PMID- 35800352
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2223-3652 (Print)
IS  - 2223-3660 (Electronic)
IS  - 2223-3652 (Linking)
VI  - 12
IP  - 3
DP  - 2022 Jun
TI  - Dual energy CT based scoring in chronic thromboembolic pulmonary hypertension and 
      correlation with clinical and hemodynamic parameters: a retrospective 
      cross-sectional study.
PG  - 305-313
LID - 10.21037/cdt-21-686 [doi]
AB  - BACKGROUND: We used a dual energy computed tomography (DECT) based scoring system 
      in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and 
      correlated it with functional and hemodynamic parameters. METHODS: This was a 
      retrospective study on 78 patients with CTEPH who underwent DECT. First, clot 
      burden score was calculated by assigning a following score: pulmonary trunk-5, 
      each main pulmonary artery-4, each lobar-3, each segmental-2, and subsegmental-1 
      per lobe; sum total was then calculated. Perfusion defect (PD) score was 
      calculated by assigning 1 point to each segmental PD. Combined score was 
      calculated by adding the clot burden and PD score. All three scores were 
      correlated with clinical and hemodynamic parameters that included New York Heart 
      Association (NYHA) functional class, 6-minute walk distance (6MWT) in feet, 
      forced expiratory volume in one second (FEV1), forced vital capacity (FVC), 
      diffusing capacity of the lung for carbon monoxide (DLCO), pulmonary arterial 
      pressure (PAP) [systolic PAP (sPAP), diastolic PAP (dPAP) and mean PAP (mPAP)], 
      pulmonary vascular resistance (PVR), right atrial pressure, cardiac output, and 
      cardiac index. RESULTS: Clot burden score, PD score, and combined score all 
      positively correlated with sPAP (0.25, 0.34, 0.34), PVR (0.27, 0.30, 0.34), and 
      mPAP (0.28, 0.31, 0.36). There was no statistically significant correlation of 
      clot burden score, PD score and combined score with 6MWT, % predicted 6MWT, FEV1, 
      FEV1%, FVC, FVC%, DLCO% and NYHA functional class. CONCLUSIONS: DECT based 
      scoring in CTEPH is feasible and correlates positively with sPAP, mPAP and PVR. 
      Combined score has the highest magnitude of correlation.
CI  - 2022 Cardiovascular Diagnosis and Therapy. All rights reserved.
FAU - Abozeed, Mostafa
AU  - Abozeed M
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
FAU - Conic, Sofija
AU  - Conic S
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
FAU - Bullen, Jennifer
AU  - Bullen J
AD  - Quantitative Health Sciences, Cleveland Clinic, OH, USA.
FAU - Rizk, Alain
AU  - Rizk A
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
FAU - Saeedan, Mnahi Bin
AU  - Saeedan MB
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
FAU - Karim, Wadih
AU  - Karim W
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
FAU - Heresi, Gustavo A
AU  - Heresi GA
AD  - Department of Pulmonary and Critical Care Medicine, Respiratory Institute, 
      Cleveland Clinic, OH, USA.
FAU - Renapurkar, Rahul D
AU  - Renapurkar RD
AD  - Sections of Thoracic and Cardiovascular Imaging Laboratory, Imaging Institute, 
      Cleveland Clinic, OH, USA.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Cardiovasc Diagn Ther
JT  - Cardiovascular diagnosis and therapy
JID - 101601613
PMC - PMC9253168
OTO - NOTNLM
OT  - Pulmonary embolism (PE)
OT  - multidetector computed tomography
OT  - pulmonary hypertension (PH)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://cdt.amegroups.com/article/view/10.21037/cdt-21-686/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/06/01
CRDT- 2022/07/08 02:49
PHST- 2021/10/27 00:00 [received]
PHST- 2022/04/02 00:00 [accepted]
PHST- 2022/07/08 02:49 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/06/01 00:00 [pmc-release]
AID - cdt-12-03-305 [pii]
AID - 10.21037/cdt-21-686 [doi]
PST - ppublish
SO  - Cardiovasc Diagn Ther. 2022 Jun;12(3):305-313. doi: 10.21037/cdt-21-686.