PMID- 35801048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 10
IP  - 15
DP  - 2022 May 26
TI  - Solitary primary pulmonary synovial sarcoma: A case report.
PG  - 5103-5110
LID - 10.12998/wjcc.v10.i15.5103 [doi]
AB  - BACKGROUND: Synovial sarcoma (SS) is an uncommon and highly malignant soft tissue 
      sarcoma in the clinic, with primary pulmonary SS (PPSS) being extremely rare. 
      Here, we describe the clinical characteristics, diagnosis, and treatment of a 
      solitary PPSS case confirmed via surgical resection and fluorescence in situ 
      hybridization (FISH). CASE SUMMARY: A 33-year-old man was admitted because of 
      intermittent coughing and hemoptysis for one month, with lung shadows observed 
      for two years. Whole-body positron emission tomography-computed tomography 
      (PET-CT) revealed a solitary mass in the upper lobe of the right lung, with 
      uneven radioactivity uptake and a maximum standardized uptake value of 5.6. The 
      greyish-yellow specimen obtained following thoracoscopic resection was covered 
      with small multi-nodulated structures and consisted of soft tissue. Hematoxylin 
      and eosin staining revealed spindle-shaped malignant tumor cells. 
      Immunohistochemistry indicated these tumor cells were CD99 and BCL-2-positive. 
      Furthermore, the FISH test revealed synovial sarcoma translocation genetic 
      reassortment, which confirmed the diagnosis of SS. CONCLUSION: PPSS is extremely 
      rare and tends to be misdiagnosed as many primary pulmonary diseases. PET-CT, 
      histologic analysis, and FISH tests can be used to differentiate PPSS from other 
      diseases. Surgical resection is regularly recommended for the treatment of 
      solitary PPSS and is helpful for improving the prognosis.
CI  - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - He, Wei-Wei
AU  - He WW
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China.
FAU - Huang, Zhi-Xin
AU  - Huang ZX
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China.
FAU - Wang, Wen-Jing
AU  - Wang WJ
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China.
FAU - Li, Yu-Lei
AU  - Li YL
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China.
FAU - Xia, Qiu-Yuan
AU  - Xia QY
AD  - Department of Pathology, Jinling Hospital, Nanjing 210002, Jiangsu Province, 
      China.
FAU - Qiu, Yong-Bin
AU  - Qiu YB
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China.
FAU - Shi, Yi
AU  - Shi Y
AD  - Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing 
      210002, Jiangsu Province, China.
FAU - Sun, Hui-Ming
AU  - Sun HM
AD  - Department of Respiratory and Critical Care Medicine, Nanjing Yimin Hospital, 
      Nanjing 210000, Jiangsu Province, China. shm-icu@163.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC9198894
OTO - NOTNLM
OT  - Case report
OT  - Fluorescence in situ hybridization
OT  - Positron emission tomography-computed tomography
OT  - Primary pulmonary synovial sarcoma
OT  - Solitary pulmonary nodule
OT  - Spindle cells
OT  - Synovial sarcoma translocation
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/09 06:01
PMCR- 2022/05/26
CRDT- 2022/07/08 02:58
PHST- 2021/12/22 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/03/27 00:00 [accepted]
PHST- 2022/07/08 02:58 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/09 06:01 [medline]
PHST- 2022/05/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v10.i15.5103 [doi]
PST - ppublish
SO  - World J Clin Cases. 2022 May 26;10(15):5103-5110. doi: 
      10.12998/wjcc.v10.i15.5103.