PMID- 35801771
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 27
DP  - 2022 Jul 8
TI  - Significance of immunohistochemistry and FISH of TFE3 in the diagnosis of 
      alveolar soft part sarcoma: A case report.
PG  - e29861
LID - 10.1097/MD.0000000000029861 [doi]
LID - e29861
AB  - RATIONALE: Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma 
      harboring an ASPL-TFE3 fusion gene. Herein, we report a case of ASPS associated 
      with brain metastasis. Immunohistochemistry (IHC) for TFE3 antigen expression and 
      fluorescence in situ hybridization (FISH) for TFE3 rearrangement were performed 
      to arrive at an accurate diagnosis. PATIENT CONCERNS: A 47-year-old man was 
      hospitalized for a headache and numbness of the lower limbs. DIAGNOSES: 
      Preoperative computed tomography and magnetic resonance imaging revealed 2 brain 
      masses, 1 each in the right parietal and temporal bones. We diagnosed this case 
      as ASPS with brain metastasis based on histological morphology, IHC, and FISH. 
      INTERVENTIONS: The patient underwent right skull titanium mesh implantation and 
      supratentorial superficial lesion resection. OUTCOMES: : The patient recovered 
      well after discharged from hospital. LESSONS: The diagnosis of ASPS depends on 
      careful clinical, radiographic, histopathological, IHC, and FISH assessments to 
      arrive at the correct diagnosis. Thus, TFE3 may be useful in the diagnosis and 
      treatment of ASPS.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Huang, Yan-Ying
AU  - Huang YY
AUID- ORCID: 0000-0003-3141-7936
AD  - Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 
      People's Republic of China.
FAU - Yang, Wan-Rui
AU  - Yang WR
AD  - Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 
      People's Republic of China.
FAU - Geng, Yan-Hua
AU  - Geng YH
AD  - Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 
      People's Republic of China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Radiology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, 
      People's Republic of China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220708
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TFE3 protein, human)
SB  - IM
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
MH  - *Brain Neoplasms
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Intracellular Signaling Peptides and Proteins/genetics
MH  - Oncogene Proteins, Fusion/genetics
MH  - *Sarcoma, Alveolar Soft Part/pathology
PMC - PMC9259144
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2022/07/09 06:00
MHDA- 2022/07/12 06:00
PMCR- 2022/07/08
CRDT- 2022/07/08 08:13
PHST- 2022/07/08 08:13 [entrez]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2022/07/08 00:00 [pmc-release]
AID - 00005792-202207080-00042 [pii]
AID - 10.1097/MD.0000000000029861 [doi]
PST - epublish
SO  - Medicine (Baltimore). 2022 Jul 8;101(27):e29861. doi: 
      10.1097/MD.0000000000029861.