PMID- 35801704
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221107
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 276
IP  - 5
DP  - 2022 Nov 1
TI  - Measuring Quality of Life in Chronic Limb-threatening Ischemia Patients and 
      Informal Carers: A Scoping Review.
PG  - e331-e341
LID - 10.1097/SLA.0000000000005477 [doi]
AB  - OBJECTIVE: To review quality of life (QOL) instruments for chronic 
      limb-threatening ischemia (CLTI) patients and informal carers, and their use in 
      QOL and cost-utility analysis (CUA) studies. BACKGROUND: CLTI is a global health 
      problem with significant morbidity affecting patients and informal carers. QOL is 
      increasingly measured for holistic outcomes assessment and CUA. However, 
      measurement instruments in CLTI are poorly understood. METHODS: MEDLINE, EMBASE, 
      PsycINFO, CINAHL, COSMIN, PROQOLID, CEA registry, and NHS EED databases were 
      searched for all English language studies up to May 2021. Features of 
      instruments, evidence of measurement property appraisal, and trends in use were 
      assessed. Prospective protocol registration (Open Science Framework: 
      https://doi.org/10.17605/OSF.IO/KNG9U ). RESULTS: A total of 146 studies on QOL 
      instruments (n=43), QOL outcomes (n=97), and CUA (n=9) were included. Four 
      disease-specific QOL instruments are available for lower extremity arterial 
      disease (intermittent claudication or CLTI). VascuQoL-25 and VascuQoL-6 have been 
      used in CLTI. There is no CLTI-specific instrument. Of 14 generic instruments, 
      SF-36, EQ-5D-3L, NHP, and WHOQOL-BREF were most common. Studies reporting partial 
      measurement property appraisal favored VascuQoL-25, VascuQoL-6, and SF-36. 
      Feasibility considerations include mode of administration and responder burden. 
      None of 4 available carer-specific instruments have been used in CLTI. Since 
      1992, the number of QOL studies has increased considerably, but CUA studies are 
      scarce. Informal carers have not been assessed. CONCLUSIONS: This review provides 
      a comprehensive reference for QOL measurement in CLTI that helps end-users with 
      instrument selection, use, and interpretation. However, a CLTI-specific 
      instrument is needed. There is an opportunity to benefit society through future 
      CUA studies and evaluation of QOL in informal carers.
CI  - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Shan, Leonard L
AU  - Shan LL
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Vic., Australia.
FAU - Shi, Margaret D Y
AU  - Shi MDY
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Vic., Australia.
FAU - Tew, Michelle
AU  - Tew M
AD  - Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry 
      and Health Sciences, The University of Melbourne, Melbourne, Vic., Australia.
FAU - Westcott, Mark J
AU  - Westcott MJ
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Vic., Australia.
FAU - Davies, Alun H
AU  - Davies AH
AD  - Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, 
      UK.
FAU - Choong, Peter F
AU  - Choong PF
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Vic., Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220708
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
MH  - *Caregivers
MH  - Chronic Limb-Threatening Ischemia
MH  - Humans
MH  - Intermittent Claudication
MH  - Ischemia
MH  - Prospective Studies
MH  - *Quality of Life
COIS- The authors report no conflicts of interest.
EDAT- 2022/07/09 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/07/08 08:02
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/07/08 08:02 [entrez]
AID - 00000658-202211000-00039 [pii]
AID - 10.1097/SLA.0000000000005477 [doi]
PST - ppublish
SO  - Ann Surg. 2022 Nov 1;276(5):e331-e341. doi: 10.1097/SLA.0000000000005477. Epub 
      2022 Jul 8.