehrer, S
AU  - Lehrer S
AUID- ORCID: 0000-0002-4850-094X
AD  - Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
FAU - Rheinstein, P H
AU  - Rheinstein PH
AD  - Severn Health Solutions, Severna Park, MA, USA.
LA  - eng
GR  - S10 OD018522/OD/NIH HHS/United States
GR  - S10 OD026880/OD/NIH HHS/United States
GR  - S10OD026880/NH/NIH HHS/United States
GR  - S10OD018522/NH/NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220713
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
SB  - IM
MH  - Humans
MH  - Genome-Wide Association Study
MH  - Biological Specimen Banks
MH  - *Tinea/epidemiology/genetics
MH  - *Tinea Capitis
MH  - United Kingdom/epidemiology
PMC - PMC9669130
MID - NIHMS1822247
COIS- Conflicts of interest: none
EDAT- 2022/07/08 06:00
MHDA- 2022/11/16 06:00
PMCR- 2023/12/01
CRDT- 2022/07/07 04:43
PHST- 2021/11/17 00:00 [received]
PHST- 2022/05/18 00:00 [accepted]
PHST- 2022/07/08 06:00 [pubmed]
PHST- 2022/11/16 06:00 [medline]
PHST- 2022/07/07 04:43 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - 10.1111/jdv.18413 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2022 Dec;36(12):2482-2487. doi: 10.1111/jdv.18413. 
      Epub 2022 Jul 13.