PMID- 35805099
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20220725
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 13
DP  - 2022 Jun 24
TI  - T-Lymphocyte Interactions with the Neurovascular Unit: Implications in 
      Intracerebral Hemorrhage.
LID - 10.3390/cells11132011 [doi]
LID - 2011
AB  - In the pathophysiology of hemorrhagic stroke, the perturbation of the 
      neurovascular unit (NVU), a functional group of the microvascular and brain 
      intrinsic cellular components, is implicated in the progression of secondary 
      injury and partially informs the ultimate patient outcome. Given the broad NVU 
      functions in maintaining healthy brain homeostasis through its maintenance of 
      nutrients and energy substrates, partitioning central and peripheral immune 
      components, and expulsion of protein and metabolic waste, intracerebral 
      hemorrhage (ICH)-induced dysregulation of the NVU directly contributes to 
      numerous destructive processes in the post-stroke sequelae. In ICH, the damaged 
      NVU precipitates the emergence and evolution of perihematomal edema as well as 
      the breakdown of the blood-brain barrier structural coherence and function, which 
      are critical facets during secondary ICH injury. As a gateway to the central 
      nervous system, the NVU is among the first components to interact with the 
      peripheral immune cells mobilized toward the injured brain. The release of 
      signaling molecules and direct cellular contact between NVU cells and 
      infiltrating leukocytes is a factor in the dysregulation of NVU functions and 
      further adds to the acute neuroinflammatory environment of the ICH brain. Thus, 
      the interactions between the NVU and immune cells, and their reverberating 
      consequences, are an area of increasing research interest for understanding the 
      complex pathophysiology of post-stroke injury. This review focuses on the 
      interactions of T-lymphocytes, a major cell of the adaptive immunity with 
      expansive effector function, with the NVU in the context of ICH. In cataloging 
      the relevant clinical and experimental studies highlighting the synergistic 
      actions of T-lymphocytes and the NVU in ICH injury, this review aimed to feature 
      emergent knowledge of T cells in the hemorrhagic brain and their diverse 
      involvement with the neurovascular unit in this disease.
FAU - Shi, Samuel X
AU  - Shi SX
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Vodovoz, Samuel J
AU  - Vodovoz SJ
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Xiu, Yuwen
AU  - Xiu Y
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Liu, Ning
AU  - Liu N
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Jiang, Yinghua
AU  - Jiang Y
AUID- ORCID: 0000-0002-7344-7028
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Katakam, Prasad V G
AU  - Katakam PVG
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Bix, Gregory
AU  - Bix G
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Dumont, Aaron S
AU  - Dumont AS
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
FAU - Wang, Xiaoying
AU  - Wang X
AUID- ORCID: 0000-0003-3636-7931
AD  - Clinical Neuroscience Research Center, Department of Neurosurgery & Neurology, 
      Tulane University School of Medicine, New Orleans, LA 70112, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220624
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Blood-Brain Barrier/metabolism
MH  - Brain/metabolism
MH  - Cerebral Hemorrhage/metabolism
MH  - Humans
MH  - *Stroke/metabolism
MH  - *T-Lymphocytes/metabolism
PMC - PMC9266108
OTO - NOTNLM
OT  - T cells
OT  - immunology
OT  - intracerebral hemorrhage
OT  - neurovascular unit
OT  - stroke
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/10 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/06/24
CRDT- 2022/07/09 01:05
PHST- 2022/04/25 00:00 [received]
PHST- 2022/06/15 00:00 [revised]
PHST- 2022/06/22 00:00 [accepted]
PHST- 2022/07/09 01:05 [entrez]
PHST- 2022/07/10 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/06/24 00:00 [pmc-release]
AID - cells11132011 [pii]
AID - cells-11-02011 [pii]
AID - 10.3390/cells11132011 [doi]
PST - epublish
SO  - Cells. 2022 Jun 24;11(13):2011. doi: 10.3390/cells11132011.