PMID- 35799727
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1682-024X (Print)
IS  - 1681-715X (Electronic)
IS  - 1681-715X (Linking)
VI  - 38
IP  - 5
DP  - 2022 May-Jun
TI  - Correlation between helicobacter pylori infection and iron deficiency in 
      children.
PG  - 1188-1192
LID - 10.12669/pjms.38.5.5175 [doi]
AB  - OBJECTIVES: To investigate the correlation between Helicobacter pylori (Hp) 
      infection and Iron deficiency (ID) in children. METHODS: This cross-sectional 
      study was conducted at Baoding Children's Hospital from January 2018 to December 
      2019. A total of one thousand children who came to our hospital for physical 
      examination and met the inclusion criteria were continuously included in this 
      study. All the children were given questionnaires (personal and family social and 
      economic status), a stool Hp antigen test and/or a 13C-urea breath test, as well 
      as measurements of hemoglobin (Hb), mean red blood cell volume (MCV), red blood 
      cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), 
      serum ferritin (SF), serum iron (SI), and total iron binding capacity (TIBC). 
      Children who tested positive for Hp were divided into the Hp group and children 
      who tested negative for Hp were divided into the control group. ID or IDA was 
      diagnosed based on the child's blood test results. RESULTS: A total of 902 
      children met the inclusion criteria, including 194 (21.5%) in the Hp group and 
      708 (78.5%) in the control group. The incidence of ID and IDA in Hp group was 
      higher than that in control group (2=9.112, 2=4.478; All P < 0.05); The levels of 
      MCV, SI, SF and Hb in Hp group were lower than those in control group (t=5.288; T 
      = 3.864; T = 6.751; T =11.841, all P < 0.05), TIBC level was higher than that of 
      control group (T =7.630, P < 0.05); The levels of MCHC and RDW in THE Hp group 
      were not statistically significant compared with the control group. Logistic 
      regression showed that Hp infection was not a combined risk factor for ID. Older 
      age, higher educational background of the mother, living in the city, and higher 
      family income were the combined protective factors to prevent the occurrence of 
      ID in children. CONCLUSION: Hp infection is not a combined risk factor for the 
      development of ID in children. The influence of family social and economic 
      factors should be taken into consideration when analyzing the correlation between 
      Hp infection and ID.
CI  - Copyright: (c) Pakistan Journal of Medical Sciences.
FAU - Zhang, Yuanda
AU  - Zhang Y
AD  - Yuanda Zhang, Department of Nutrition, Baoding Key Laboratory of Clinical 
      Research on Children's Respiratory and Digestive Diseases, Baoding, Hebei, 
      071000, P.R. China.
FAU - Bi, Jing
AU  - Bi J
AD  - Jing Bi, Department of Infectious Diseases, Baoding Laboratory for Accurate 
      Diagnosis and Treatment of Pediatric Infectious Diseases, Baoding, Hebei, 071000, 
      P.R. China.
FAU - Wang, Meiying
AU  - Wang M
AD  - Meiying Wang, Department of Clinical Laboratory, Baoding Children's Hospital, 
      Baoding, Hebei, 071000, P.R. China.
FAU - Deng, Hongyu
AU  - Deng H
AD  - Hongyu Deng, Department of Clinical Laboratory, Affiliated Hospital of Hebei 
      University 071000, China.
FAU - Yang, Wenli
AU  - Yang W
AD  - Wenli Yang, Department of Clinical Nutrition, Beijing Children's Hospital, 
      Capital Medical University, National Children's Medical Center, Beijing 100045, 
      China.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - Pak J Med Sci
JT  - Pakistan journal of medical sciences
JID - 100913117
PMC - PMC9247760
OTO - NOTNLM
OT  - Children
OT  - Helicobacter pylori
OT  - Iron deficiency
OT  - Questionnaire
COIS- Conflicts of interest: None.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/05/01
CRDT- 2022/07/08 02:36
PHST- 2021/08/13 00:00 [received]
PHST- 2022/01/28 00:00 [revised]
PHST- 2022/02/08 00:00 [revised]
PHST- 2022/02/18 00:00 [accepted]
PHST- 2022/07/08 02:36 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/05/01 00:00 [pmc-release]
AID - PJMS-38-1188 [pii]
AID - 10.12669/pjms.38.5.5175 [doi]
PST - ppublish
SO  - Pak J Med Sci. 2022 May-Jun;38(5):1188-1192. doi: 10.12669/pjms.38.5.5175.