PMID- 35802331 OWN - NLM STAT- MEDLINE DCOM- 20221121 LR - 20221121 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 29 IP - 58 DP - 2022 Dec TI - Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China. PG - 87170-87183 LID - 10.1007/s11356-022-21817-3 [doi] AB - Bisphenols are endocrine disruptor chemicals that disrupt thyroid hormone homeostasis. However, evidence on the effects of bisphenol mixtures on thyroid hormones are insufficient. Therefore, the present study aimed to explore the effects of bisphenol substitutes and bisphenol mixtures on thyroid hormones during pregnancy. The study was conducted among 446 pregnant women in the Guangxi Zhuang Birth Cohort (GZBC), China. In multiple linear regressions, compared with the low-exposure group, bisphenol S (BPS) concentrations in the middle-exposure group led to a 10.90% (95% CI: - 18.16%, - 2.99%) decrease in triiodothyronine (T3) levels in the first trimester; tetrabromobisphenol A (TBBPA) levels in the middle-exposure group led to an 8.26% (95% CI: - 15.82%, - 0.01%) decrease in T3 levels in the first trimester; bisphenol B (BPB) levels in the middle-exposure group led to higher free thyroxine (FT4) levels (9.84%; 95% CI: 1.73%, 18.60%) in the second trimester; bisphenol F (BPF) in the middle-exposure group led to higher FT4 levels (8.59%, 95% CI: 0.53%, 17.31%) in the second trimester; and TBBPA levels in the high-exposure group led to a 9.39% (95% CI: 1.46%, 17.93%) increase in FT4 levels in the second trimester. The Bayesian kernel machine regression (BKMR) and restricted cubic spline (RCS) models showed a U-shaped dose-response relationship between bisphenol A (BPA) and free triiodothyronine (FT3) (p < 0.01) as well as BPS and FT4 (p < 0.05). Nonlinear relationships were also observed between the bisphenol mixture and FT3. Overall, maternal bisphenol exposure affected thyroid hormone levels during pregnancy. This study provides evidence that BPB, BPF, BPS, and TBBPA are unsafe substitutes for BPA, as well as the overall effect of bisphenols on adverse health in human beings. CI - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Huang, Huishen AU - Huang H AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Liang, Jun AU - Liang J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Tang, Peng AU - Tang P AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Yu, Chuanxiang AU - Yu C AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Fan, Haoran AU - Fan H AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Liao, Qian AU - Liao Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Long, Jinghua AU - Long J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Pan, Dongxiang AU - Pan D AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Zeng, Xiaoyun AU - Zeng X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. FAU - Qiu, Xiaoqiang AU - Qiu X AUID- ORCID: 0000-0001-9881-3664 AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, No.22 Shuangyong Road, Nanning, 530021, Guangxi, China. xqqiu9999@163.com. LA - eng GR - AB17195012/Guangxi Key Research Program/ GR - 81860587/National Natural Science Foundation of China/ PT - Journal Article DEP - 20220708 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - MLT3645I99 (bisphenol A) RN - 06LU7C9H1V (Triiodothyronine) RN - 1RC731TJJA (bisphenol B) RN - 0 (bisphenol F) RN - 0 (Benzhydryl Compounds) RN - 80-09-1 (bis(4-hydroxyphenyl)sulfone) RN - 0 (Thyroid Hormones) RN - FQI02RFC3A (tetrabromobisphenol A) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Triiodothyronine MH - Cohort Studies MH - *Pregnant Women MH - Prospective Studies MH - Birth Cohort MH - Bayes Theorem MH - China MH - Benzhydryl Compounds MH - Thyroid Hormones MH - Parturition OTO - NOTNLM OT - Birth cohort OT - Bisphenols OT - Pregnant women OT - Thyroid hormones EDAT- 2022/07/09 06:00 MHDA- 2022/11/22 06:00 CRDT- 2022/07/08 11:20 PHST- 2022/03/10 00:00 [received] PHST- 2022/06/29 00:00 [accepted] PHST- 2022/07/09 06:00 [pubmed] PHST- 2022/11/22 06:00 [medline] PHST- 2022/07/08 11:20 [entrez] AID - 10.1007/s11356-022-21817-3 [pii] AID - 10.1007/s11356-022-21817-3 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2022 Dec;29(58):87170-87183. doi: 10.1007/s11356-022-21817-3. Epub 2022 Jul 8.