PMID- 35803839
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220927
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 36
IP  - 8
DP  - 2022 Aug
TI  - Elastographic parameters of liver steatosis and fibrosis predict independently 
      the risk of incident chronic kidney disease and acute myocardial infarction in 
      patients with type 2 diabetes mellitus.
PG  - 108226
LID - S1056-8727(22)00132-5 [pii]
LID - 10.1016/j.jdiacomp.2022.108226 [doi]
AB  - AIMS: The aim of this prospective study was to examine the relationship between 
      controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) 
      with the risk of developing a composite endpoint inclusive of incident acute 
      myocardial infarction (AMI), cerebrovascular insult (CVI) or chronic kidney 
      disease (CKD) in people with type 2 diabetes mellitus (T2DM). METHODS: This study 
      included 238 T2DM outpatients without chronic liver diseases. RESULTS: The 
      patient population was followed for a median period of 7.6 years. Kaplan-Meier 
      survival analyses showed that there was a higher proportion of patients who 
      developed the aforementioned composite outcome (P < 0.001 by the log-rank test), 
      as well as CKD (P < 0.001) or AMI alone (P = 0.014) among those with elevated CAP 
      values (>/=238 dB/m) at baseline. Similarly, Kaplan-Meier survival analyses showed 
      that there was a higher proportion of patients who developed the composite 
      outcome (P < 0.001), as well as CKD (P < 0.001), or AMI alone (P < 0.001) among 
      those with elevated LSM values (>/=7.0/6.2 kPa). In multivariable regression 
      analyses, the presence of elevated CAP (adjusted-hazard ratio 2.34, 95% CI 
      1.32-4.15) and elevated LSM (adjusted-hazard ratio 2.84, 95% CI 1.92-4.21), 
      independently of each other, were associated with a higher risk of developing the 
      composite outcome, as well as incident AMI or CKD alone after adjusting for 
      traditional cardiovascular risk factors and diabetes-related variables. 
      CONCLUSIONS: Our study shows that the elastographic parameters of liver steatosis 
      and fibrosis independently predict the long-term risk of developing chronic 
      vascular complications in T2DM patients.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Mikolasevic, I
AU  - Mikolasevic I
AD  - Department of Gastroenterology, University Hospital Center Rijeka, Rijeka, 
      Croatia; Faculty of Medicine, Rijeka, Croatia. Electronic address: 
      ivana.mikolasevic@gmail.com.
FAU - Domislovic, V
AU  - Domislovic V
AD  - Department for Gastroenterology and Hepatology, University Hospital Center 
      Zagreb, Zagreb, Croatia.
FAU - Ruzic, A
AU  - Ruzic A
AD  - Faculty of Medicine, Rijeka, Croatia; Clinic for Cardiology, University Hospital 
      Center Rijeka, Rijeka, Croatia.
FAU - Hauser, G
AU  - Hauser G
AD  - Department of Gastroenterology, University Hospital Center Rijeka, Rijeka, 
      Croatia; Faculty of Medicine, Rijeka, Croatia; Faculty of Health Studies, Rijeka, 
      Croatia.
FAU - Rahelic, D
AU  - Rahelic D
AD  - Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, 
      Merkur University Hospital, Zagreb, Croatia; University of Zagreb Faculty of 
      Medicine, Zagreb, Croatia; University of Osijek Faculty of Medicine, Osijek, 
      Croatia.
FAU - Klobucar-Majanovic, S
AU  - Klobucar-Majanovic S
AD  - Faculty of Medicine, Rijeka, Croatia; Department for Diabetes, Endocrinology and 
      Metabolic Diseases, UHC Rijeka, Croatia.
FAU - Krznaric, Z
AU  - Krznaric Z
AD  - Department for Gastroenterology and Hepatology, University Hospital Center 
      Zagreb, Zagreb, Croatia; University of Zagreb Faculty of Medicine, Zagreb, 
      Croatia.
FAU - Dobrila-Dintinjana, R
AU  - Dobrila-Dintinjana R
AD  - Faculty of Medicine, Rijeka, Croatia; Department of Oncology, UHC Rijeka, 
      Croatia.
FAU - Grgurevic, I
AU  - Grgurevic I
AD  - University of Zagreb Faculty of Medicine, Zagreb, Croatia; Department of 
      Gastroenterology, Hepatology and Clinical Nutrition, University Hospital Dubrava, 
      Zagreb, Croatia.
FAU - Skenderevic, N
AU  - Skenderevic N
AD  - Department of Gastroenterology, University Hospital Center Rijeka, Rijeka, 
      Croatia.
FAU - Lukic, A
AU  - Lukic A
AD  - Department of Gastroenterology, University Hospital Center Rijeka, Rijeka, 
      Croatia.
FAU - Targher, G
AU  - Targher G
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University of Verona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220602
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/pathology
MH  - *Elasticity Imaging Techniques
MH  - Humans
MH  - Liver/diagnostic imaging
MH  - Liver Cirrhosis/complications/diagnostic imaging/epidemiology
MH  - *Myocardial Infarction/complications/diagnostic imaging/epidemiology
MH  - *Non-alcoholic Fatty Liver Disease/complications
MH  - Prospective Studies
MH  - *Renal Insufficiency, Chronic/complications/epidemiology/pathology
OTO - NOTNLM
OT  - Controlled attenuation parameter
OT  - Diabetic complications
OT  - Liver stiffness measurement
OT  - Nonalcoholic fatty liver disease
OT  - Prospective
OT  - Type 2 diabetes
EDAT- 2022/07/09 06:00
MHDA- 2022/08/10 06:00
CRDT- 2022/07/08 22:05
PHST- 2021/11/09 00:00 [received]
PHST- 2022/05/11 00:00 [revised]
PHST- 2022/05/30 00:00 [accepted]
PHST- 2022/07/09 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/07/08 22:05 [entrez]
AID - S1056-8727(22)00132-5 [pii]
AID - 10.1016/j.jdiacomp.2022.108226 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2022 Aug;36(8):108226. doi: 
      10.1016/j.jdiacomp.2022.108226. Epub 2022 Jun 2.