PMID- 35800477
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2249-4863 (Print)
IS  - 2278-7135 (Electronic)
IS  - 2249-4863 (Linking)
VI  - 11
IP  - 5
DP  - 2022 May
TI  - Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A 
      comparative study.
PG  - 1845-1850
LID - 10.4103/jfmpc.jfmpc_1696_20 [doi]
AB  - OBJECTIVE: To compare the efficacy of oral nifedipine and parenteral isoxsuprine 
      in arresting preterm labor. Considering the paucity of studies comparing these 
      two agents, a comparative analysis is obligatory. MATERIALS AND METHODS: Eighty 
      antenatal women in the gestational age range of 28-37 weeks, with regular uterine 
      contractions, cervical dilatation </=3 cm, and <50% cervical effacement, admitted 
      with complaints of preterm labor pain were randomized to receive either 40 mg 
      isoxsuprine or 20 mg nifedipine. Efficacy of the drugs was measured in terms of 
      arrest of preterm labor, prolongation of pregnancy, and the days gained by infant 
      before birth. RESULTS: Isoxsuprine showed increased lowering of systolic blood 
      pressure (SBP), diastolic blood pressure (DBP), and slightly higher maternal 
      pulse rate, but higher fetal pulse rate post-administration in comparison to 
      nifedipine (P < 0.05). Isoxsuprine was significantly associated with more side 
      effects. Pregnancy was more prolonged in the nifedipine group (25 days) than in 
      the isoxsuprine group (19 days) (P < 0.05). The birth weight of neonates in group 
      B was more than that of neonates in group A (P < 0.05). At 5 min after birth, 
      none of the neonates in group B had an Appearance, Pulse, Grimace, Activity, and 
      Respiration (APGAR) abnormal score <7, compared to neonates in group A. Majority 
      of neonates in group A showed tachycardia and respiratory distress syndrome (RDS) 
      (17.5% and 12.5%, respectively), compared to group B (12.5% and 7.5%, 
      respectively). The overall success rate was better in group B (86.8%) compared to 
      group A (80%). CONCLUSION: Nifedipine was slightly more effective in arresting 
      preterm labor with fewer side effects, compared to isoxsuprine.
CI  - Copyright: (c) 2022 Journal of Family Medicine and Primary Care.
FAU - Ray, Namrata
AU  - Ray N
AD  - Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences, 
      Karad, Maharashtra, India.
FAU - Kshirsagar, Nitin
AU  - Kshirsagar N
AD  - Department of Obstetrics and Gynecology, Krishna Institute of Medical Sciences, 
      Karad, Maharashtra, India.
LA  - eng
PT  - Journal Article
DEP - 20220514
PL  - India
TA  - J Family Med Prim Care
JT  - Journal of family medicine and primary care
JID - 101610082
PMC - PMC9254824
OTO - NOTNLM
OT  - Gestational Age
OT  - isoxsuprine
OT  - nifedipine
OT  - pregnancy
OT  - tocolysis
COIS- There are no conflicts of interest.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/05/01
CRDT- 2022/07/08 02:51
PHST- 2020/08/19 00:00 [received]
PHST- 2020/10/27 00:00 [revised]
PHST- 2022/02/04 00:00 [accepted]
PHST- 2022/07/08 02:51 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/05/01 00:00 [pmc-release]
AID - JFMPC-11-1845 [pii]
AID - 10.4103/jfmpc.jfmpc_1696_20 [doi]
PST - ppublish
SO  - J Family Med Prim Care. 2022 May;11(5):1845-1850. doi: 
      10.4103/jfmpc.jfmpc_1696_20. Epub 2022 May 14.