PMID- 35802317
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220809
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 36
DP  - 2022 Aug
TI  - National probabilistic risk assessment of newly registered pesticides in 
      agricultural products to propose maximum residue limit (MRL).
PG  - 55311-55320
LID - 10.1007/s11356-022-21825-3 [doi]
AB  - Following the EPA recommended method, a chronic diet risk assessment for 
      pesticides was recently performed for adults and children in the Iranian 
      population. The National Theoretical Maximum Daily Intake (NTMDI) for 32 
      pesticides was computed using the theoretical maximum residue limits (MRLs) of 
      food consumption regulations and data from the comprehensive database of the 
      Iranian Research Institute of Plant Protection (IRIPP). The risk was assessed by 
      comparing TMDI with the acceptable daily intakes (ADI) evaluated by FAO. From 32 
      investigated pesticides, 10 pesticides had TMDI > 65% of the ADI. Some of these 
      ADI-exceeding compounds (spirodiclofen, abamectin, trifloxystrobin, spiromesifen, 
      fipronil, difenoconazole, tetraconazole) were found in citrus, cucumber, grapes, 
      tomato, and potato as the foods that have played the most roles in the 
      consumption of these pesticides. Furthermore, a probabilistic risk assessment was 
      performed to estimate the contingency of extravagance of the ADI. In the current 
      research, only cyazofamid in potato for children consumers exceeded the 1 of the 
      HQ. However, carcinogenic risk (CR) due to spirodiclofen in citrus fruit and 
      difenoconazole in tomato was higher than the 1E-6 value; therefore, consumers 
      were at considerable carcinogenic risk in these commodities. This scrutiny is 
      essential for improving the activities' risk assessment, regulation, and 
      surveillance.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Mahdavi, Vahideh
AU  - Mahdavi V
AD  - Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, 
      Education and Extension Organization (AREEO), P.O. Box 1475744741, Tehran, Iran. 
      v_mahdavi@areeo.ac.ir.
FAU - Gordan, Hasti
AU  - Gordan H
AD  - Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, 
      Education and Extension Organization (AREEO), P.O. Box 1475744741, Tehran, Iran.
FAU - Ramezani, Sara
AU  - Ramezani S
AD  - Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, 
      Education and Extension Organization (AREEO), P.O. Box 1475744741, Tehran, Iran.
FAU - Mousavi Khaneghah, Amin
AU  - Mousavi Khaneghah A
AUID- ORCID: 0000-0001-5769-0004
AD  - Department of Fruit and Vegetable Product Technology, Prof. Waclaw Dabrowski 
      Institute of Agricultural and Food Biotechnology-State Research Institute, 36 
      Rakowiecka St, 02-532, Warsaw, Poland. amin.mousavi@ibprs.pl.
LA  - eng
PT  - Journal Article
DEP - 20220708
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Pesticide Residues)
RN  - 0 (Pesticides)
SB  - IM
MH  - Food Contamination/analysis
MH  - Iran
MH  - *Pesticide Residues/analysis
MH  - *Pesticides/chemistry
MH  - Risk Assessment/methods
OTO - NOTNLM
OT  - Carcinogenic risk assessment
OT  - MRL
OT  - Non-carcinogenic risk assessment
OT  - Pesticides
OT  - TMDI
EDAT- 2022/07/09 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/08 11:20
PHST- 2022/01/29 00:00 [received]
PHST- 2022/06/29 00:00 [accepted]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/08 11:20 [entrez]
AID - 10.1007/s11356-022-21825-3 [pii]
AID - 10.1007/s11356-022-21825-3 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Aug;29(36):55311-55320. doi: 
      10.1007/s11356-022-21825-3. Epub 2022 Jul 8.