PMID- 35801815 OWN - NLM STAT- MEDLINE DCOM- 20220809 LR - 20221015 IS - 1475-1313 (Electronic) IS - 0275-5408 (Print) IS - 0275-5408 (Linking) VI - 42 IP - 5 DP - 2022 Sep TI - Short-term tear film stability, optical quality and visual performance in two dual-focus contact lenses for myopia control with different optical designs. PG - 1062-1073 LID - 10.1111/opo.13024 [doi] AB - PURPOSE: To assess and compare short-term visual and optical quality and tear film stability between two dual-focus (DF) prototype myopia control contact lenses (CLs) having different inner zone diameters. METHODS: Twenty-eight myopic subjects were included in this randomised, double-masked crossover study. Refraction, best-corrected visual acuity (VA) and tear film stability were measured at baseline (i.e., when uncorrected). Subjects were then binocularly fitted with the DF CLs, with only the sensorial dominant eye being assessed. Lenses were of the same material and had inner zone diameters of either 2.1 mm (S design) or 4.0 mm (M design). Visual and physical short-term lens comfort, over-refraction, best-corrected VA, stereopsis at 40 cm, best-corrected photopic and mesopic contrast sensitivity (CS), size and shape of light disturbance (LD), wavefront aberrations, subjective quality of vision (QoV Questionnaire) and tear film stability were measured for each lens. RESULTS: Both CL designs decreased tear film stability compared with baseline (p < 0.05). VA and photopic CS were within normal values for the subjects' age with each CL. When comparing lenses, the M design promoted better photopic CS for the 18 cycles per degree spatial frequency (p < 0.001) and better LD (p < 0.02). However, higher-order aberrations were improved with the S design (p = 0.02). No significant difference between the two CLs was found for QoV scores and tear film stability. CONCLUSIONS: Both DF CLs provided acceptable visual performance under photopic conditions. The 4.0 mm inner zone gave better contrast sensitivity at high frequencies and lower light disturbance, while the 2.1 mm central diameter induced fewer higher-order aberrations for a 5 mm pupil diameter. Both CLs produced the same subjective visual short-term lens comfort. CI - (c) 2022 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. FAU - Garcia-Marques, Jose Vicente AU - Garcia-Marques JV AUID- ORCID: 0000-0001-8938-5194 AD - Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain. FAU - Macedo-De-Araujo, Rute Juliana AU - Macedo-De-Araujo RJ AUID- ORCID: 0000-0003-3664-4273 AD - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal. FAU - McAlinden, Colm AU - McAlinden C AUID- ORCID: 0000-0002-4517-4616 AD - Department of Ophthalmology, Royal Gwent Hospital, Newport, UK. AD - Wenzhou Medical University, Wenzhou, China. AD - Eye & ENT Hospital of Fudan University, Shanghai, China. FAU - Faria-Ribeiro, Miguel AU - Faria-Ribeiro M AUID- ORCID: 0000-0002-4880-9680 AD - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal. FAU - Cervino, Alejandro AU - Cervino A AUID- ORCID: 0000-0001-8014-3279 AD - Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain. FAU - Gonzalez-Meijome, Jose Manuel AU - Gonzalez-Meijome JM AUID- ORCID: 0000-0001-9050-4170 AD - Clinical and Experimental Optometry Research Laboratory (CEORLab) Center of Physics (Optometry), School of Sciences, University of Minho, Braga, Portugal. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20220708 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - *Contact Lenses MH - *Contact Lenses, Hydrophilic MH - Contrast Sensitivity MH - Cross-Over Studies MH - Humans MH - *Myopia/therapy MH - Refraction, Ocular MH - Visual Acuity PMC - PMC9540637 OTO - NOTNLM OT - light disturbance OT - multifocal contact lens OT - myopia control OT - tear film stability OT - visual performance OT - visual quality COIS- Jose Manuel Gonzalez Meijome and Rute J Macedo-de-Araujo have a proprietary interest in the light disturbance analyser. EDAT- 2022/07/09 06:00 MHDA- 2022/08/10 06:00 PMCR- 2022/10/07 CRDT- 2022/07/08 08:22 PHST- 2022/06/20 00:00 [revised] PHST- 2022/02/22 00:00 [received] PHST- 2022/06/20 00:00 [accepted] PHST- 2022/07/09 06:00 [pubmed] PHST- 2022/08/10 06:00 [medline] PHST- 2022/07/08 08:22 [entrez] PHST- 2022/10/07 00:00 [pmc-release] AID - OPO13024 [pii] AID - 10.1111/opo.13024 [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2022 Sep;42(5):1062-1073. doi: 10.1111/opo.13024. Epub 2022 Jul 8.