PMID- 35797816
OWN - NLM
STAT- MEDLINE
DCOM- 20220810
LR  - 20220810
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 77
DP  - 2022 Aug
TI  - Artiodactyl livestock species have a uniform vomeronasal system with a 
      vomeronasal type 1 receptor (V1R) pathway.
PG  - 101863
LID - S0040-8166(22)00135-5 [pii]
LID - 10.1016/j.tice.2022.101863 [doi]
AB  - Artiodactyl livestock animals have a vomeronasal system that detects pheromones. 
      Vomeronasal receptors comprise type 1 (V1R) coupled with G protein alpha-i2 (Galphai2) 
      and type 2 (V2R) coupled with G protein alpha-o (Galphao). Laboratory rodents have two 
      segregated V1R and V2R pathways that reach separately to the accessory olfactory 
      bulb (AOB). In contrast, the AOBs of goats and sheep are entirely positive for 
      Galphai2, indicating that they have only the V1R pathway. However, we detected a few 
      V2R genes in the genome of cattle, goats, sheep and pigs by genome assembly. 
      Thus, we immunohistochemically analyzed the AOBs of cattle and pigs to confirm 
      which type of the vomeronasal system is present in artiodactyl livestock species. 
      The glomerular layer of the AOB in cattle and pigs was entirely positive for 
      anti-Galphai2 and weakly positive for anti-Galphao, as in the V1R uniform type of 
      vomeronasal system in other mammal species. These findings indicated that 
      artiodactyl livestock species have a uniform type of vomeronasal system composing 
      the V1R pathway. Therefore, caution is advised when extrapolating knowledge of 
      laboratory rodents with two vomeronasal pathways to livestock animals that have 
      one.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Kondoh, Daisuke
AU  - Kondoh D
AD  - Laboratory of Veterinary Anatomy, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. Electronic address: 
      kondoh-d@obihiro.ac.jp.
FAU - Kawai, Yusuke K
AU  - Kawai YK
AD  - Laboratory of Toxicology, Obihiro University of Agriculture and Veterinary 
      Medicine, Obihiro, Hokkaido 080-8555, Japan.
FAU - Watanabe, Kenichi
AU  - Watanabe K
AD  - Laboratory of Veterinary Pathology, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
FAU - Muranishi, Yuki
AU  - Muranishi Y
AD  - Department of Life and Food Sciences, Obihiro University of Agriculture and 
      Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220630
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - GTP-Binding Proteins/metabolism
MH  - Goats/metabolism
MH  - Livestock/metabolism
MH  - Olfactory Bulb/metabolism
MH  - Sheep
MH  - Swine
MH  - *Vomeronasal Organ/metabolism
OTO - NOTNLM
OT  - Brain
OT  - Chemoreception
OT  - Mammals
OT  - Olfactory system
EDAT- 2022/07/08 06:00
MHDA- 2022/08/11 06:00
CRDT- 2022/07/07 18:20
PHST- 2022/04/10 00:00 [received]
PHST- 2022/06/07 00:00 [revised]
PHST- 2022/06/28 00:00 [accepted]
PHST- 2022/07/08 06:00 [pubmed]
PHST- 2022/08/11 06:00 [medline]
PHST- 2022/07/07 18:20 [entrez]
AID - S0040-8166(22)00135-5 [pii]
AID - 10.1016/j.tice.2022.101863 [doi]
PST - ppublish
SO  - Tissue Cell. 2022 Aug;77:101863. doi: 10.1016/j.tice.2022.101863. Epub 2022 Jun 
      30.