PMID- 35799926
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 12
IP  - 29
DP  - 2022 Jun 22
TI  - Exosome-based drug delivery systems and their therapeutic applications.
PG  - 18475-18492
LID - 10.1039/d2ra02351b [doi]
AB  - In the past few decades, scientists have actively worked on developing effective 
      drug delivery systems (DDSs) as means to control life-threatening diseases and 
      challenging illnesses. In order to develop such DDSs, nanobiotechnological 
      strategies have been introduced, and many nanomaterial-based DDS platforms have 
      been proposed. Among these nanomaterials, DDSs based on exosomes and hybrids of 
      exosomes have been focused upon and developed due to their low toxicity, high 
      bioactivity, and biocompatibility. In this review, we describe the processes 
      involved in drug loading into exosomes and the surface modification of exosomes 
      with treatment agents. Furthermore, we describe the synthesis methods of hybrid 
      exosomes with organic or inorganic nanoparticles. Moreover, we focus on the 
      effective therapeutic applications of exosome-based DDSs against various 
      diseases. In conclusion, we show that exosomes and hybrids of exosomes show 
      excellent drug carrier potential and capacity.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Lee, Jaewook
AU  - Lee J
AUID- ORCID: 0000-0001-7142-1724
AD  - 4D Convergence Technology Institute (National Key Technology Institute in 
      University), Korea National University of Transportation Jeungpyeong Chung-Buk 
      27909 Republic of Korea leeyk@ut.ac.kr +82-43-841-5224.
FAU - Lee, Ji-Heon
AU  - Lee JH
AD  - 4D Convergence Technology Institute (National Key Technology Institute in 
      University), Korea National University of Transportation Jeungpyeong Chung-Buk 
      27909 Republic of Korea leeyk@ut.ac.kr +82-43-841-5224.
FAU - Chakraborty, Kushal
AU  - Chakraborty K
AD  - Department of IT and Energy Convergence (BK21 FOUR), Korea National University of 
      Transportation Chungju Chung-Buk 27469 Republic of Korea.
FAU - Hwang, Joon
AU  - Hwang J
AD  - 4D Convergence Technology Institute (National Key Technology Institute in 
      University), Korea National University of Transportation Jeungpyeong Chung-Buk 
      27909 Republic of Korea leeyk@ut.ac.kr +82-43-841-5224.
AD  - Department of Aeronautical & Mechanical Design Engineering, Korea National 
      University of Transportation Chungju Chung-Buk 27469 Republic of Korea.
FAU - Lee, Yong-Kyu
AU  - Lee YK
AD  - 4D Convergence Technology Institute (National Key Technology Institute in 
      University), Korea National University of Transportation Jeungpyeong Chung-Buk 
      27909 Republic of Korea leeyk@ut.ac.kr +82-43-841-5224.
AD  - Department of Chemical and Biological Engineering, Korea National University of 
      Transportation Chungju Chung-Buk 27469 Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220623
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9218984
COIS- Authors declare no conflicts of interest.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/06/23
CRDT- 2022/07/08 02:39
PHST- 2022/04/12 00:00 [received]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/07/08 02:39 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/06/23 00:00 [pmc-release]
AID - d2ra02351b [pii]
AID - 10.1039/d2ra02351b [doi]
PST - epublish
SO  - RSC Adv. 2022 Jun 23;12(29):18475-18492. doi: 10.1039/d2ra02351b. eCollection 
      2022 Jun 22.