PMID- 35800278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2224-4344 (Print)
IS  - 2224-4344 (Electronic)
IS  - 2224-4336 (Linking)
VI  - 11
IP  - 6
DP  - 2022 Jun
TI  - Systematic review and meta-analysis of the incidence rates of adverse events 
      after digestive endoscopy in children.
PG  - 920-932
LID - 10.21037/tp-22-179 [doi]
AB  - BACKGROUND: With the widespread use of digestive endoscopy in children, a variety 
      of adverse events (AEs) have occurred after digestive endoscopy. However, there 
      are notable differences in the incidence of adverse reactions in digestive 
      endoscopy in children at present, which makes it difficult to assess the safety 
      of digestive endoscopy in children. METHODS: Studies related to digestive 
      endoscopy in children were screened from January 2005 to October 2021 from 
      PubMed, Web of Science, Spring, CNKI, and Science Direct databases. RevMan5.3 and 
      Stata were employed to carry out meta-analysis on the incidence of adverse 
      respiratory events, myoclonus, abdominal pain, fever, bleeding, chest pain, sore 
      throat, vomiting, and delayed capsule discharge after digestive endoscopy in 
      children. The article quality was evaluated by the Agency for Healthcare Research 
      and Quality (AHRQ). The chi-square test and I(2) were adopted to test literature 
      heterogeneity, and the article publication bias was assessed by displaying an 
      inverted funnel plot as a funnel plot. RESULTS: In all, 15 articles were 
      included, involving a total of 27,770 children. In all, 15 articles were 
      included, involving a total of 27,770 children. The risk ratio (RR) value of 
      adverse respiratory events after digestive endoscopy in children was 1.31 [95% 
      confidence interval (CI): 1.17 to 1.47, P<0.00001]; the odds ratio (OR) value of 
      the incidence of myoclonus was 1.21 (95% CI: 1.01 to 1.46, P=0.04); the incidence 
      of abdominal pain was 1.18 (95% CI: 1.11 to 1.27, P<0.00001); the incidence of 
      fever was 1.09 (95% CI: 1.06 to 1.12, P<0.00001); the incidence of bleeding was 
      1.24 (95% CI: 0.94 to 1.64, P=0.13); the incidence of chest pain was 1.06 (95% 
      CI: 1.03 to 1.09, P<0.0001); incidence of sore throat was 1.11 (95% CI: 1.05 to 
      1.18, P=0.0004); incidence of vomiting was 1.13 (95% CI: 1.06 to 1.21, P=0.0001); 
      and the incidence of delayed capsule expulsion was 1.18 (95% CI: 1.00 to 1.40, 
      P=0.05). DISCUSSION: The incidence of AEs after digestive endoscopy in children 
      was low, which can be used in the diagnosis and therapy of digestive system 
      diseases in children.
CI  - 2022 Translational Pediatrics. All rights reserved.
FAU - Meng, Liying
AU  - Meng L
AD  - Department of Gastroenterology, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
FAU - Fan, Xueke
AU  - Fan X
AD  - Department of Gastroenterology, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
FAU - Zhang, Aiguo
AU  - Zhang A
AD  - Department of Gastroenterology, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
FAU - Su, Hongjie
AU  - Su H
AD  - Department of Pediatrics, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
FAU - Zhang, Haijun
AU  - Zhang H
AD  - Department of Pediatrics, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
FAU - Tian, Yajuan
AU  - Tian Y
AD  - Department of Gastroenterology, Jincheng People's Hospital (Jincheng Hospital 
      Affiliated to Changzhi Medical College), Jincheng, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Pediatr
JT  - Translational pediatrics
JID - 101649179
PMC - PMC9253955
OTO - NOTNLM
OT  - Children
OT  - adverse events (AEs)
OT  - digestive endoscopy
OT  - meta-analysis
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://tp.amegroups.com/article/view/10.21037/tp-22-179/coif). The authors have 
      no conflicts of interest to declare.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/06/01
CRDT- 2022/07/08 02:47
PHST- 2022/04/07 00:00 [received]
PHST- 2022/06/14 00:00 [accepted]
PHST- 2022/07/08 02:47 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - tp-11-06-920 [pii]
AID - 10.21037/tp-22-179 [doi]
PST - ppublish
SO  - Transl Pediatr. 2022 Jun;11(6):920-932. doi: 10.21037/tp-22-179.